Clinical Trials

Inclusion Criteria:

- Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.

- Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass.
Complex cardiac surgery will be defined as surgery involving more than one heart
valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass
graft procedures (aortic repair not excluded if meets other criteria).

Exclusion Criteria:

- Left or right ventricular assist device implantation or explantation.

- Procedures not requiring cardiopulmonary bypass.

- Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy
(treated endocarditis is not excluded).

- Severe hepatic disease resulting in ascites.

- Pre-operative significant renal dysfunction including a baseline creatinine equal to
or greater than 2 mg/dL or requiring dialysis.

- Immunosuppressive medication use (including current IV or oral steroids use, use of
anti-rejection medications for transplant within 1 month, or chemotherapy within 6
months).

- Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 2/15/23. Questions regarding updates should be directed to the study team contact.