Transcatheter Pulmonary Valve Replacement and Catheter Ablation of Ventricular Tachycardia in Tetralogy of Fallot

Overview

About this study

The aim of this study is to determine the outcomes of catheter ablation before transcatheter PVR among patients with Tetralogy of Fallot (TOF, a specific type of congenital heart defect). It is hypothesized that a combination of successful catheter ablation and transcatheter PVR placement will result in a reduction in a conventional risk score calculation (and consequently, fewer patients meeting criteria for primary prevention ICD placement) owing to a combination of VT circuit elimination and favorable RV remodeling.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients with TOF or TOF-related variants.
Age ≥ 18 years.
Planned transcatheter valve placement in native RVOT.

Exclusion Criteria:

Individuals < 18 years.
Non-TOF related variants (i.e., pulmonary stenosis, PA-IVS, etc.).
Prior catheter or surgical ablation of ventricular tachycardia (VT).

Eligibility last updated 1/24/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Jacksonville, Fla. Mayo Clinic principal investigator Christopher McLeod, M.B., Ch.B., Ph.D.	Open for enrollment	Contact information: Thomas Ladas M.D., Ph.D. Ladas.Thomas@mayo.edu
Rochester, Minn. Mayo Clinic principal investigator Christopher McLeod, M.B., Ch.B., Ph.D.	Open for enrollment	Contact information: Erika Douglass M.P.H. (904) 953-6595 Douglass.Erika@mayo.edu

Mayo Clinic Location

Status

Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Christopher McLeod, M.B., Ch.B., Ph.D.

Open for enrollment

Contact information:

Thomas Ladas M.D., Ph.D.

Ladas.Thomas@mayo.edu

Rochester, Minn.

Mayo Clinic principal investigator

Christopher McLeod, M.B., Ch.B., Ph.D.

Open for enrollment

Contact information:

Erika Douglass M.P.H.

(904) 953-6595

Douglass.Erika@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials