Publications

1. Gicobi JK, Mao Z, DeFranco G, Hirdler JB, Li Y, Vianzon VV, Dellacecca ER, Hsu MA, Barham W, Yan Y, Mansfield AS, Lin Y, Wu X, Hitosugi T, Owen D, Grams MP, Orme JJ, Lucien F, Zeng H, Park SS, Dong H. Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8(+) T cells via ME1 up-regulation. Sci Adv. 2023 Nov 17; 9 (46):eadi2414 Epub 2023 Nov 15
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2. Munroe ME, Blankenship D, DeFreese D, Purushothaman M, DeJager W, Macwana S, Guthridge JM, Kamp S, Redinger N, Aberle T, Chakravarty EF, Arriens C, Li Y, Zeng H, McCarthy-Fruin KA, Osei-Onomahm SA, Thanarajasingam U, James JA, Jupe E. A Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2023 May; 75 (5):723-735 Epub 2023 Mar 06
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3. Cunningham KY, Hur B, Gupta VK, Arment CA, Wright KA, Mason TG, Peterson LS, Bekele DI, Schaffer DE, Bailey ML, Delger KE, Crowson CS, Myasoedova E, Zeng H, Rodriguez M, Weyand CM, Davis JM 3rd, Sung J. Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity. Sci Rep. 2023 Apr 1; 13 (1):5360 Epub 2023 Apr 01
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4. Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball LE, Maynard JC, Burlingame AL, Zeng H, Mansky KC, Ruan HB. O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors. Elife. 2023 Mar 2; 12 Epub 2023 Mar 02
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5. Zhou X, Qi H, Li M, Li Y, Zhu X, Amin S, Alexander M, Diadhiou C, Davidson A, Zeng H. mTORC2 contributes to systemic autoimmunity. Immunology. 2023 Mar; 168 (3):554-568 Epub 2022 Nov 02
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6. Zhou X, Zhu X, Zeng H. Fatty acid metabolism in adaptive immunity. FEBS J. 2023 Feb; 290 (3):584-599 Epub 2021 Dec 04
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7. Barham W, Hsu M, Liu X, Harrington SM, Hirdler JB, Gicobi JK, Zhu X, Zeng H, Pavelko KD, Yan Y, Mansfield AS, Dong H. A Novel Humanized PD-1/PD-L1 Mouse Model Permits Direct Comparison of Antitumor Immunity Generated by Food and Drug Administration-Approved PD-1 and PD-L1 Inhibitors. Immunohorizons. 2023 Jan 1; 7 (1):125-139
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8. An Z, Figueroa-Parra G, Zhou X, Li Y, Jaquith J, McCarthy-Fruin K, Sletten J, Warrington KJ, Weyand C, Crowson CS, Chumsri S, Knutson KL, Sanchez-Rodriguez A, Thanarajasingam U, Duarte-Garcia A, Zeng H. Immune responses and disease biomarker long-term changes following COVID-19 mRNA vaccination in a cohort of rheumatic disease patients. Front Immunol. 2023; 14:1224702 Epub 2023 July 31
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9. Tang J, Yang L, Guan F, Miller H, Camara NOS, James LK, Benlagha K, Kubo M, Heegaard S, Lee P, Lei J, Zeng H, He C, Zhai Z, Liu C. The role of Raptor in lymphocytes differentiation and function. Front Immunol. 2023; 14:1146628 Epub 2023 May 22
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10. Marty PK, Van Keulen VP, Erskine CL, Shah M, Hummel A, Stachowitz M, Fatis S, Granger D, Block MS, Duarte-Garcia A, Warrington KJ, Theel ES, Zhou X, Zeng H, Specks U, Escalante P, Peikert T. Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting Therapy. Front Immunol. 2022; 13:834981 Epub 2022 Jan 28
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11. Wilfahrt D, Philips RL, Lama J, Kizerwetter M, Shapiro MJ, McCue SA, Kennedy MM, Rajcula MJ, Zeng H, Shapiro VS. Histone deacetylase 3 represses cholesterol efflux during CD4(+) T-cell activation. Elife. 2021 Dec 2; 10 Epub 2021 Dec 02
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12. Zhu B, Wu Y, Huang S, Zhang R, Son YM, Li C, Cheon IS, Gao X, Wang M, Chen Y, Zhou X, Nguyen Q, Phan AT, Behl S, Taketo MM, Mack M, Shapiro VS, Zeng H, Ebihara H, Mullon JJ, Edell ES, Reisenauer JS, Demirel N, Kern RM, Chakraborty R, Cui W, Kaplan MH, Zhou X, Goldrath AW, Sun J. Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection. Immunity. 2021 Jun 8; 54 (6):1200-1218.e9 Epub 2021 May 04
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13. Zhou X, Zhu X, Li C, Li Y, Ye Z, Shapiro VS, Copland JA 3rd, Hitosugi T, Bernlohr DA, Sun J, Zeng H. Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity. Cell Rep. 2021 Jan 5; 34 (1):108601
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14. Liu Y, Jaquith JM, Mccarthy-Fruin K, Zhu X, Zhou X, Li Y, Crowson C, Davis JM 3rd, Thanarajasingam U, Zeng H. Immune checkpoint inhibitor-induced inflammatory arthritis: a novel clinical entity with striking similarities to seronegative rheumatoid arthritis. Clin Rheumatol. 2020 Dec; 39 (12):3631-3637 Epub 2020 May 30
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15. Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, Kc A, Vogel P, Chi H. Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Cell Metab. 2020 Dec 1; 32 (6):996-1011.e7 Epub 2020 Nov 17
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16. Du X, Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H. Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress. J Exp Med. 2020 Feb 3; 217 (2)
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17. Saravia J, Zeng H, Dhungana Y, Bastardo Blanco D, Nguyen TM, Chapman NM, Wang Y, Kanneganti A, Liu S, Raynor JL, Vogel P, Neale G, Carmeliet P, Chi H. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan; 6 (1):eaaw6443 Epub 2020 Jan 01
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18. Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB. Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. Haematologica. 2019 Sep; 104 (9):1731-1743 Epub 2019 Feb 21
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19. Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity. Nat Cell Biol. 2019 Jan; 21 (1):85-93 Epub 2019 Jan 02
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20. Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H. mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. Nat Commun. 2018 May 29; 9 (1):2095
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21. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Oncogenesis. 2018 Jan 24; 7 (1):9
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22. Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, Dhungana Y, Guy C, Neale G, Cloer C, Peng J, Wang D, Chi H. Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. Sci Adv. 2018 Jan; 4 (1):eaar5701 Epub 2018 Jan 31
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23. Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D. PLCgamma-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017 Nov 13; 8 (1):1457
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24. Zeng H. mTOR signaling in immune cells and its implications for cancer immunotherapy. Cancer Lett. 2017 Nov 1; 408:182-189 Epub 2017 Sept 06
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25. Zeng H, Chi H. mTOR signaling in the differentiation and function of regulatory and effector T cells Current opinion in immunology. 2017.
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26. Lewis Zhichang Shi, Jordy Saravia, Hu Zeng, Nishan S. Kalupahana, Clifford S. Guy, Geoffrey Neale, and Hongbo Chi.. Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes PNAS. 2017.
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27. Zeng H, Cohen S, Rathmell JC, Chi H. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation Immunity. 2016.
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28. Chaohong Liu, Nicole Chapman, Peer Karmaus, Zeng Hu, Hongbo Chi. mTOR and metabolic regulation of conventional and regulatory T cells. Journal of Leukocyte Biology. 2015.
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29. Hu Zeng , Hongbo Chi. Metabolic control of regulatory T cell development and function. Trends in Immunology. 2015. Epub 2015 Sep 20.
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30. Zeng H, Chi H. mTOR signaling and transcriptional regulation in T lymphocytes Transcription. 2014.
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31. Kai Yang, Sharad Shrestha, Hu Zeng, Peer W. F. Karmaus, Geoffrey Neale, Peter Vogel, David A. Guertin, Richard F. Lamb, Hongbo Chi.. T cell exit from quiescence and differentiation into Th2 cells depend on raptor-mTORC1-mediated metabolic reprogramming. Immunity. 2013.
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32. Zeng H, Chi H. The interplay between regulatory T cells and metabolic signals in immune regulation Oncoimmunology. 2013.
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33. Yanyan Wang, Guanghua Huang, Hu Zeng, Kai Yang, Richard F. Lamb, Hongbo Chi. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells PNAS. 2013.
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34. Hu Zeng , Kai Yang, Caryn Cloer, Geoffrey Neale, Peter Vogel, Hongbo Chi. mTORC1 couples immune signals and metabolic programming to establish Treg cell function. Nature. 2013.
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35. Zeng H, Chi H. mTOR and lymphocyte metabolism Current opinion in immunology. 2013.
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36. Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang T, Wen R, Hoffman A, Wang D. Nuclear Export of the NF-kB Inhibitor IkBa Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation Immunity. 2011.
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37. Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T. Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation Immunity. 2010.
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38. Hu Zeng , Yuhong Chen, Mei Yu, Liquan Xue, Xiang Gao, Stephan W. Morris, Demin Wang, and Renren Wen. TCR-mediated activation of CD4+CD44hi T cells bypasses Bcl10---An implication of differential NF-?B dependence of naïve and memory T cells during TCR-mediated responses Journal of Biological Chemistry. 2008.
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39. Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D. Bcl10 Plays a Divergent Role in NK Cell-Mediated Cytotoxicity and Cytokine Generation Journal of Immunology. 2007.
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40. Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, Lin X, Wen R. Phosphorylation of Bcl10 Negatively Regulates T-cell- receptor Mediated NF-?B Activation Molecular and Cellular Biology. 2007.
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41. Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D. B Cell Lymphoma 10 Is Essential for FcR-Mediated Degranulation and IL-6 Production in Mast Cells Journal of Immunology. 2007.
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42. Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, Zeng H, Yang C, Stephan RP, Cleveland JL, Wang D. Essential Role of Phospholipase C?? in Early B-Cell Development and Myc-Mediated Lymphomagenesis Molecular and Cellular Biology. 2006.
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43. Yu M, Sha H, Gao Y, Zeng H, Zhu M, Gao X. Alternative 3’UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression Biochemical and Biophysical Research Communications. 2006.
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44. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, Xu Q. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells American Journal of Pathology. 2004.
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