Study of Cisplatin-Induced Peripheral Neuropathy in Patients with Germ Cell Tumor

Overview

About this study

The purpose of this study is to investigate the incidence, characteristics of, and changes in chronic neuropathy symptoms related to cisplatin and evaluate the natural history of platinum induced peripheral neuropathy during active treatment and the first 12 months post chemotherapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

15 years of age or older at the time of informed consent
Has a confirmed pathologic and/or by tumor marker diagnosis of testicular or extragonadal germ cell cancer
Provide written informed consent and assent (if applicable)
Ability to complete questionnaire(s) in English by themselves or with assistance
Willing to provide a 10 mL blood sample for future DNA testing
Planning to receive at least 3 cycles of cisplatin (20 mg/m2/d for 5 days) based chemotherapy
Must agree to continued clinical follow-up at the study cancer center

Exclusion Criteria

Diagnosis (current or previous) of peripheral neuropathy (from diabetes or other causes)
Previous exposure to neurotoxic chemotherapy drugs including taxanes, platinum agents, vinca alkaloids, or epothilones
Salvage chemotherapy treatment or bone marrow transplant
- Salvage chemotherapy is defined as any treatment after relapse of the disease following initial chemotherapy treatment

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Brian Costello, M.D.	Closed for enrollment	Contact information: Cancer Center Clinical Trials Referral Office (855) 776-0015

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Brian Costello, M.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

Clinical Trials