A Study to Compare the Occurrence of Elevated Liver Enzymes Between Adult Patients Receiving Daily IV Fat Emulsions versus Only Three Times per Week

Overview

About this study

The purpose of this study is to compare the incidence and frequency of elevated liver enzymes or parenteral (IV) nutrition-associated liver disease, in adult patients who are receiving daily versus three time per week soybean based intravenus (IV) fat emulsions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Age 18 to 75 years old inclusive, at initiation of Home Parenteral Nutrition
Able to provide informed consent
Anticipated duration of HPN greater than 3 months
Not previously on HPN at Mayo Clinic or elsewhere
Agree to be managed by the Mayo HPN program
No history of alcohol addiction
No known liver disease (as determined by review of EMR)

Exclusion Criteria

Pregnant women
Failure to provide consent
On HPN for less than three months
Has previous proven addiction and dependence to alcohol and/or heavy alcohol consumption reported (during history or reported in the EMR)
Documented liver disease
Will not be managed by the Mayo Clinic HPN team
Has active infection (as determined by the clinician) at the initiation of HPN

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Ryan Hurt, M.D., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Ryan Hurt, M.D., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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