Clinical and Imaging Factors Associated with Symptoms in Patients with Severe Aortic Stenosis

Overview

About this study

The aim of this study is to reveal differences between symptomatic and asymptomatic severe AS patients matched for anatomic (aortic valve area) and hemodynamic (mean gradient) AS severity. The secondary aim is to evaluate functional and prognostic significance of strain value of LV and RV.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Severe AS and normal left ventricular ejection fraction (>50%)
Severe AS is defined as mean gradient >40 mm Hg and aortic valve area (AVA) ≤ 1.0 cm2 by 2-dimensional (2-D) and Doppler echocardiography.

Exclusion Criteria:

Age less than 18years
Poor echocardiographic images/ difficult to analysis
Prior percutaneous aortic balloon valvuloplasty, or prior valve replacement or cardiac surgery
Acute coronary syndrome at baseline
Infective endocarditis at baseline
Patient who is not able to provide reliable descriptions of their symptoms due to dementia
Subvalvular left ventricular outflow obstruction
End-stage renal disease on chronic dialysis
Patient who denies access to his/her record for research

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Jae Oh, M.D.	Closed for enrollment	Contact information: Jae Oh M.D. oh.jae@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Jae Oh, M.D.

Closed for enrollment

Contact information:

Jae Oh M.D.

oh.jae@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials