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Quantitative Assessment of Skin and Liver of Patients with Diffuse Systemic Sclerosis Using Shear-Wave Ultrasound Elastography

Overview

About this study

This study aims to evaluate if the skin thickness (the measurement of the dermis) or stiffness as part of the US-SWE exam as we can see it on grayscale US differs between SSc patients and controls and to evaluate if there is associated liver stiffness by US-SWE in patients with SSc as compared to controls.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years.
  • 2013 ACR/EULAR classification criteria for SSc fulfilled and all patients with dSSc.
  • We will allow enrolled patients to be on any kind of immunosuppressant medications, including but not limited to steroids, methotrexate, azathioprine, mycophenolate, rituximab, cyclophosphamide, or on the newly approved antifibrotic medication nintedanib.

Exclusion Criteria:

  • Previous or planned hematopoietic stem cell transplantation.
  • Active neoplasm of any kind.
  • Previously known liver disease, including, but not limited to alcohol-induced liver cirrhosis.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Nirvikar Dahiya, M.D.

Closed for enrollment

Contact information:

Alicia Rodriguez Pla M.D., Ph.D.

RodriguezPla.Alicia@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20521074

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