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Using Laser Endomicroscopy to Predict Recurrence of Barrett's Esophagus

Overview

About this study

The purpose of this study is to determine whether the use of a volumetric laser endomicroscopy (VLE) scan of a patient with Barrett's Esophagus who has been treated with endoscopic therapy and achieved CRIM can predict disease recurrence. This approach could help identify individuals at low risk of recurrence who may benefit from decreased frequency of surveillance endoscopy.  By the same token, a VLE scan could also help identify individuals at high risk of recurrence who may benefit from earlier therapeutic intervention.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient over the age of 18.
  • Patient undergoing an upper endoscopy with prior biopsy confirmed Barrett’s Esophagus.
  • Ability to provide written, informed consent.
  • No significant esophagitis (LA grade

Exclusion Criteria:

  • Patients for whom use of the NvisionVLE device would be in conflict with the instruction for use.
  • Prior esophageal or gastric surgical resection.
  • Significant esophageal stricture requiring dilatation.
  • Patients who require anticoagulation for who biopsy would be contraindicated.
  • Patients who are known to be pregnant.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Cadman Leggett, M.D.

Closed for enrollment

Contact information:

Bryan Linn

(507)255-4631

Linn.Bryan@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20462692

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