Echocardiographic Measures of Pulmonary Vascular Distensibility and Effects on Lung Diffusing Capacity

Overview

About this study

The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Group 1: 12 young (18-34y) healthy individuals; males and females Group 2: 12 old (>65y) healthy individuals; males and females

Inclusion Criteria:

No history of cardiac, pulmonary, or metabolic disorders
Body Mass Index (BMI) < 30
Normal pulmonary function (>80% predicted)
Non-smoker
Blood pressure <150/90
Adequate TR jet during echocardiographic screening

Exclusion Criteria:

Women who are pregnant
History of cardiac, pulmonary, or metabolic disorders
Body Mass Index (BMI) > 30
Lower than normal pulmonary function (<80% predicted)
History of smoking
Blood pressure >150/90
Inadequate TR jet during echocardiographic screening
Medications: Nitrates

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Bruce Johnson, Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

More information

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