New Quantitive MRI Parameters in Assessing Kidneys of Autosomal Dominant Polycystic Kidney Disease

Overview

About this study

The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function.

Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria ADPKD participants

Male and female subjects between 18-30 years of age
Diagnosis of ADPKD
Glomerular Filtration Rate (GFR) of > or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
Ability to provide written, informed consent

Exclusion criteria for ADPKD participants

Clinically significant concomitant systemic disease
Subjects with Diabetes Mellitus
Urinary protein excretion
Abnormal urinalysis suggestive of concomitant glomerular disease
Subjects having contraindications to, or interference with MRI assessments
Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications

Inclusion criteria for Normal Volunteers

Male and female subjects between 18-30 years of age
Glomerular Filtration Rate (GFR) of > or = to 60 mL/min (Chronic Kidney Disease-Epidemiology Collaboration equation)
Ability to provide written, informed consent

Exclusion criteria for Normal Volunteers

Previous personal or family history of kidney disease
Clinically significant concomitant systemic disease
Subjects with Diabetes Mellitus
Urinary protein excretion
Abnormal urinalysis suggestive of concomitant glomerular disease
Subjects having contraindications to, or interference with MRI assessments
Subjects with supine blood pressure higher than 140/90 mm Hg or taking blood pressure medications

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Sudhakar Venkatesh, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Sudhakar Venkatesh, M.D.

Closed for enrollment

More information

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