A Study Identifying Blood Serum Markers of the Immune System Affecting Different Features of Chronic Rhinosinusitis

Overview

About this study

The purpose of this study is to find out what immune system processes cause the chronic inflammation that happens with chronic rhinosinusitis (CRS) and if there are different immune system pathways involved among CRS patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Age 18 years and older.
Both males and females
Meet clinical definition of CRS
- nasal obstruction
- facial congestion
- facial pain-pressure-fullness
- decrease in sense of smell
Presence or absence of nasal polyps as evidenced by a CT scan or rhinoscopy

Exclusion criteria (history suggestive or presence of)

Cystic fibrosis
Primary ciliary dyskinesia
Primary immune deficiency disorder
Pregnant at time of clinic visit
Cigarette smoking in the last 6 months
SNOT-22 scores greater than 21 (to exclude those currently in exacerbation)
Oral corticosteroids in the past 2 weeks before visit
Intramuscular corticosteroids in the past 6 weeks before visit

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Rohit Divekar, M.B.B.S., Ph.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Rohit Divekar, M.B.B.S., Ph.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials