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Acute Exercise on Exosome Associated Biomarkers

Overview

About this study

The purpose of this study is to determine the content of exosomes in plasma released following one session of acute exercise. This study will apply novel methodologies developed in our laboratory to identify molecules such as proteins and miRNAs that may be therapeutically useful in treating type 2 diabetes, obesity, and age-related disorders. 

 

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Individuals age 18 to 45 years.

Exclusion Criteria:

  • Individuals less than 18 or more than 45 years of age.
  • BMI > 32 kg/m^2. 
  • Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease.
  • Orthopedic problems that would keep them from being able to perform an exercise.
  • Medications that are known to impact mitochondrial function: 
    • Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta-blockers, sulfonylureas, insulin, In, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist). 
  • Smoking.
  • Pregnancy. 

Eligibility last updated 2/21/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

K Nair, M.D., Ph.D.

Closed for enrollment

Contact information:

Frederick de Ruiter

(507) 255-8932

DeRuiter.Frederick@mayo.edu

More information

Publications

Publications are currently not available

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