Clinical Trials

Inclusion Criteria:

Arm 1 - Screening

• Age 55-77 years old.
• Current and former smokers with 30 pack-years or more(and quit less than 15 years ago)

 Arm 2 - Incidental

• Age > 45 years old.
• Current and former smokers with 10 pack-years or more (and quit less than 15 years ago).

Exclusion Criteria:

• History or previous diagnosis of primary lung cancer, metastatic lung cancer, or any other non-lung cancer within 5 years (not including non-melanoma skin cancer).
• Any receipt of cytotoxic agents within the past 6 months.
• Symptoms of lung cancer (unexplained weight loss 10 lbs or more in 3 months, recent hemoptysis).
• Diagnosis of pure ground glass opacities for the target lesion on chest CT within the last 12 months (i.e., mixed features on the target lesion and pure ground glass opacity on non-target lesions are acceptable as mentioned above).