The Influence of Pedal Rate on Activation of Locomotor Afferents and Cardiovascular Responses

Overview

About this study

The first purpose is to determine the influence of pedal rate during constant-load submaximal locomotor exercise on ventilation, gas exchange, blood pressure, and cardiac hemodynamic responses during post-exercise activation of group III and IV locomotor muscle afferents using a novel application and integration of two separate but related scientific questions to better understand peripheral mechanisms of exercise tolerance in humans. The second purpose is to compare ventilation, gas exchange, blood pressure, and cardiac hemodynamic responses across the adult healthy aging spectrum.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy adults (≥18 years of age)
Nno history of cardiovascular, pulmonary, metabolic, neurologic, orthopaedic, or other diseases affecting the neuromuscular system
BMI ≤35 kg/m2
Current non-smokers with smoking history <15 pack years
Able to engage in exercise (i.e., without orthopedic limitations or musculoskeletal disorders)

Exclusion Criteria:

History of cardiovascular, pulmonary, metabolic, neurologic, orthopaedic, or other diseases affecting the neuromuscular system
BMI >35 kg/m2
current smokers with smoking history ≥15 pack years
Not able to engage in exercise (e.g., known orthopedic limitations or musculoskeletal disorders)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Thomas Olson, M.S., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Olson, M.S., Ph.D.

Closed for enrollment

More information

Publications

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