The Role of Bile Acid Diarrhea in Adolescents with Irritable Bowel Syndrome

Overview

About this study

The purpose of this study is to measure 48 hour fecal bile acids in IBS-D adolescents and compare it to HC; measure serum C4 and FGF-19 in adolescents with IBS-D and HC and compare it to 48 hour fecal bile acid loss; measure primary bile acids concentration in 48 hour stool collection in adolescents with IBS-D and compare it to HC.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Adolescents with IBS-D

Age: 8-17 years
Gender: male or female
IBS-D diagnosis according to ROME IV criteria using Abridged bowel symptom questionnaire (16) and validated stool diary card (attached in appendix)
No other underlying cause to account for gastrointestinal symptoms

Healthy adolescents with no gastrointestinal symptoms

Age: 8-17 years
Gender: male or female
No known gastrointestinal disease

Exclusion Criteria:

Adolescents with IBS-D

Previous abdominal surgery
Systemic antibiotic use within 3 months of collection

Healthy adolescents with no gastrointestinal symptoms

Patients with previous abdominal surgeries
Gastrointestinal symptoms suggestive of functional gastrointestinal disorders
Systemic antibiotic use within 3 months of collection

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Mhd Louai Manini, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Mhd Louai Manini, M.D.

Closed for enrollment

More information

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