Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload

Overview

About this study

The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age ≥ 18 years < 90 years.
Patients identified with decompensated heart failure (DHF) and diagnosed clinically with volume overloaded by the primary admitting provider or ED evaluation.
New York Heart Association functional Class III-IV status/Stage C-D HF.
ischemic or non-ischemic etiology of HF.
LVEF < 70% measured within 6 months of study data collection.

Exclusion Criteria:

Known significant intrinsic chronic kidney disease (baseline GFR < 15 ml/min/1.73m²) patients.
Receiving hemodialysis.
Known renal artery stenosis disease.
Females who are pregnant or of childbearing potential.

Eligibility last updated 5/25/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Vuyisile Nkomo, M.D., M.P.H.	Open for enrollment	Contact information: Wayne Miller M.D., Ph.D. (507) 284-8846 miller.wayne@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Vuyisile Nkomo, M.D., M.P.H.

Open for enrollment

Contact information:

Wayne Miller M.D., Ph.D.

(507) 284-8846

miller.wayne@mayo.edu

More information

Publications

Publications are currently not available

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