National Biological Sample and Data Repository for Pulmonary Arterial Hypertension

Overview

About this study

The specific purpose of this study is to establish a national biorepository of biological samples and genetic data of patients with the World Health Organization (WHO) Group 1 pulmonary arterial hypertension (PAH). The function of this biorepository is to collect the samples from the patients, generate the proposed genetic data, and widely promote and distribute the samples/data to the scientific community. Investigators requesting samples will submit requests and proposed uses of the samples which will be reviewed by a committee comprised of investigators from several of the enrolling centers.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

The intended participants are those meeting the criteria of the diagnosis of WHO Group 1 PAH.
- These criteria are:
  - Mean pulmonary artery pressure (PAP) >25 mm Hg at rest (30 mm Hg with exercise)
  - Pulmonary capillary wedge pressure (PCWP) ≤18 mm Hg (traditional is PWCP ≤15 mm Hg)
  - Pulmonary vascular resistance (PVR) ≥240 dynes·sec·cm-5.
- Children under the age of 18 are eligible to participate with proper assent (age 7 and greater) and parental consent.

Exclusion Criteria:

Only subjects diagnosed with WHO Group 1 PAH will be enrolled.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Jacksonville, Fla. Mayo Clinic principal investigator Charles Burger, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Charles Burger, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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