A Study to Compare Positron Emission Mammography with Contrast-Enhanced Breast MRI for Detecting Breast Cancer

Overview

About this study

The purpose of this study is to compare the detection sensitivity of positron emission mammography to contrast-enhanced breast MRI in women with a high suspicion of breast cancer.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Have recent imaging study (mammogram, tomosynthesis, MBI or ultrasound) interpreted as highly suspicious for malignancy or known biopsy-proven malignancy (BI-RADS Category 5 or 6 within 60 days prior to the MRI or Positron Emission Mammography study
Scheduled or will be scheduled for clinically indicated contrast-enhanced breast MRI examination
PEM must be performed within 5 business days, prior to or following the clinical MRI
Participant has signed the study-specific informed consent prior to registration
Age 25 or older

Exclusion Criteria

Unable to understand and sign the consent form
Pregnant or lactating
Physically unable to lie prone for ~20 minutes
Undergone bilateral mastectomy
Weight more than 300 lbs (weight limit on PEM table)
Have contraindications to the clinical MRI examination
Scheduled to undergo breast biopsy or surgery in the time period between the PEM and MRI studies

More information

Publications

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