Clinical Trials

Inclusion Criteria:

1. ≥ 40 years of age
2. Diagnosed with idiopathic pulmonary fibrosis (IPF) by enrolling investigator
3. Signed informed consent

Exclusion Criteria:

1. Received antimicrobial therapy in the past 30 days
2. Contraindicated for antibiotic therapy, including but not exclusive to:
   1. Allergy or intolerance to both tetracyclines AND trimethoprim, sulfonamides or their combination
   2. Allergy or intolerance to tetracyclines AND known potassium level > 5 mEq/L in the past 90 days.
      • If the enrolling physician feels the potassium level has normalized, documentation to that effect must be provided.
   3. Allergy or intolerance to tetracyclines AND concomitant use of angiotensin-converting enzyme (ACEI), angiotensin II receptor blockers (ARB), or potassium sparing diuretic
   4. Allergy or intolerance to tetracyclines AND known glucose-6-phosphate dehydrogenase deficiency
   5. Allergy or intolerance to tetracyclines AND untreated folate or B12 deficiency
   6. Allergy or intolerance to tetracyclines AND known renal insufficiency (defined as a glomerular filtration rate (GFR) < 30 ml/min within the previous 90 days)
      • If the enrolling physician feels the renal dysfunction has resolved, documentation to that effect must be provided.
3. Pregnant or anticipate becoming pregnant
4. Use of an investigational study agent for IPF therapy within the past 30 days.
5. Concomitant immunosuppression with azathioprine, mycophenolate, cyclophosphamide, or cyclosporine.