Doppler Analysis of Patent Foramen Ovale

Overview

About this study

AIMS:

1. Determine the feasibility of measuring velocity of flow across a patent foramen ovale and using this Doppler spectrum to estimate left atrial pressures.

2. Correlate PFO velocity Doppler profile with the degree of diastolic dysfunction.

3. To Correlated PFO velocity and Doppler derived left atrial pressure with left atrial pressure measured during cardiac catheterization in a subset of (n=20) subjects for validation of this methodology.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

All patients > 18 years old and clinically stable patients presenting to the Mayo Echocardiography Laboratory for comprehensive transthoracic echocardiogram.
In those patients found to have a PFO on screening examination, further interrogation of the PFO with continuous wave Doppler will be performed.
This should not involve any further physical maneuvers for the patient and should not delay study time in the clinical study pods.

Exclusion criteria:

Difficult echocardiographic 2D images.
Patients presenting specifically for limited transthoracic echocardiograms where obtaining subcostal images and performing Doppler interrogation of possible PFO will cause undue delay
More than moderate mitral valve disease
Frequent ectopic beats

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Jae Oh, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Jae Oh, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials