A Study to Evaluate the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After A Hysterectomy

Overview

About this study

The purpose of this study is to learn more about the microbes (bacteria) that live in the vagina and the bladder. The investigators are doing this research study to understand the relationship between microbes (the microbiome) and the occurrence of urinary tract infection following surgical removal of the uterus and pelvic organ prolapse repair.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Postmenopausal females (defined by cessation of menses for one full year)
Planned surgical correction of pelvic organ prolapse with transvaginal hysterectomy and concomitant pelvic reconstruction for uterovaginal prolapse
Scheduled surgery date within 4 weeks of study consent
Physically able to self-collect vaginal swabs and clean-catch urine samples

Exclusion Criteria:

Women who are premenopausal, pregnant or nursing
Currently taking or have taken antibiotics in the past 2 weeks
History of recurrent urinary tract infections
History of mesh complications, including erosion/extrusion
Non-vaginal approach to hysterectomy or prolapse repair

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator John Occhino, M.D.	Closed for enrollment	Contact information: Marnie Wetzstein R.N. (507)266-4813 Wetzstein.Marnie@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Occhino, M.D.

Closed for enrollment

Contact information:

Marnie Wetzstein R.N.

(507)266-4813

Wetzstein.Marnie@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials