Exercise Preconditioning and Breast Cancer Cardiotoxicity

Overview

About this study

The purpose of this study is to determine whether a supervised exercise-training program, initiated prior to chemotherapy induction (pre-conditioning) and continued throughout chemotherapy treatment, can preserve short- and long-term cardiovascular performance, skeletal muscle function, cognitive ability and quality of life better than current standard or care recommendations for exercise during chemotherapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent
Subjects will have been recently diagnosed with breast cancer (stage I, II or III)
Subjects must be scheduled by their oncologist to undergo anthracycline based chemotherapy (doxorubicin and cyclophosphamide) in the neoadjuvant/adjuvant setting

Exclusion Criteria:

Unstable angina
Myocardial infarction in the past 4 weeks
Uncompensated heart failure
New York Heart Association class IV symptoms
Complex ventricular arrhythmias
Medical orthopedic conditions precluding stationary cycling
Medical conditions precluding neuropsychological assessment
Symptomatic severe aortic stenosis
Acute pulmonary embolus
Acute myocarditis
Untreated high-risk proliferative retinopathy
Recent retinal hemorrhage
Uncontrolled hypertension
Sodium and/or Potassium ≥ Grade 2
Pregnant Women

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Farouk Mookadam, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Farouk Mookadam, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials