Diagnostic and Prognostic Validity of Tissue-based Biomarker Assay for Acute Graft-versus-host Disease of the Skin: A Retrospective Study

Overview

About this study

The purpose of this study is to validate the diagnostic and prognostic utility of our tissue-based assay, the aim is to perform a multi-institution, retrospective study of our assay compared with the current clinical gold standard (clinicopathologic correlation and prospective observation of clinical course, respectively).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Adults who have undergone hematopoietic cell transplantation, with skin biopsies showing acute graft-versus-host disease (GVHD) or non-GVHD mimicking rash
Patients with specimens with sufficient tissue remaining in the tissue block
Patients for whom ≥3 months follow-up information (or date of expiration, if within 3 months of biopsy) is available in the medical record

Exclusion Criteria:

Patients who decline to be involved in retrospective research
Lack of inclusion criteria

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Julia Lehman, M.D.	Closed for enrollment	Contact information: Aaron Mangold M.D. (480)301-5686 Mangold.Aaron@mayo.edu
Rochester, Minn. Mayo Clinic principal investigator Julia Lehman, M.D.	Closed for enrollment	Contact information: Julia Lehman M.D. (507)284-2555 Lehman.Julia@mayo.edu
Jacksonville, Fla. Mayo Clinic principal investigator Julia Lehman, M.D.	Closed-enrolling by invitation What is this? (?) "Close" Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.	Contact information: Mark Cappel M.D. (904)953-7214 Cappel.Mark@mayo.edu

Mayo Clinic Location

Status

Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Julia Lehman, M.D.

Closed for enrollment

Contact information:

Aaron Mangold M.D.

(480)301-5686

Mangold.Aaron@mayo.edu

Rochester, Minn.

Mayo Clinic principal investigator

Julia Lehman, M.D.

Closed for enrollment

Contact information:

Julia Lehman M.D.

(507)284-2555

Lehman.Julia@mayo.edu

Jacksonville, Fla.

Mayo Clinic principal investigator

Julia Lehman, M.D.

Closed-enrolling by invitation

Contact information:

Mark Cappel M.D.

(904)953-7214

Cappel.Mark@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials