Exercise Intervention - and Impact on Hospitalization

Overview

About this study

Skeletal muscle abnormalities (sarcopenia) and frailty are common complications seen in patients with end-stage liver disease. The presence of these complications portends poor prognosis. The purpose of this study is to assess the impact of a formal home based video strengthening program (REST) on sarcopenia and frailty. We also want to assess the impact of this exercise program on complication rates, hospitalization, on quality of life (QOL) and on survival.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Waitlisted for liver transplant with poor 6MWT

Exclusion Criteria:

Age < 18 years
Recent hospitalization (within 14 days) due to decompensation
Variceal bleeding in the previous 1 month
Large esophageal varices without primary prophylaxis
Active excessive alcohol intake (in the previous 3 months)
Current overt uncontrolled hepatic encephalopathy
Hepatopulmonary syndrome with uncontrolled hypoxia
Portopulmonary hypertension
Inability to perform exercise
Marked symptomatic comorbidities (cardiac, pulmonary, renal)
Multiorgan transplant

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Jacksonville, Fla. Mayo Clinic principal investigator Liu Yang, M.B.B.S.	Closed for enrollment
Rochester, Minn. Mayo Clinic principal investigator Kymberly Watt, M.D.	Closed for enrollment
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Elizabeth Carey, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Liu Yang, M.B.B.S.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

Kymberly Watt, M.D.

Closed for enrollment

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Elizabeth Carey, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials