Genetic Risk Estimation and Improving Health Disparities in Breast Cancer Screening of Racial Minorities

Overview

About this study

The aim of this study is to use the combine clinical risk assessment models that are already used in routine clinical practice with information derived from polygenic risk score (PRS) testing in women of racial minorities to see if this can improve adherence to recommended breast cancer screening and prevention strategies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Women who identify as Black or Hispanic.
  • Women > 30 years old and < 75 years old.
  • Women with any of the following:
    • IBIS (Tyrer-Cuzick) score for the lifetime risk ≥ 20%;
    • History of biopsy proven atypical ductal hyperplasia or atypical lobular hyperplasia;
    • History of biopsy proven lobular carcinoma in situ.
  • Able to participate in all aspects of the study.
  • Understand and signed the study informed consent.

Exclusion Criteria:

  • Women whose lifetime risk for breast cancer falls below the threshold (< 20 % lifetime risk).
  • Unable to give informed consent.
  • Prior history of invasive breast cancer, ductal carcinoma in situ or other breast cancers.
  • At high risk due to prior radiation therapy to the chest.
  • Women who are pregnant or breastfeeding.
  • Prior risk reducing or prophylactic mastectomy.

Eligibility last updated 4/7/22. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Sabrina Sahni, M.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available
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CLS-20540914

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