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A Study to Assess Post-Intensive Care Syndrome – Pediatrics

Overview

About this study

The purposes of this study are to to determine the physical, cognitive, emotional, and social health outcomes and trajectory of recovery in a population of children post-critical illness, to determine the baseline health, presenting problem, and PICU factors associated with impaired physical, cognitive, emotional, and social outcomes among PICU survivors, and to determine the emotional and social health outcomes in parents and siblings of PICU survivors. Our primary goal is to explicate the impact of pediatric critical illness over a two-year period of time to guide future intervention research to optimize child and family outcomes. Our overall goal is to improve the health and well-being of PICU survivors and their families.

Pediatric Intensive Care Unit (PICU) survival has increased substantially over the past three decades, rendering mortality alone an insufficient metric for pediatric critical illness outcomes assessment. Currently, a comprehensive understanding of PICU morbidity and the trajectory of recovery among PICU survivors and their families is limited. Post-intensive care syndrome (PICS) consists of new or worsening impairments in physical, cognitive, or mental health status that arise and may persist after critical illness. The characteristics of PICS in children (PICS-p) are unknown. At this time, we cannot identify modifiable risk factors for poor PICU outcomes and/or develop systematic, timely, and targeted PICU or post-PICU interventions to improve PICU morbidity without first understanding the recovery in children who commonly share the PICU experience.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Current admission is the child’s first PICU admission.
  • Patient age ≥ 4 weeks and ≥ 44 weeks corrected gestational age, and < 16 years (has not yet reached 16th birthday) on PICU admission.
  • At least one parent/legal guardian (≥ 18 years of age or considered emancipated) living with the potential subject.
  • PICU LOS of ≥ 3 days (covering at least 3 nights from midnight to 7am) in which the patient received intensive care therapies for organ dysfunction (invasive mechanical ventilation, vasopressors/inotropes, acute renal replacement therapy, or other extracorporeal therapies).
  • Anticipated patient discharge to home (direct or indirect).

 Exclusion Criteria:

  • Patient history of neonatal intensive care unit hospitalization.
  • Life expectancy not anticipated to be more than one year (e.g., active do not resuscitate [DNR] plan or actively managed by the palliative care team for end-of-life symptom management).
  • Patient in foster care or ward of the state.

Eligibility last updated 10/18/21. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sheri Crow, M.D.

Open for enrollment

Contact information:

Katrina Pierce CCRP

(507) 266-1078

Pierce.Katrina@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20527461

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