A Study to Evaluate the Effect of Hyperoxia on Glucose Metabolism in Type 2 Diabetics

Overview

About this study

The purpose of this study is to evaluate if breathing pure oxygen overnight affects insulin sensitivity in participants with diabetes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

T2DM and
On Metformin monotherapy and able to be washed off for 8 weeks
HbA1c 6.5% -9.5%
FPG ≥126 mg/dL (7.0 mmol/L) <270 mg/dl at screening
25 to 60 years of age
BMI 22-37 kg/m²

Exclusion Criteria

Diabetic meds other than metformin for 3months prior to study
Hepatobiliary or renal disease
Respiratory disease that may compromise the study in the opinion of the investigator
Concurrent illness or chronic disease that in the opinion of the investigator may affect the outcome of the study
Severe sleep apnea (sleep apnea will be analysed as a covariate)
On antihypertensive medication
Pregnant or lactating females
Fasting triglycerides >500mg
Nasal congestion/obstruction as determined by PI

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Adrian Vella, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials