A Study of an Integrated Approach to Treating Recurrent Lung Adenocarcinomas Resistant to Tyrosine Kinase Inhibitors

Overview

About this study

The purpose of this study is identify molecular changes in recurring lung cancer tumors, and to determine the most significant genes, pathways and clinical characteristics in these lung adenocarcinomas which are resistant to tyrosine kinase inhibitor.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

18 years or older
Lung adenocarcinoma tumors positive for any targetable genetic alterations
Have shown by CT/PET scan a partial or no response, progression or recurrence while on or after gene targeted therapy
Tumor is accessible for biopsy or surgery
Expected life is 6 months or longer

Exclusion Criteria

< 18 years
Lung cancer other than adenocarcinoma
Not able to communicate in English

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Jin Jen, M.D., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Jin Jen, M.D., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials