Clinical Trials

Inclusion Criteria:

• Adult (≥18 years of age) donors recruited for lymphoid tissue biopsy by the principal investigator, co-investigators, study coordinators, Infectious Disease clinic nurses, or clinic phlebotomists.
• Required to have a platelet count >50,000/mm³ documented in the medical record within 30 days prior to the procedure.
• Eligible participants may have HIV infection, or another infection or inflammatory condition that may affect the content or structure of lymph nodes, or no known disease if used as a normal control. 

Exclusion Criteria:

• Inability to provide informed consent
• Self-reported or clinically documented pregnancy
• Known allergy to local anesthetic
• Significant bleeding diatheses
• Active bacterial infection
• Any other condition that in the opinion of the principal investigator would increase the risk of the adverse events associated with the surgical procedure.