Clinical Trials

Inclusion Criteria:

• Resident of Southeastern Minnesota (Olmsted, Dodge, Fillmore, Mower, Freeborn, Wabasha, or Steele County).
• Age ≥ 75 years old.
• Current diagnosis of moderate or severe aortic stenosis by most recent (within 6 months at most) echocardiogram as defined by:
  • Moderate Aortic Stenosis (AS): 1.0 cm^2 < aortic valve area (AVA) ≤ 1.5 cm^2;
  • Severe AS: AVA ≤ 1.0 cm^2.

Exclusion Criteria:

• Any cardiac surgery or major chest trauma within 4 weeks of pyrophosphate (PYP) scan (or myocardial infarct imaging).
• Myocardial infarction within 4 weeks of PYP scan defined by typical angina, EKG changes and significant change in serial troponins.
  • Note that chronic troponin elevation is extremely common in cardiac amyloidosis.
• Prior or current exposure to Plaquenil (Hydroxychloroquine).