Clinical Trials

Inclusion Criteria:

• Admission to the hospital at any point during illness.
• ≤ 25 years of age (as of October 15, 2020 only patients < 21 years of age are eligible).
• Hospitalization is associated with SARS-CoV-2 with either:
  • SARS-CoV-2 positive test (PCR or antibody) prior to, on admission or during hospitalization; OR
  • Strong clinical suspicion (with confirmed exposure) that complications are due to COVID-19 despite negative SARS-CoV-2 test.
• (as of October 15, 2020) Symptoms or signs of disease thought to be due to COVID-19 or MIS-C OR an asymptomatic patient with BCH coordinating site approval.

Exclusion Criteria:

• Never tested for SARS-CoV-2.
• Hospitalization is associated with a non-COVID-related acute disorder that may result in significant changes in their immune response (e.g., burns, crush injury, major trauma) (exclusion criteria 3-6 added for patients enrolled October 15th, 2020 onwards).
• Nosocomial SARS-CoV-2 infection.
• Acquired immune compromise at baseline (HIV; on active chemotherapy; active cancer; on immune modulating therapy for rheumatologic, immune, or oncologic disorders or after transplantation to prevent rejection).
• Limitations on life support due to poor prognosis.
• End stage lung disease awaiting transplant or needing chronic mechanical ventilator support.