Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients

Overview

About this study

The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant. Researchers will examine blood, urine, and tissue samples and try to identify markers for certain conditions such as rejection, response to therapy, and scarring of the liver. Additionally, researchers would like to identify biomarkers that can detect damage to the native kidneys before blood levels of creatinine rises. By studying gene expression, researchers hope to be able to diagnose these conditions earlier and improve liver survival.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subjects undergoing primary deceased-donor or living donor liver transplantation.
Subject must be able to understand and provide informed consent.

Exclusion Criteria:

Need for combined organ transplantation
Previous solid organ and/or islet cell transplantation
Infection with HIV
Allergy to Iodine
Inability or unwillingness of a participant to comply with study protocol
Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator Adyr Moss, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Adyr Moss, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials