Clinical Trials

Inclusion Criteria

1. Do not meet symptom-based criteria for constipation, fecal incontinence or irritable bowel syndrome by validated questionnaires
2. Able to provide written informed consent before participating in the study
3. Able to communicate adequately with the investigator and to comply with the requirements for the entire study.

Exclusion Criteria

1. BMI ≥ 30 kg/m²
2. Clinical evidence of significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric or other disease that may interfere with the objectives of the study and/or pose safety concerns.
3. During digital rectal examination, markedly reduced anal contractile response or perineal descent during simulated evacuation.
4. Medications that may alter gastrointestinal motility, e.g., serotoninergic agents, alpha adrenergic agonists or antagonists, calcium channel blockers or opiates.
5. Prior pelvic radiation; history of or current inflammatory bowel disease
6. Putative risk factors for pelvic floor trauma, i.e. > 4 vaginal deliveries, known birthweight >4500 gms (Macrosomia), known 4th degree perineal tear, or known forceps use.
7. Any anorectal procedures (including for hemorrhoids)