Risk Factors for Exfoliation Syndrome, Exfoliation Glaucoma and Primary Open Angle Glaucoma

Overview

About this study

We are doing this research study to find out the genetic and environmental factors that contribute to glaucoma (high pressure in the eye), which can cause vision loss and blindness if untreated. Exfoliation syndrome is a common condition that can lead to exfoliation glaucoma. The most common form of glaucoma is called primary open angle glaucoma. Identifying the factors that lead to exfoliation syndrome and glaucoma may help us to develop future tests and treatments for these conditions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: Cases

Exfoliation Syndrome
Exfoliation Glaucoma
Angle Closure Glaucoma
Primary Open Angle Glaucoma

Exclusion Criteria: Cases

None for exfoliation status but glaucoma not mentioned above will be scored as unknown
Individuals who have received chronic steroid therapy

Controls:

Individuals will be scored as unaffected if the following criteria are met:

absence of exfoliation material either at clinical exam or in clinical records,
IOP without treatment less than 22 mmHg, and
No evidence of glaucomatous optic nerve disease (symmetric vertical cup to disc ratio of less than 0.6), and
age >60 as ES is strongly age-related.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Arthur Sit, M.D., M.S.	Closed for enrollment	Contact information: Elainey Hardtke (507) 538-4122 Wada.Elainey@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D., M.S.

Closed for enrollment

Contact information:

Elainey Hardtke

(507) 538-4122

Wada.Elainey@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials