A Study of the Role of the Forkhead Box O3a BNIP3 Pathway in Human Cardiovascular Disease

Overview

About this study

The purpose of this study is to collect cardiac biopsies and assess the activity of the signaling pathway in patients with cardiovascular disease by using transmission electron microscopy to study mitochondrial structure and morphology and by assessing the biology of the genes and proteins of the FOXO3a effector, BNIP3.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Age 18 or older
Should have a recent echo, preferably within one to three months prior to surgery
Diabetic patients: A1C within 1-3 months of enrollment

Exclusion Criteria

Acute Coronary Syndrome (STEMI or NSTEMI) within the past 6 months
History of myocarditis or pericarditis, infiltrative or hypertrophic cardiomyopathy
Severe mitral regurgitation or congenital heart disease
Prior cardiac surgery
Any non-cardiac disease or condition that can significantly influence cardiac function
Advanced renal failure (CKD stage 4-5), chronic anemia (hematocrit < 30), bleeding diathesis
Any condition that could affect patient’s ability to provide informed consent
History of alcohol or drug abuse
Women of child-bearing potential

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Margaret Redfield, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Margaret Redfield, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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