Publications

1. Chang S, Marsh JF Jr, Koons EK, Gong H, McCollough CH, Leng S. Improved noise reduction in photon-counting detector CT using prior knowledge-aware iterative denoising neural network. J Med Imaging (Bellingham). 2024 Dec; 11 (Suppl 1):S12804 Epub 2024 May 24
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2. Foley RA, Trentadue TP, Lopez C, Weber NM, Thoreson AR, Holmes DR 3rd, Murthy NS, Leng S, Kakar S, Zhao KD. Bilateral lunotriquetral coalition: a dynamic four-dimensional computed tomography technical case report. Skeletal Radiol. 2024 Jul; 53 (7):1423-1430 Epub 2023 Nov 09
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3. Trentadue TP, Thoreson AR, Lopez C, Breighner RE, An KN, Holmes DR 3rd, Moran SL, Kakar S, Murthy NS, Leng S, Zhao KD. Detection of scapholunate interosseous ligament injury using dynamic computed tomography-derived arthrokinematics: A prospective clinical trial. Med Eng Phys. 2024 Jun; 128:104172 Epub 2024 Apr 27
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4. Rajendran K, Bruesewitz M, Swicklik J, Ferrero A, Thorne J, Yu L, McCollough C, Leng S. Task-based automatic keV selection: leveraging routine virtual monoenergetic imaging for dose reduction on clinical photon-counting detector CT(). Phys Med Biol. 2024 May 21; 69 (11)
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5. Leng S, Toia GV, Hoodeshenas S, Ramirez-Giraldo JC, Yagil Y, Maltz JS, Boedeker K, Li K, Baffour F, Fletcher JG. Standardizing technical parameters and terms for abdominopelvic photon-counting CT: laying the groundwork for innovation and evidence sharing. Abdom Radiol (NY). 2024 May 20 [Epub ahead of print]
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6. Koons EK, Rajiah PS, Thorne JE, Weber NM, Kasten HJ, Shanblatt ER, McCollough CH, Leng S. Corrigendum to "Coronary artery stenosis quantification in patients with dense calcifications using ultra-high-resolution photon-counting-detector computed tomography" [J Cardiovasc Comput Tomogr 18 (2024) 56-61]. J Cardiovasc Comput Tomogr. 2024 May 20 [Epub ahead of print]
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7. Shunhavanich P, Mei K, Shapira N, Stayman JW, McCollough CH, Gang G, Leng S, Geagan M, Yu L, Noel PB, Hsieh SS. 3D printed phantom with 12 000 submillimeter lesions to improve efficiency in CT detectability assessment. Med Phys. 2024 May; 51 (5):3265-3274 Epub 2024 Apr 08
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8. Nelson BJ, Gomez-Cardona DG, Thorne JE, Huber NR, Yu L, Leng S, McCollough CH, Missert AD. Multiple Kernel Synthesis of Head CT Using a Task-Based Loss Function. J Imaging Inform Med. 2024 Apr; 37 (2):864-872 Epub 2024 Jan 12
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9. Doyle NS, Benson JC, Carr CM, Diehn FE, Carlson ML, Leng S, Lane JI. Photon Counting Versus Energy-integrated Detector CT in Detection of Superior Semicircular Canal Dehiscence. Clin Neuroradiol. 2024 Mar; 34 (1):251-255 Epub 2023 Dec 06
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10. Yalon M, Inoue A, Thorne JE, Lee YS, Johnson MP, Esquivel A, Leng S, McCollough CH, Fletcher JG, Rajiah PS. Infrapopliteal Segments on Lower Extremity CTA: Prospective Intraindividual Comparison of Energy-Integrating Detector CT and Photon-Counting Detector CT. AJR Am J Roentgenol. 2024 Mar; 222 (3):e2329778 Epub 2023 Nov 22
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11. Faghani S., Rhodes N., Patel S., Baffour F., Moassefi M., Rouzrokh P., Khosravi B., Powell G., Leng S., Glazebrook K., Erickson B., Tiegs-Heiden C.. Development of a Deep Learning Model for the Automated Detection of Green Pixels Indicative of Gout on Dual Energy CT scan Research in Diagnostic and Interventional Imaging. 2024.
    
12. Gong H, Ahmed Z, Chang S, Koons EK, Thorne JE, Rajiah P, Foley TA, Fletcher JG, McCollough CH, Leng S. Motion artifact correction in cardiac CT using cross-phase temporospatial information and synergistic attention gate and spatial transformer sub-networks. Phys Med Biol. 2024 Feb 2; 69 (3) Epub 2024 Feb 02
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13. Hsieh SS, Inoue A, Yalon M, Cook DA, Gong H, Sudhir Pillai P, Johnson MP, Fidler JL, Leng S, Yu L, Carter RE, Holmes DR 3rd, McCollough CH, Fletcher JG. Targeted Training Reduces Search Errors but Not Classification Errors for Hepatic Metastasis Detection at Contrast-Enhanced CT. Acad Radiol. 2024 Feb; 31 (2):448-456 Epub 2023 Aug 09
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14. Koons EK, Rajiah PS, Thorne JE, Weber NM, Kasten HJ, Shanblatt ER, McCollough CH, Leng S. Coronary artery stenosis quantification in patients with dense calcifications using ultra-high-resolution photon-counting-detector computed tomography. J Cardiovasc Comput Tomogr. 2024 Jan-Feb; 18 (1):56-61 Epub 2023 Nov 07
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15. McCollough CH, Rajiah P, Bois JP, Winfree TN, Carter RE, Rajendran K, Williamson EE, Thorne JE, Leng S. Comparison of Photon-counting Detector and Energy-integrating Detector CT for Visual Estimation of Coronary Percent Luminal Stenosis. Radiology. 2023 Dec; 309 (3):e230853
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16. Chang S, Ren L, Tang S, Marsh JF Jr, Hsieh S, McCollough CH, Leng S. Technical note: Exploring the detectability of coronary calcification using ultra-high-resolution photon-counting-detector CT. Med Phys. 2023 Nov; 50 (11):6836-6843 Epub 2023 Aug 31
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17. Ren L, Sun Y, Yeh B, Marsh JF, Winfree TN, Burke KA, Rajendran K, McCollough CH, Mileto A, Fletcher JG, Leng S. Characterization of single- and multi-energy CT performance of an oral dark borosilicate contrast media using a clinical photon-counting-detector CT platform. Med Phys. 2023 Nov; 50 (11):6779-6788 Epub 2023 Sept 05
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18. Nehra AK, Dane B, Yeh BM, Fletcher JG, Leng S, Mileto A. Dual-Energy, Spectral and Photon Counting Computed Tomography for Evaluation of the Gastrointestinal Tract. Radiol Clin North Am. 2023 Nov; 61 (6):1031-1049 Epub 2023 July 07
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19. Gomez-Cardona D, Favazza CP, Leng S, Schueler BA, Fetterly KA. Adaptation of a channelized Hotelling observer model to accommodate anthropomorphic backgrounds and moving test objects in X-ray angiography. Med Phys. 2023 Nov; 50 (11):6737-6747 Epub 2023 Sept 15
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20. McCollough CH, Winfree TN, Melka EF, Rajendran K, Carter RE, Leng S. Photon-Counting Detector Computed Tomography Versus Energy-Integrating Detector Computed Tomography for Coronary Artery Calcium Quantitation. J Comput Assist Tomogr. 2023 Oct 6 Epub 2023 Oct 06
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21. Chang S, Huber NR, Marsh JF, Koons EK, Gong H, Yu L, McCollough CH, Leng S. Pie-Net: Prior-information-enabled deep learning noise reduction for coronary CT angiography acquired with a photon counting detector CT. Med Phys. 2023 Oct; 50 (10):6283-6295 Epub 2023 Apr 11
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22. Rajiah PS, Dunning CAS, Rajendran K, Tandon YK, Ahmed Z, Larson NB, Collins JD, Thorne J, Williamson E, Fletcher JG, McCollough C, Leng S. High-Pitch Multienergy Coronary CT Angiography in Dual-Source Photon-Counting Detector CT Scanner at Low Iodinated Contrast Dose. Invest Radiol. 2023 Sep 1; 58 (9):681-690
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23. Chen JR, Winfree TN, Bruesewitz MR, Swicklik JR, Thorne JE, Leng S, McCollough CH. Technical Note: Assessment of Pulse Pileup on Single-Energy and Multienergy Images From a Clinical Photon-Counting Detector Computed Tomography. J Comput Assist Tomogr. 2023 Aug 11 [Epub ahead of print]
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24. McCollough CH, Rajendran K, Baffour FI, Diehn FE, Ferrero A, Glazebrook KN, Horst KK, Johnson TF, Leng S, Mileto A, Rajiah PS, Schmidt B, Yu L, Flohr TG, Fletcher JG. Clinical applications of photon counting detector CT. Eur Radiol. 2023 Aug; 33 (8):5309-5320 Epub 2023 Apr 05
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25. McCollough CH, Rajendran K, Leng S, Yu L, Fletcher JG, Stierstorfer K, Flohr TG. The technical development of photon-counting detector CT. Eur Radiol. 2023 Aug; 33 (8):5321-5330 Epub 2023 Apr 04
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26. Farnsworth PJ, Campeau NG, Diehn FE, Yu L, Leng S, Zhou Z, Fletcher JG, McCollough CH. High-resolution computed tomography angiography of the orbit using a photon-counting computed tomography scanner. Interv Neuroradiol. 2023 Jul 3; 15910199231175198 Epub 2023 July 03
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27. McCollough CH, Rajendran K, Leng S. Standardization and Quantitative Imaging With Photon-Counting Detector CT. Invest Radiol. 2023 Jul 1; 58 (7):451-458 Epub 2023 Jan 05
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28. Trentadue TP, Lopez C, Breighner RE, Akbari-Shandiz M, An KN, Leng S, Holmes DR 3rd, Moran SL, Kakar S, Smith J, Thoreson A, Zhao KD. Assessing carpal kinematics following scapholunate interosseous ligament injury ex vivo using four-dimensional dynamic computed tomography. Clin Biomech (Bristol, Avon). 2023 Jul; 107:106007 Epub 2023 May 22
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29. Ahmed Z, Ferrero A, Ren L, Vrieze TJ, Rajendran K, Favazza CP, Yu L, Bruesewitz MR, McCollough CH, Leng S. Establishing a quality assurance program for photon counting detector (PCD) CT: Tips and caveats. J Appl Clin Med Phys. 2023 Jul; 24 (7):e14074 Epub 2023 June 19
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30. Marsh JF Jr, VanMeter PD, Rajendran K, Leng S, McCollough CH. Ex vivo coronary calcium volume quantification using a high-spatial-resolution clinical photon-counting-detector computed tomography. J Med Imaging (Bellingham). 2023 Jul; 10 (4):043501 Epub 2023 July 04
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31. Koons EK, Thorne JE, Huber NR, Chang S, Rajendran K, McCollough CH, Leng S. Quantifying lumen diameter in coronary artery stents with high-resolution photon counting detector CT and convolutional neural network denoising. Med Phys. 2023 Jul; 50 (7):4173-4181 Epub 2023 Apr 17
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32. Oliver AA, Koons EK, Trester PS, Kleinow JE, Jonsgaard RS, Vercnocke AJ, Bilgin C, Kadirvel R, Leng S, Lu A, Dragomir-Daescu D, Kallmes DF. Medical Imaging Compatibility of Magnesium- and Iron-Based Bioresorbable Flow Diverters. AJNR Am J Neuroradiol. 2023 Jun; 44 (6):668-674 Epub 2023 May 11
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33. Trentadue TP, Lopez C, Breighner RE, Fautsch K, Leng S, Holmes Iii DR, Moran SL, Thoreson AR, Kakar S, Zhao KD. Evaluation of Scapholunate Injury and Repair with Dynamic (4D) CT: A Preliminary Report of Two Cases. J Wrist Surg. 2023 Jun; 12 (3):248-260 Epub 2023 Feb 09
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34. Nehra AK, Rajendran K, Baffour FI, Mileto A, Rajiah PS, Horst KK, Inoue A, Johnson TF, Diehn FE, Glazebrook KN, Thorne JE, Weber NM, Shanblatt ER, Gong H, Yu L, Leng S, McCollough CH, Fletcher JG. Seeing More with Less: Clinical Benefits of Photon-counting Detector CT. Radiographics. 2023 May; 43 (5):e220158
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35. Huber NR, Kim J, Leng S, McCollough CH, Yu L. Deep Learning-Based Image Noise Quantification Framework for Computed Tomography. J Comput Assist Tomogr. 2023 Apr 11 [Epub ahead of print]
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36. Baffour FI, Glazebrook KN, Ferrero A, Leng S, McCollough CH, Fletcher JG, Rajendran K. Photon-Counting Detector CT for Musculoskeletal Imaging: A Clinical Perspective. AJR Am J Roentgenol. 2023 Apr; 220 (4):551-560 Epub 2022 Oct 19
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37. Dunning CAS, Marsh JF Jr, Winfree T, Rajendran K, Leng S, Levin DL, Johnson TF, Fletcher JG, McCollough CH, Yu L. Accuracy of Nodule Volume and Airway Wall Thickness Measurement Using Low-Dose Chest CT on a Photon-Counting Detector CT Scanner. Invest Radiol. 2023 Apr 1; 58 (4):283-292 Epub 2022 Dec 13
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38. Ahmed Z, Campeau D, Gong H, Rajendran K, Rajiah P, McCollough C, Leng S. High-pitch, high temporal resolution, multi-energy cardiac imaging on a dual-source photon-counting-detector CT. Med Phys. 2023 Mar; 50 (3):1428-1435 Epub 2022 Dec 17
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39. Chen JR, Morris J, Wentworth A, Sears V, Duit A, Erie E, McGee K, Leng S. Three-dimensional printing accuracy analysis for medical applications across a wide variety of printers. J Med Imaging (Bellingham). 2023 Mar; 10 (2):026501 Epub 2023 Apr 03
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40. Dunning CAS, Rajendran K, Inoue A, Rajiah P, Weber N, Fletcher JG, McCollough CH, Leng S. Optimal Virtual Monoenergetic Photon Energy (keV) for Photon-Counting-Detector Computed Tomography Angiography. J Comput Assist Tomogr. 2023 Feb 10 [Epub ahead of print]
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41. Hsieh SS, Cook DA, Inoue A, Gong H, Sudhir Pillai P, Johnson MP, Leng S, Yu L, Fidler JL, Holmes DR 3rd, Carter RE, McCollough CH, Fletcher JG. Understanding Reader Variability: A 25-Radiologist Study on Liver Metastasis Detection at CT. Radiology. 2023 Feb; 306 (2):e220266 Epub 2022 Oct 04
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42. Toia GV, Zamora DA, Singleton M, Liu A, Tan E, Leng S, Shuman WP, Kanal KM, Mileto A. Detectability of Small Low-Attenuation Lesions With Deep Learning CT Image Reconstruction: A 24-Reader Phantom Study. AJR Am J Roentgenol. 2023 Feb; 220 (2):283-295 Epub 2022 Sept 21
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43. Huber NR, Missert AD, Gong H, Leng S, Yu L, McCollough CH. Technical note: Phantom-based training framework for convolutional neural network CT noise reduction. Med Phys. 2023 Feb; 50 (2):821-830 Epub 2022 Nov 26
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44. Rajendran K, Baffour F, Powell G, Glazebrook K, Thorne J, Larson N, Leng S, McCollough C, Fletcher J. Improved visualization of the wrist at lower radiation dose with photon-counting-detector CT. Skeletal Radiol. 2023 Jan; 52 (1):23-29 Epub 2022 July 13
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45. Chang CW, Charyyev S, Harms J, Slopsema R, Wolf J, Refai D, Yoon T, McDonald MW, Bradley JD, Leng S, Zhou J, Yang X, Lin L. A component method to delineate surgical spine implants for proton Monte Carlo dose calculation. J Appl Clin Med Phys. 2023 Jan; 24 (1):e13800 Epub 2022 Oct 09
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46. Baffour FI, Huber NR, Ferrero A, Rajendran K, Glazebrook KN, Larson NB, Kumar S, Cook JM, Leng S, Shanblatt ER, McCollough CH, Fletcher JG. Photon-counting Detector CT with Deep Learning Noise Reduction to Detect Multiple Myeloma. Radiology. 2023 Jan; 306(1):229-236. Epub 2022 Sep 06.
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47. Marsh JF Jr, Vercnocke AJ, Rajendran K, Tao S, Anderson JL, Ritman EL, Leng S, McCollough CH. Measurement of enhanced vasa vasorum density in a porcine carotid model using photon counting detector CT. J Med Imaging (Bellingham). 2023 Jan; 10 (1):016001 Epub 2023 Feb 06
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48. Macielak RJ, Benson JC, Lane JI, Carlson ML, Leng S. Photon-Counting Detector CT for Temporal Bone Imaging: Up to Three Times the Resolution at Half the Radiation Dose. Otol Neurotol. 2022 Dec 1; 43 (10):e1205-e1207 Epub 2022 Sept 16
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49. Inoue A, Johnson TF, White D, Cox CW, Hartman TE, Thorne JE, Shanblatt ER, Johnson MP, Carter RE, Lee YS, Rajendran K, Leng S, McCollough CH, Fletcher JG. Estimating the Clinical Impact of Photon-Counting-Detector CT in Diagnosing Usual Interstitial Pneumonia. Invest Radiol. 2022 Nov 1; 57 (11):734-741 Epub 2022 May 06
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50. Gong H, Baffour FI, Glazebrook KN, Rhodes NG, Tiegs-Heiden CA, Thorne JE, Cook JM, Kumar S, Fletcher JG, McCollough CH, Leng S. Deep learning-based virtual noncalcium imaging in multiple myeloma using dual-energy CT. Med Phys. 2022 Oct; 49 (10):6346-6358 Epub 2022 Aug 28
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51. Baffour FI, Rajendran K, Glazebrook KN, Thorne JE, Larson NB, Leng S, McCollough CH, Fletcher JG. Ultra-high-resolution imaging of the shoulder and pelvis using photon-counting-detector CT: a feasibility study in patients. Eur Radiol. 2022 Oct; 32 (10):7079-7086 Epub 2022 June 11
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52. Huls SJ, Shlapak DP, Kim DK, Leng S, Carr CM. Utility of Dual-Energy CT to Improve Diagnosis of CSF Leaks on CT Myelography following Lateral Decubitus Digital Subtraction Myelography with Negative Findings. AJNR Am J Neuroradiol. 2022 Oct; 43 (10):1539-1543 Epub 2022 Sept 08
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53. Huber NR, Ferrero A, Rajendran K, Baffour F, Glazebrook KN, Diehn FE, Inoue A, Fletcher JG, Yu L, Leng S, McCollough CH. Dedicated convolutional neural network for noise reduction in ultra-high-resolution photon-counting detector computed tomography. Phys Med Biol. 2022 Sep 2; 67 (17) Epub 2022 Sept 02
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54. Esquivel A, Ferrero A, Mileto A, Baffour F, Horst K, Rajiah PS, Inoue A, Leng S, McCollough C, Fletcher JG. Photon-Counting Detector CT: Key Points Radiologists Should Know. Korean J Radiol. 2022 Sep; 23 (9):854-865
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55. Pillai PS, Holmes DR 3rd, Carter R, Inoue A, Cook DA, Karwoski R, Fidler JL, Fletcher JG, Leng S, Yu L, McCollough CH, Hsieh SS. Individualized and generalized models for predicting observer performance on liver metastasis detection using CT. J Med Imaging (Bellingham). 2022 Sep; 9 (5):055501 Epub 2022 Sept 13
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56. Hsieh SS, Leng S, Yu L, Huber NR, McCollough CH. A minimum SNR criterion for computed tomography object detection in the projection domain. Med Phys. 2022 Aug; 49 (8):4988-4998 Epub 2022 July 10
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57. Mohammadinejad P, Khandelwal A, Inoue A, Takahashi H, Yalon M, Long Z, Halaweish AF, Leng S, Yu L, Lee YS, McCollough CH, Fletcher JG. Utility of an automatic adaptive iterative metal artifact reduction AiMAR algorithm in improving CT imaging of patients with hip prostheses evaluated for suspected bladder malignancy. Abdom Radiol (NY). 2022 Jun; 47 (6):2158-2167 Epub 2022 Mar 23
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58. Tao S, Gong H, Michalak G, McCollough C, Leng S, Hu Y. Technical note: Evaluation of artificial 120-kilovolt computed tomography images for radiation therapy applications. Med Phys. 2022 Jun; 49 (6):3683-3691 Epub 2022 Apr 21
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59. McCollough CH, McCollough SL, Schneider JJ, Moen TR, Weaver JM, Vrieze TJ, Yu L, Leng S. Dependence of Water-equivalent Diameter and Size-specific Dose Estimates on CT Tube Potential. Radiology. 2022 May; 303 (2):404-411 Epub 2022 Jan 18
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60. Benson JC, Rajendran K, Lane JI, Diehn FE, Weber NM, Thorne JE, Larson NB, Fletcher JG, McCollough CH, Leng S. A New Frontier in Temporal Bone Imaging: Photon-Counting Detector CT Demonstrates Superior Visualization of Critical Anatomic Structures at Reduced Radiation Dose. AJNR Am J Neuroradiol. 2022 Apr; 43 (4):579-584 Epub 2022 Mar 24
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61. Rajendran K, Petersilka M, Henning A, Shanblatt ER, Schmidt B, Flohr TG, Ferrero A, Baffour F, Diehn FE, Yu L, Rajiah P, Fletcher JG, Leng S, McCollough CH. First Clinical Photon-counting Detector CT System: Technical Evaluation. Radiology. 2022 Apr; 303 (1):130-138 Epub 2021 Dec 14
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62. Gong H, Fletcher JG, Heiken JP, Wells ML, Leng S, McCollough CH, Yu L. Deep-learning model observer for a low-contrast hepatic metastases localization task in computed tomography. Med Phys. 2022 Jan; 49 (1):70-83 Epub 2021 Dec 01
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63. Huber N, Anderson T, Missert A, Adkins M, Leng S, Fletcher J, McCollough C, Yu L, Glazebrook KN. Clinical evaluation of a phantom-based deep convolutional neural network for whole-body-low-dose and ultra-low-dose CT skeletal surveys. Skeletal Radiol. 2022 Jan; 51 (1):145-151 Epub 2021 June 10
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64. Rajiah PS, Weber N, Loewen J, Kasten H, Williamson E, Moore A, Leng S. Dynamic CT Angiography in Vascular Imaging: Principles and Applications. Radiographics. 2022 Nov-Dec; 42(7):E224-E225. Epub 2022 Sep 30.
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65. Inoue A, Vrtiska TJ, Lee YS, Vasconcelos RN, Weber NM, Halaweish AF, Duba I, Williamson EE, Leng S, McCollough CH, Fletcher JG. The feasibility of low iodine dynamic CT angiography with test bolus for evaluation of lower extremity peripheral artery disease. Vascular. 2021 Dec; 29(6):927-937. Epub 2021 Jan 17.
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66. Gong H, Hsieh SS, Holmes DR 3rd, Cook DA, Inoue A, Bartlett DJ, Baffour F, Takahashi H, Leng S, Yu L, McCollough CH, Fletcher JG. An interactive eye-tracking system for measuring radiologists' visual fixations in volumetric CT images: Implementation and initial eye-tracking accuracy validation. Med Phys. 2021 Nov; 48 (11):6710-6723 Epub 2021 Oct 06
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67. Rajendran K, Petersilka M, Henning A, Shanblatt E, Marsh J Jr, Thorne J, Schmidt B, Flohr T, Fletcher J, McCollough C, Leng S. Full field-of-view, high-resolution, photon-counting detector CT: technical assessment and initial patient experience. Phys Med Biol. 2021 Oct 27; 66 (20)
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68. Mohammadinejad P, Mileto A, Yu L, Leng S, Guimaraes LS, Missert AD, Jensen CT, Gong H, McCollough CH, Fletcher JG. CT Noise-Reduction Methods for Lower-Dose Scanning: Strengths and Weaknesses of Iterative Reconstruction Algorithms and New Techniques. Radiographics. 2021 Sep-Oct; 41 (5):1493-1508
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69. Gong H, Marsh JF, D'Souza KN, Huber NR, Rajendran K, Fletcher JG, McCollough CH, Leng S. Deep-learning-based direct synthesis of low-energy virtual monoenergetic images with multi-energy CT. J Med Imaging (Bellingham). 2021 Sep; 8 (5):052104 Epub 2021 Apr 19
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70. Sandstedt M, Marsh J Jr, Rajendran K, Gong H, Tao S, Persson A, Leng S, McCollough C. Improved coronary calcification quantification using photon-counting-detector CT: an ex vivo study in cadaveric specimens. Eur Radiol. 2021 Sep; 31 (9):6621-6630 Epub 2021 Mar 13
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71. Gong H, Yu L, Leng S, Fletcher JG, McCollough CH. Reader Performance as a Function of Patient Size for the Detection of Hepatic Metastases. J Comput Assist Tomogr. 2021 Aug 2 Epub 2021 Aug 02
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72. Ding YH, Abbasi M, Michalak G, Leng S, Dai D, Fitzgerald S, Kadirvel R, Kallmes DF, Brinjikji W. Characterization of thrombus composition with multimodality CT-based imaging: an in-vitro study. J Neurointerv Surg. 2021 Aug; 13 (8):738-740 Epub 2020 Oct 28
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73. Gong H, Tao S, Gagneur JD, Liu W, Shen J, McCollough CH, Hu Y, Leng S. Implementation and experimental evaluation of Mega-voltage fan-beam CT using a linear accelerator. Radiat Oncol. 2021 Jul 28; 16 (1):139 Epub 2021 July 28
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74. Hsieh SS, Leng S, Rajendran K, Tao S, McCollough CH. Photon Counting CT: Clinical Applications and Future Developments. IEEE Trans Radiat Plasma Med Sci. 2021 Jul; 5 (4):441-452 Epub 2020 Aug 28
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75. Gomez-Cardona D, Favazza CP, Leng S, Schueler BA, Fetterly KA. Task-specific efficient channel selection and bias management for Gabor function channelized Hotelling observer model for the assessment of x-ray angiography system performance. Med Phys. 2021 Jul; 48 (7):3638-3653 Epub 2021 May 30
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76. D'Souza RS, Li L, Leng S, Hunt C, Law L, Muir C, Eldrige J, Bydon M, Chi M, Shapiro S, Mauck WD, Qu W. A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest. Bosn J Basic Med Sci. 2021 Jun 1; 21 (3):370-377 Epub 2021 June 01
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77. Tao S, Sheedy E, Bruesewitz M, Weber N, Williams K, Halaweish A, Schmidt B, Williamson E, McCollough C, Leng S. Technical Note: kV-independent coronary calcium scoring: A phantom evaluation of score accuracy and potential radiation dose reduction. Med Phys. 2021 Mar; 48(3):1307-1314. Epub 2021 Jan 09.
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78. Hu Y, Ding X, Shen J, Bues M, Liu W, Kang Y, Leng S, Yu L. Feasibility of using megavoltage computed tomography to reduce proton range uncertainty: A simulation study. J Appl Clin Med Phys. 2021 Mar; 22 (3):131-140 Epub 2021 Feb 20
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79. Nelson BJ, Leng S, Shanblatt ER, McCollough CH, Koenig T. Empirical beam hardening and ring artifact correction for x-ray grating interferometry (EBHC-GI). Med Phys. 2021 Mar; 48 (3):1327-1340 Epub 2021 Jan 10
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80. Moen TR, Chen B, Holmes DR 3rd, Duan X, Yu Z, Yu L, Leng S, Fletcher JG, McCollough CH. Low-dose CT image and projection dataset. Med Phys. 2021 Feb; 48 (2):902-911 Epub 2020 Dec 16
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81. Inoue A, Johnson TF, Voss BA, Lee YS, Leng S, Koo CW, McCollough BD, Weaver JM, Gong H, Carter RE, McCollough CH, Fletcher JG. A Pilot Study to Estimate the Impact of High Matrix Image Reconstruction on Chest Computed Tomography. J Clin Imaging Sci. 2021; 11:52 Epub 2021 Sept 30
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82. Long Z, Kurup AN, Jensen NM, Hangiandreou NJ, Schueler BA, Yu L, Leng S, Wood CP, Felmlee JP. Initial testing of pegfilgrastim (Neulasta Onpro) on-body injector in multiple radiological imaging environments. J Appl Clin Med Phys. 2021 Jan; 22 (1):343-349 Epub 2021 Jan 04
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83. Fletcher JG, Levin DL, Sykes AG, Lindell RM, White DB, Kuzo RS, Suresh V, Yu L, Leng S, Holmes DR 3rd, Inoue A, Johnson MP, Carter RE, McCollough CH. Observer Performance for Detection of Pulmonary Nodules at Chest CT over a Large Range of Radiation Dose Levels. Radiology. 2020 Dec; 297(3):699-707. Epub 2020 Sep 29.
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84. Gong H, Tao S, Rajendran K, Zhou W, McCollough CH, Leng S. Deep-learning-based direct inversion for material decomposition. Med Phys. 2020 Dec; 47 (12):6294-6309 Epub 2020 Oct 30
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85. Tao S, Rajendran K, Zhou W, Fletcher JG, McCollough CH, Leng S. Noise reduction in CT image using prior knowledge aware iterative denoising. Phys Med Biol. 2020 Nov 19; 65 (22)
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86. Rizvi A, Marcus RP, Guo Y, Carter R, Mark IT, Foley TA, Weber NM, Sheedy EN, Leng S, Williamson EE. Dynamic computed tomographic assessment of the mitral annulus in patients with and without mitral prolapse. J Cardiovasc Comput Tomogr. 2020 Nov-Dec; 14 (6):502-509 Epub 2020 Feb 27
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87. Lee O, Rajendran K, Polster C, Stierstorfer K, Kappler S, Leng S, McCollough CH, Taguchi K. X-ray Transmittance Modeling-based Material Decomposition using a Photon-counting Detector CT System IEEE Transactions on Radiation and Plasma Medical Sciences. 2020.
    
88. Rajiah P, Parakh A, Kay F, Baruah D, Kambadakone AR, Leng S. Update on Multienergy CT: Physics, Principles, and Applications. Radiographics. 2020 Sep-Oct; 40 (5):1284-1308 Epub 2020 Aug 21
    View PubMed
89. Li Z, Leng S, Halaweish AF, Yu Z, Yu L, Ritman EL, McCollough CH. Overcoming calcium blooming and improving the quantification accuracy of percent area luminal stenosis by material decomposition of multi-energy computed tomography datasets. J Med Imaging (Bellingham). 2020 Sep; 7 (5):053501 Epub 2020 Oct 01
    View PubMed
90. Tao S, Marsh JF, Tao A, Michalak GJ, Rajendran K, McCollough CH, Leng S. Multi-energy CT imaging for large patients using dual-source photon-counting detector CT. Phys Med Biol. 2020 Aug 31; 65 (17):17NT01
    View PubMed
91. Jacobsen MC, Thrower SL, Ger RB, Leng S, Court LE, Brock KK, Tamm EP, Cressman ENK, Cody DD, Layman RR. Multi-energy computed tomography and material quantification: Current barriers and opportunities for advancement. Med Phys. 2020 Aug; 47 (8):3752-3771 Epub 2020 June 23
    View PubMed
92. Gong H, Hu Q, Walther A, Koo CW, Takahashi EA, Levin DL, Johnson TF, Hora MJ, Leng S, Fletcher JG, McCollough CH, Yu L. Deep-learning-based model observer for a lung nodule detection task in computed tomography. J Med Imaging (Bellingham). 2020 Jul; 7 (4):042807 Epub 2020 June 30
    View PubMed
93. Rajendran K, Murthy NS, Frick MA, Tao S, Unger MD, LaVallee KT, Larson NB, Leng S, Maus TP, McCollough CH. Quantitative Knee Arthrography in a Large Animal Model of Osteoarthritis Using Photon-Counting Detector CT. Invest Radiol. 2020 Jun; 55 (6):349-356
    View PubMed
94. Taparra K, Lester SC, Harmsen WS, Petersen M, Funk RK, Blanchard MJ, Young P, Herrmann J, Hunzeker A, Schultz H, McCollough C, Tasson A, Leng S, Martenson JA, Whitaker TJ, Williamson E, Laack NN. Reducing Heart Dose with Protons and Cardiac Substructure Sparing for Mediastinal Lymphoma Treatment. Int J Part Ther. 2020 Summer; 7 (1):1-12 Epub 2020 Sept 04
    View PubMed
95. Zhou W, Michalak GJ, Weaver JM, Gong H, Yu L, McCollough CH, Leng S. A Universal Protocol for Abdominal CT Examinations Performed on a Photon-Counting Detector CT System: A Feasibility Study. Invest Radiol. 2020 Apr; 55 (4):226-232
    View PubMed
96. Lester SC, Taparra K, Petersen MM, Funk RK, Blanchard MJ, Young PM, Herrmann J, Hunzeker AE, Schultz HL, McCollough C, Tasson AM, Leng S, Martenson JA, Deisher AJ, Whitaker TJ, Williamson EE, Laack NN. Electrocardiogram-Gated Computed Tomography with Coronary Angiography for Cardiac Substructure Delineation and Sparing in Patients with Mediastinal Lymphomas Treated with Radiation Therapy. Pract Radiat Oncol. 2020 Mar - Apr; 10 (2):104-111 Epub 2019 Nov 26
    View PubMed
97. Missert AD, Yu L, Leng S, Fletcher JG, McCollough CH. Synthesizing images from multiple kernels using a deep convolutional neural network. Med Phys. 2020 Feb; 47 (2):422-430 Epub 2019 Dec 29
    View PubMed
98. Rajendran K, Voss BA, Zhou W, Tao S, DeLone DR, Lane JI, Weaver JM, Carlson ML, Fletcher JG, McCollough CH, Leng S. Dose Reduction for Sinus and Temporal Bone Imaging Using Photon-Counting Detector CT With an Additional Tin Filter. Invest Radiol. 2020 Feb; 55 (2):91-100
    View PubMed
99. Baffour FI, Glazebrook KN, Morris JM, Michalak GJ, Fletcher JG, Leng S, McCollough CH. Clinical utility of virtual noncalcium dual-energy CT in imaging of the pelvis and hip. Skeletal Radiol. 2019 Dec; 48 (12):1833-1842 Epub 2019 May 30
    View PubMed
100. Samei E, Bakalyar D, Boedeker KL, Brady S, Fan J, Leng S, Myers KJ, Popescu LM, Ramirez Giraldo JC, Ranallo F, Solomon J, Vaishnav J, Wang J. Performance evaluation of computed tomography systems: Summary of AAPM Task Group 233. Med Phys. 2019 Nov; 46 (11):e735-e756 Epub 2019 Sept 11
     View PubMed
101. Fletcher JG, DeLone DR, Kotsenas AL, Campeau NG, Lehman VT, Yu L, Leng S, Holmes DR 3rd, Edwards PK, Johnson MP, Michalak GJ, Carter RE, McCollough CH. Evaluation of Lower-Dose Spiral Head CT for Detection of Intracranial Findings Causing Neurologic Deficits. AJNR Am J Neuroradiol. 2019 Nov; 40 (11):1855-1863 Epub 2019 Oct 24
     View PubMed
102. Sheikhzadeh M, Vercnocke AJ, Tao S, Rajendran K, Leng S, Ritman EL, McCollough CH. Impact of Effective Detector Pixel and CT Voxel Size on Accurate Estimation of Blood Volume in Opacified Microvasculature. Acad Radiol. 2019 Oct; 26 (10):1410-1416 Epub 2018 Dec 07
     View PubMed
103. Navin PJ, Kim B, Wells ML, Khandelwal A, Halaweish AF, Moen TR, Johnson MP, McCollough S, Lee YS, Leng S, McCollough CH, Fletcher JG. Reducing radiation dose for multi-phase contrast-enhanced dual energy renal CT: pilot study evaluating prior iterative reconstruction. Abdom Radiol (NY). 2019 Oct; 44(10):3350-3358.
     View PubMed
104. Zhou W, Michalak G, Weaver J, Ferrero A, Gong H, Fetterly KA, McCollough CH, Leng S. Determination of iodine detectability in different types of multiple-energy images for a photon-counting detector computed tomography system. J Med Imaging (Bellingham). 2019 Oct; 6 (4):043501 Epub 2019 Oct 15
     View PubMed
105. Tao S, Rajendran K, McCollough CH, Leng S. Feasibility of multi-contrast imaging on dual-source photon counting detector (PCD) CT: An initial phantom study. Med Phys. 2019 Sep; 46 (9):4105-4115 Epub 2019 July 05
     View PubMed
106. Morris J, Michalak G, Leng S, Moynagh M, Kurup AN, McCollough C, Fletcher J. Dual-Energy CT Monitoring of Cryoablation Zone Growth in the Spinal Column and Bony Pelvis: A Laboratory Study. J Vasc Interv Radiol. 2019 Sep; 30 (9):1496-1503 Epub 2019 May 18
     View PubMed
107. Tao A, Huang R, Tao S, Michalak GJ, McCollough CH, Leng S. Dual-source photon counting detector CT with a tin filter: a phantom study on iodine quantification performance. Phys Med Biol. 2019 May 31; 64 (11):115019
     View PubMed
108. Tao S, Rajendran K, Zhou W, Fletcher JG, McCollough CH, Leng S. Improving iodine contrast to noise ratio using virtual monoenergetic imaging and prior-knowledge-aware iterative denoising (mono-PKAID). Phys Med Biol. 2019 May 16; 64 (10):105014
     View PubMed
109. Dilger SKN, Yu L, Chen B, Favazza CP, Carter RE, Fletcher JG, McCollough CH, Leng S. Localization of liver lesions in abdominal CT imaging: I. Correlation of human observer performance between anatomical and uniform backgrounds. Phys Med Biol. 2019 May 10; 64 (10):105011
     View PubMed
110. Dilger SKN, Leng S, Chen B, Carter RE, Favazza CP, Fletcher JG, McCollough CH, Yu L. Localization of liver lesions in abdominal CT imaging: II. Mathematical model observer performance correlates with human observer performance for localization of liver lesions in abdominal CT imaging. Phys Med Biol. 2019 May 10; 64 (10):105012
     View PubMed
111. Gong H, Yu L, Leng S, Dilger SK, Ren L, Zhou W, Fletcher JG, McCollough CH. A deep learning- and partial least square regression-based model observer for a low-contrast lesion detection task in CT. Med Phys. 2019 May; 46 (5):2052-2063 Epub 2019 Apr 01
     View PubMed
112. Leng S, Bruesewitz M, Tao S, Rajendran K, Halaweish AF, Campeau NG, Fletcher JG, McCollough CH. Photon-counting Detector CT: System Design and Clinical Applications of an Emerging Technology. Radiographics. 2019 May-Jun; 39 (3):729-743
     View PubMed
113. Glazebrook KN, Doerge S, Leng S, Drees TA, Hunt KN, Zingula SN, Pruthi S, Geske JR, Carter RE, McCollough CH, Fletcher JG. Ability of Dual-Energy CT to Detect Silicone Gel Breast Implant Rupture and Nodal Silicone Spread. AJR Am J Roentgenol. 2019 Apr; 212 (4):933-942 Epub 2019 Feb 19
     View PubMed
114. Zhou W, Bartlett DJ, Diehn FE, Glazebrook KN, Kotsenas AL, Carter RE, Fletcher JG, McCollough CH, Leng S. Reduction of Metal Artifacts and Improvement in Dose Efficiency Using Photon-Counting Detector Computed Tomography and Tin Filtration. Invest Radiol. 2019 Apr; 54 (4):204-211
     View PubMed
115. Bartlett DJ, Koo CW, Bartholmai BJ, Rajendran K, Weaver JM, Halaweish AF, Leng S, McCollough CH, Fletcher JG. High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography. Invest Radiol. 2019 Mar; 54 (3):129-137
     View PubMed
116. Shanblatt ER, Sung Y, Gupta R, Nelson BJ, Leng S, Graves WS, McCollough CH. Forward model for propagation-based x-ray phase contrast imaging in parallel- and cone-beam geometry. Opt Express. 2019 Feb 18; 27 (4):4504-4521
     View PubMed
117. Gong H, Walther A, Hu Q, Koo CW, Takahashi EA, Levin DL, Johnson TF, Hora MJ, Leng S, Fletcher JG, McCollough CH, Yu L. Correlation between a deep-learning-based model observer and human observer for a realistic lung nodule localization task in chest CT Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019; 10952:109520K. Epub 1900 Jan 01.
     
118. Marcus RP, Fletcher JG, Ferrero A, Leng S, Halaweish AF, Gutjahr R, Vrtiska TJ, Wells ML, Enders FT, McCollough CH. Detection and Characterization of Renal Stones by Using Photon-Counting-based CT. Radiology. 2018 Nov; 289 (2):436-442 Epub 2018 Aug 07
     View PubMed
119. Fletcher JG, Fidler JL, Venkatesh SK, Hough DM, Takahashi N, Yu L, Johnson M, Leng S, Holmes DR 3rd, Carter R, McCollough CH. Observer Performance with Varying Radiation Dose and Reconstruction Methods for Detection of Hepatic Metastases. Radiology. 2018 Nov; 289(2):455-464. Epub 2018 Sep 11.
     View PubMed
120. Leng S, Rajendran K, Gong H, Zhou W, Halaweish AF, Henning A, Kappler S, Baer M, Fletcher JG, McCollough CH. 150-mum Spatial Resolution Using Photon-Counting Detector Computed Tomography Technology: Technical Performance and First Patient Images. Invest Radiol. 2018 Nov; 53 (11):655-662
     View PubMed
121. Marsh JF, Jorgensen SM, Rundle DS, Vercnocke AJ, Leng S, Butler PH, McCollough CH, Ritman EL. Evaluation of a photon counting Medipix3RX cadmium zinc telluride spectral x-ray detector. J Med Imaging (Bellingham). 2018 Oct; 5 (4):043503 Epub 2018 Dec 04
     View PubMed
122. Leng S. Radiation Dose in CT-guided Interventional Procedures: Establishing a Benchmark. Radiology 2018 Oct; 289 (1):158-159 Epub 2018 July 17
     View PubMed
123. Ferrero A, Gutjahr R, Halaweish AF, Leng S, McCollough CH. Characterization of Urinary Stone Composition by Use of Whole-body, Photon-counting Detector CT. Acad Radiol. 2018 Oct; 25 (10):1270-1276 Epub 2018 Feb 14
     View PubMed
124. Tao S, Rajendran K, McCollough CH, Leng S. Material decomposition with prior knowledge aware iterative denoising (MD-PKAID). Phys Med Biol. 2018 Sep 21; 63 (19):195003 Epub 2018 Sept 21
     View PubMed
125. Zhou W, Lane JI, Carlson ML, Bruesewitz MR, Witte RJ, Koeller KK, Eckel LJ, Carter RE, McCollough CH, Leng S. Comparison of a Photon-Counting-Detector CT with an Energy-Integrating-Detector CT for Temporal Bone Imaging: A Cadaveric Study. AJNR Am J Neuroradiol. 2018 Sep; 39 (9):1733-1738 Epub 2018 Aug 09
     View PubMed
126. Samreen N, Glazebrook KN, Bhatt A, Venkatesh SK, McMenomy BP, Chandra A, Leng S, Adler KE, McCollough CH. Imaging findings of mammary and systemic silicone deposition secondary to breast implants. Br J Radiol. 2018 Sep; 91 (1089):20180098 Epub 2018 May 10
     View PubMed
127. Yu L, Ren L, Li Z, Leng S, McCollough CH. Dual-source multienergy CT with triple or quadruple x-ray beams. J Med Imaging (Bellingham). 2018 Jul; 5 (3):033502 Epub 2018 July 24
     View PubMed
128. Long Z, Bruesewitz MR, DeLone DR, Morris JM, Amrami KK, Adkins MC, Glazebrook KN, Kofler JM, Leng S, McCollough CH, Fletcher JG, Halaweish AF, Yu L. Evaluation of projection- and dual-energy-based methods for metal artifact reduction in CT using a phantom study. J Appl Clin Med Phys. 2018 Jul; 19 (4):252-260 Epub 2018 May 10
     View PubMed
129. Hanson GJ, Michalak GJ, Childs R, McCollough B, Kurup AN, Hough DM, Frye JM, Fidler JL, Venkatesh SK, Leng S, Yu L, Halaweish AF, Harmsen WS, McCollough CH, Fletcher JG. Low kV versus dual-energy virtual monoenergetic CT imaging for proven liver lesions: what are the advantages and trade-offs in conspicuity and image quality? A pilot study. Abdom Radiol (NY). 2018 Jun; 43 (6):1404-1412
     View PubMed
130. Zhou W, Montoya J, Gutjahr R, Ferrero A, Halaweish A, Kappler S, McCollough C, Leng S. Lung nodule volume quantification and shape differentiation with an ultra-high resolution technique on a photon-counting detector computed tomography system. J Med Imaging (Bellingham). 2017 Oct; 4 (4):043502 Epub 2017 Nov 16
     View PubMed
131. Rajendran K, Leng S, Jorgensen SM, Anderson JL, Halaweish AF, Abdurakhimova D, Ritman EL, McCollough CH. Measuring arterial wall perfusion using photon-counting computed tomography (CT): improving CT number accuracy of artery wall using image deconvolution. J Med Imaging (Bellingham). 2017 Oct; 4 (4):044006 Epub 2017 Dec 08
     View PubMed
132. Sung Y, Gupta R, Nelson B, Leng S, McCollough CH, Graves WS. Phase-contrast imaging with a compact x-ray light source: system design. J Med Imaging (Bellingham). 2017 Oct; 4 (4):043503 Epub 2017 Nov 23
     View PubMed
133. McCollough CH, Bartley AC, Carter RE, Chen B, Drees TA, Edwards P, Holmes DR 3rd, Huang AE, Khan F, Leng S, McMillan KL, Michalak GJ, Nunez KM, Yu L, Fletcher JG. Low-dose CT for the detection and classification of metastatic liver lesions: Results of the 2016 Low Dose CT Grand Challenge. Med Phys. 2017 Oct; 44 (10):e339-e352
     View PubMed
134. Michalak G, Grimes J, Fletcher J, Halaweish A, Yu L, Leng S, McCollough C. Selection of optimal tube potential settings for dual-energy CT virtual mono-energetic imaging of iodine in the abdomen. Abdom Radiol (NY). 2017 Sep; 42 (9):2289-2296
     View PubMed
135. Leng S, Zhou W, Yu Z, Halaweish A, Krauss B, Schmidt B, Yu L, Kappler S, McCollough C. Spectral performance of a whole-body research photon counting detector CT: quantitative accuracy in derived image sets. Phys Med Biol. 2017 Aug 21; 62 (17):7216-7232
     View PubMed
136. Wells ML, Froemming AT, Kawashima A, Vrtiska TJ, Kim B, Hartman RP, Holmes DR 3rd, Carter RE, Bartley AC, Leng S, McCollough CH, Fletcher JG. A multi-reader in vitro study using porcine kidneys to determine the impact of integrated circuit detectors and iterative reconstruction on the detection accuracy, size measurement, and radiation dose for small (<4 mm) renal stones. Acta Radiol. 2017 Aug; 58: (8)1012-1019.
     View PubMed
137. Yu L, Chen B, Kofler JM, Favazza CP, Leng S, Kupinski MA, McCollough CH. Correlation between a 2D channelized Hotelling observer and human observers in a low-contrast detection task with multislice reading in CT. Med Phys. 2017 Aug; 44 (8):3990-3999 Epub 2017 July 13
     View PubMed
138. Carlson ML, Leng S, Diehn FE, Witte RJ, Krecke KN, Grimes J, Koeller KK, Bruesewitz MR, McCollough CH, Lane JI. Cochlear Implant Electrode Localization Using an Ultra-High Resolution Scan Mode on Conventional 64-Slice and New Generation 192-Slice Multi-Detector Computed Tomography. Otol Neurotol. 2017 Aug; 38 (7):978-984
     View PubMed
139. McMillan K, Bostani M, Cagnon CH, Yu L, Leng S, McCollough CH, McNitt-Gray MF. Estimating patient dose from CT exams that use automatic exposure control: Development and validation of methods to accurately estimate tube current values. Med Phys. 2017 Aug; 44 (8):4262-4275 Epub 2017 June 30
     View PubMed
140. Fletcher JG, Yu L, Fidler JL, Levin DL, DeLone DR, Hough DM, Takahashi N, Venkatesh SK, Sykes AG, White D, Lindell RM, Kotsenas AL, Campeau NG, Lehman VT, Bartley AC, Leng S, Holmes DR 3rd, Toledano AY, Carter RE, McCollough CH. Estimation of Observer Performance for Reduced Radiation Dose Levels in CT: Eliminating Reduced Dose Levels That Are Too Low Is the First Step. Acad Radiol. 2017 Jul; 24 (7):876-890 Epub 2017 Mar 02
     View PubMed
141. Favazza CP, Ferrero A, Yu L, Leng S, McMillan KL, McCollough CH. Use of a channelized Hotelling observer to assess CT image quality and optimize dose reduction for iteratively reconstructed images. J Med Imaging (Bellingham). 2017 Jul; 4 (3):031213 Epub 2017 Oct 03
     View PubMed
142. Huang AE, Montoya JC, Shiung M, Leng S, McCollough CH. Consistency of Renal Stone Volume Measurements Across CT Scanner Model and Reconstruction Algorithm Configurations. AJR Am J Roentgenol. 2017 Jul; 209 (1):116-121 Epub 2017 Apr 12
     View PubMed
143. Brinjikji W, Michalak G, Kadirvel R, Dai D, Gilvarry M, Duffy S, Kallmes DF, McCollough C, Leng S. Utility of single-energy and dual-energy computed tomography in clot characterization: An in-vitro study. Interv Neuroradiol. 2017 Jun; 23 (3):279-284 Epub 2017 Jan 01
     View PubMed
144. Leng S, Takahashi N, Gomez Cardona D, Kitajima K, McCollough B, Li Z, Kawashima A, Leibovich BC, McCollough CH. Subjective and objective heterogeneity scores for differentiating small renal masses using contrast-enhanced CT. Abdom Radiol (NY). 2017 May; 42 (5):1485-1492
     View PubMed
145. Li Z, Leng S, Yu L, Manduca A, McCollough CH. An effective noise reduction method for multi-energy CT images that exploit spatio-spectral features. Med Phys. 2017 May; 44 (5):1610-1623 Epub 2017 Apr 12
     View PubMed
146. Li Z, Leng S, Yu Z, Kappler S, McCollough CH. Estimation of signal and noise for a whole-body research photon-counting CT system. J Med Imaging (Bellingham). 2017 Apr; 4 (2):023505 Epub 2017 June 22
     View PubMed
147. Hobbs BD, de Jong K, Lamontagne M, Bosse Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Pare PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH, COPDGene Investigators//ECLIPSE Investigators//LifeLines Investigators//SPIROMICS Research Group//International COPD Genetics Network Investigators//UK BiLEVE Investigators//International COPD Genetics Consortium. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar; 49 (3):426-432 Epub 2017 Feb 06
     View PubMed
148. Doerge S, Glazebrook ,, Leng S, McCollough C. Utility of Dual-Energy Computed Tomography for Evaluation of Silicone within Internal Mammary Nodes Austin J Clin Case Rep.2017;4:(1):1112.
     
149. Marcus RP, Morris JM, Matsumoto JM, Alexander AE, Halaweish AF, Kelly JA, Fletcher JG, McCollough CH, Leng S. Implementation of iterative metal artifact reduction in the pre-planning-procedure of three-dimensional physical modeling. 3D Print Med. 2017; 3(1):5. Epub 2017 Mar 31.
     View PubMed
150. Ma C, Yu L, Chen B, Koo CW, Takahashi EA, Fletcher JG, Levin DL, Kuzo RS, Viers LD, Vincent-Sheldon SA, Leng S, McCollough CH. Evaluation of a projection-domain lung nodule insertion technique in thoracic computed tomography. J Med Imaging (Bellingham). 2017 Jan; 4 (1):013510 Epub 2017 Mar 31
     View PubMed
151. Leng S, McGee K, Morris J, Alexander A, Kuhlmann J, Vrieze T, McCollough CH, Matsumoto J. Anatomic modeling using 3D printing: quality assurance and optimization. 3D Print Med. 2017; 3(1):6. Epub 2017 Apr 26.
     View PubMed
152. Long Z, Bruesewitz MR, Sheedy EN, Powell MA, Kramer JC, Supalla RR, Colvin CM, Bechel JR, Favazza CP, Kofler JM, Leng S, McCollough CH, Yu L. Technical Note: Display window setting: An important factor for detecting subtle but clinically relevant artifacts in daily CT quality control. Med Phys. 2016 Dec; 43(12):6413.
     View PubMed
153. Kakar S, Breighner RE, Leng S, McCollough CH, Moran SL, Berger RA, Zhao KD. The Role of Dynamic (4D) CT in the Detection of Scapholunate Ligament Injury. J Wrist Surg. 2016 Nov; 5 (4):306-310 Epub 2016 Jan 18
     View PubMed
154. Chen B, Ma C, Leng S, Fidler JL, Sheedy SP, McCollough CH, Fletcher JG, Yu L. Validation of a Projection-domain Insertion of Liver Lesions into CT Images. Acad Radiol. 2016 Oct; 23 (10):1221-9 Epub 2016 July 16
     View PubMed
155. Leng S, Yu Z, Halaweish A, Kappler S, Hahn K, Henning A, Li Z, Lane J, Levin DL, Jorgensen S, Ritman E, McCollough C. Dose-efficient ultrahigh-resolution scan mode using a photon counting detector computed tomography system. J Med Imaging (Bellingham). 2016 Oct; 3 (4):043504 Epub 2016 Dec 22
     View PubMed
156. Yu Z, Leng S, Kappler S, Hahn K, Li Z, Halaweish AF, Henning A, McCollough CH. Noise performance of low-dose CT: comparison between an energy integrating detector and a photon counting detector using a whole-body research photon counting CT scanner. J Med Imaging (Bellingham). 2016 Oct; 3 (4):043503 Epub 2016 Dec 14
     View PubMed
157. Yu Z, Leng S, Li Z, McCollough CH. Spectral prior image constrained compressed sensing (spectral PICCS) for photon-counting computed tomography. Phys Med Biol. 2016 Sep 21; 61 (18):6707-6732 Epub 2016 Aug 23
     View PubMed
158. Grimes J, Leng S, Zhang Y, Vrieze T, McCollough C. Implementation and evaluation of a protocol management system for automated review of CT protocols. J Appl Clin Med Phys. 2016 Sep 8; 17 (5):523-533 Epub 2016 Sept 08
     View PubMed
159. Leng S, Huang A, Cardona JM, Duan X, Williams JC, McCollough CH. Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study. AJR Am J Roentgenol. 2016 Aug; 207 (2):321-9 Epub 2016 May 25
     View PubMed
160. Leng S, Chen B, Vrieze T, Kuhlmann J, Yu L, Alexander A, Matsumoto J, Morris J, McCollough CH. Construction of realistic phantoms from patient images and a commercial three-dimensional printer. J Med Imaging (Bellingham). 2016 Jul; 3(3):033501. Epub 2016 Jul 07.
     View PubMed
161. Yu Z, Leng S, Li Z, Halaweish AF, Kappler S, Ritman EL, McCollough CH. How Low Can We Go in Radiation Dose for the Data-Completion Scan on a Research Whole-Body Photon-Counting Computed Tomography System. J Comput Assist Tomogr. 2016 Jul-Aug; 40 (4):663-70
     View PubMed
162. Gutjahr R, Halaweish AF, Yu Z, Leng S, Yu L, Li Z, Jorgensen SM, Ritman EL, Kappler S, McCollough CH. Human Imaging With Photon Counting-Based Computed Tomography at Clinical Dose Levels: Contrast-to-Noise Ratio and Cadaver Studies. Invest Radiol. 2016 Jul; 51 (7):421-9
     View PubMed
163. Takahashi N, Takeuchi M, Sasaguri K, Leng S, Froemming A, Kawashima A. CT negative attenuation pixel distribution and texture analysis for detection of fat in small angiomyolipoma on unenhanced CT. Abdom Radiol (NY). 2016 Jun; 41 (6):1142-51
     View PubMed
164. Ma C, Yu L, Chen B, Favazza C, Leng S, McCollough C. Impact of number of repeated scans on model observer performance for a low-contrast detection task in computed tomography. J Med Imaging (Bellingham). 2016 Apr; 3 (2):023504 Epub 2016 May 26
     View PubMed
165. Fletcher JG, Leng S, Yu L, McCollough CH. Dealing with Uncertainty in CT Images. Radiology 2016 Apr; 279 (1):5-10
     View PubMed
166. Yu Z, Leng S, Jorgensen SM, Li Z, Gutjahr R, Chen B, Halaweish AF, Kappler S, Yu L, Ritman EL, McCollough CH. Evaluation of conventional imaging performance in a research whole-body CT system with a photon-counting detector array. Phys Med Biol. 2016 Feb 21; 61 (4):1572-95 Epub 2016 Feb 02
     View PubMed
167. McEachen JC, Leng S, Atwell TD, Tollefson MK, Friese JL, Wang Z, Murad MH, Schmit GD. Percutaneous Renal Tumor Ablation: Radiation Exposure During Cryoablation and Radiofrequency Ablation. Cardiovasc Intervent Radiol. 2016 Feb; 39: (2)233-8.
     View PubMed
168. Breighner R, Holmes DR 3rd, Leng S, An KN, McCollough C, Zhao K. Relative accuracy of spin-image-based registration of partial capitate bones in 4DCT of the wrist. Comput Methods Biomech Biomed Eng Imaging Vis. 2016; 4 (6):360-367 Epub 2014 Aug 12
     View PubMed
169. Glazebrook KN, Leng S, Jacobson SR, McCollough CM. Dual-Energy CT for Evaluation of Intra- and Extracapsular Silicone Implant Rupture. Case Rep Radiol. 2016; 2016:6323709 Epub 2016 Jan 28
     View PubMed
170. Li Z, Yu L, Leng S, Williamson EE, Kotsenas AL, DeLone DR, Manduca A, McCollough CH. A robust noise reduction technique for time resolved CT. Med Phys. 2016 Jan; 43: (1)347.
     View PubMed
171. Michalak G, Grimes J, Fletcher J, Halaweish A, Yu L, Leng S, McCollough C. Technical Note: Improved CT number stability across patient size using dual-energy CT virtual monoenergetic imaging. Med Phys. 2016 Jan; 43: (1)513.
     View PubMed
172. Wells ML, Froemming AT, Kawashima A, Vrtiska TJ, Kim B, Hartman RP, Holmes III DR, Carter RE, Bartley AC, Leng S, McCollough CH, Fletcher JG. A multi-reader in vitro study using porcine kidneys to determine the impact of integrated circuit detectors and iterative reconstruction on the detection accuracy, size measurement, and radiation dose for small (<4mm) renal stones Acta Radiologica.2016;0:(0)1-8.
     
173. Takahashi N, Leng S, Kitajima K, Gomez-Cardona D, Thapa P, Carter RE, Leibovich BC, Sasiwimonphan K, Sasaguri K, Kawashima A. Small (< 4 cm) Renal Masses: Differentiation of Angiomyolipoma Without Visible Fat From Renal Cell Carcinoma Using Unenhanced and Contrast-Enhanced CT. AJR Am J Roentgenol. 2015 Dec; 205(6):1194-202.
     View PubMed
174. Duan X, Li Z, Yu L, Leng S, Halaweish AF, Fletcher JG, McCollough CH. Characterization of Urinary Stone Composition by Use of Third-Generation Dual-Source Dual-Energy CT With Increased Spectral Separation. AJR Am J Roentgenol. 2015 Dec; 205 (6):1203-7
     View PubMed
175. Chen B, Leng S, Yu L, Yu Z, Ma C, McCollough C. Lesion insertion in the projection domain: Methods and initial results. Med Phys. 2015 Dec; 42 (12):7034-42
     View PubMed
176. Chen B, Duan X, Yu Z, Leng S, Yu L, McCollough C. Technical Note: Development and validation of an open data format for CT projection data. Med Phys. 2015 Dec; 42 (12):6964-72
     View PubMed
177. Favazza CP, Duan X, Zhang Y, Yu L, Leng S, Kofler JM, Bruesewitz MR, McCollough CH. A cross-platform survey of CT image quality and dose from routine abdomen protocols and a method to systematically standardize image quality. Phys Med Biol. 2015 Nov 7; 60 (21):8381-97 Epub 2015 Oct 13
     View PubMed
178. Sasaguri K, Takahashi N, Gomez-Cardona D, Leng S, Schmit GD, Carter RE, Leibovich BC, Kawashima A. Small (< 4 cm) Renal Mass: Differentiation of Oncocytoma From Renal Cell Carcinoma on Biphasic Contrast-Enhanced CT. AJR Am J Roentgenol. 2015 Nov; 205: (5)999-1007.
     View PubMed
179. Matsumoto JS, Morris JM, Foley TA, Williamson EE, Leng S, McGee KP, Kuhlmann JL, Nesberg LE, Vrtiska TJ. Three-dimensional Physical Modeling: Applications and Experience at Mayo Clinic. Radiographics 2015 Nov-Dec; 35 (7):1989-2006
     View PubMed
180. Grimes J, Duan X, Yu L, Halaweish AF, Haag N, Leng S, McCollough C. The influence of focal spot blooming on high-contrast spatial resolution in CT imaging. Med Phys. 2015 Oct; 42: (10)6011-20.
     View PubMed
181. McCollough CH, Leng S, Yu L, Fletcher JG. Dual- and Multi-Energy CT: Principles, Technical Approaches, and Clinical Applications. Radiology. 2015 Sep; 276 (3):637-53
     View PubMed
182. Leng S, Diehn FE, Lane JI, Koeller KK, Witte RJ, Carter RE, McCollough CH. Temporal Bone CT: Improved Image Quality and Potential for Decreased Radiation Dose Using an Ultra-High-Resolution Scan Mode with an Iterative Reconstruction Algorithm. AJNR Am J Neuroradiol. 2015 Sep; 36 (9):1599-603 Epub 2015 May 21
     View PubMed
183. McCollough CH, Yu L, Kofler JM, Leng S, Zhang Y, Li Z, Carter RE. Degradation of CT Low-Contrast Spatial Resolution Due to the Use of Iterative Reconstruction and Reduced Dose Levels. Radiology. 2015 Aug; 276 (2):499-506 Epub 2015 Mar 26
     View PubMed
184. Leng S, Yu L, Fletcher JG, McCollough CH. Maximizing Iodine Contrast-to-Noise Ratios in Abdominal CT Imaging through Use of Energy Domain Noise Reduction and Virtual Monoenergetic Dual-Energy CT. Radiology. 2015 Aug; 276 (2):562-70 Epub 2015 Apr 10
     View PubMed
185. Fletcher JG, Yu L, Li Z, Manduca A, Blezek DJ, Hough DM, Venkatesh SK, Brickner GC, Cernigliaro JC, Hara AK, Fidler JL, Lake DS, Shiung M, Lewis D, Leng S, Augustine KE, Carter RE, Holmes DR 3rd, McCollough CH. Observer Performance in the Detection and Classification of Malignant Hepatic Nodules and Masses with CT Image-Space Denoising and Iterative Reconstruction. Radiology. 2015 Aug; 276 (2):465-78 Epub 2015 May 26
     View PubMed
186. Qu M, Yu L, Cardona DG, Liu Y, Duan X, Ai S, Leng S, Shiung M, McCollough CH. Radiation Dose Reduction in Dual-Energy CT: Does It Affect the Accuracy of Urinary Stone Characterization? AJR Am J Roentgenol. 2015 Aug; 205 (2):W172-6
     View PubMed
187. Zhao K, Breighner R, Holmes D III, Leng S, McCollough C, An KN. A technique for quantifying wrist motion using four-dimensional computed tomography: approach and validation. Journal Of Biomechanical Engineering-Transactions Of The Asme. 2015 Jul; 137(7):074501.
     
188. Kofler JM, Yu L, Leng S, Zhang Y, Li Z, Carter RE, McCollough CH. Assessment of Low-Contrast Resolution for the American College of Radiology Computed Tomographic Accreditation Program: What Is the Impact of Iterative Reconstruction? J Comput Assist Tomogr. 2015 Jul-Aug; 39 (4):619-23
     View PubMed
189. Leng S, Shiung M, Duan X, Yu L, Zhang Y, McCollough CH. Size-specific Dose Estimates for Chest, Abdominal, and Pelvic CT: Effect of Intrapatient Variability in Water-equivalent Diameter. Radiology. 2015 Jul; 276 (1):184-90 Epub 2015 Feb 25
     View PubMed
190. Prasad M, Tweet MS, Hayes SN, Leng S, Liang JJ, Eleid MF, Gulati R, Vrtiska TJ. Prevalence of extracoronary vascular abnormalities and fibromuscular dysplasia in patients with spontaneous coronary artery dissection. Am J Cardiol. 2015 Jun 15; 115 (12):1672-7 Epub 2015 Mar 23
     View PubMed
191. Bongartz T, Glazebrook KN, Kavros SJ, Murthy NS, Merry SP, Franz WB 3rd, Michet CJ, Veetil BM, Davis JM 3rd, Mason TG 2nd, Warrington KJ, Ytterberg SR, Matteson EL, Crowson CS, Leng S, McCollough CH. Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study. Ann Rheum Dis. 2015 Jun; 74 (6):1072-7 Epub 2014 Mar 25
     View PubMed
192. Favazza CP, Yu L, Leng S, Kofler JM, McCollough CH. Automatic exposure control systems designed to maintain constant image noise: effects on computed tomography dose and noise relative to clinically accepted technique charts. J Comput Assist Tomogr. 2015 May-Jun; 39 (3):437-42
     View PubMed
193. Yu L, Vrieze TJ, Leng S, Fletcher JG, McCollough CH. Technical Note: Measuring contrast- and noise-dependent spatial resolution of an iterative reconstruction method in CT using ensemble averaging. Med Phys. 2015 May; 42 (5):2261-7
     View PubMed
194. Leng S, Hruska CB, McCollough CH. Use of ionizing radiation in screening examinations for coronary artery calcium and cancers of the lung, colon, and breast. Semin Roentgenol. 2015 Apr; 50: (2)148-60.
     View PubMed
195. Miller WL, Behrenbeck TR, McCollough CH, Williamson EE, Leng S, Kline TL, Ritman EL. Coronary microcirculation changes in non-ischemic dilated cardiomyopathy identified by novel perfusion CT. Int J Cardiovasc Imaging. 2015 Apr; 31 (4):881-8 Epub 2015 Feb 25
     View PubMed
196. Glazebrook K, Guerra Bonilla FL, Johnson A, Leng S, Dispenzieri A. Computed tomography assessment of bone lesions in patients with POEMS syndrome. Eur Radiol. 2015 Feb; 25 (2):497-504 Epub 2014 Sept 25
     View PubMed
197. Leng S, Shiung M, Ai S, Qu M, Vrtiska TJ, Grant KL, Krauss B, Schmidt B, Lieske JC, McCollough CH. Feasibility of discriminating uric acid from non-uric acid renal stones using consecutive spatially registered low- and high-energy scans obtained on a conventional CT scanner. AJR Am J Roentgenol. 2015 Jan; 204 (1):92-7
     View PubMed
198. Favazza CP, Fetterly KA, Hangiandreou NJ, Leng S, Schueler BA. Implementation of a channelized Hotelling observer model to assess image quality of x-ray angiography systems. J Med Imaging (Bellingham). 2015 Jan; 2 (1):015503 Epub 2015 Mar 25
     View PubMed
199. McCollough C, Bakalyar DM, Bostani M, Brady S, Boedeker K, Boone JM, Chen-Mayer HH, Christianson OI, Leng S, Li B, McNitt-Gray MF, Nilsen RA, Supanich MP, Wang J. Use of Water Equivalent Diameter for Calculating Patient Size and Size-Specific Dose Estimates (SSDE) in CT: The Report of AAPM Task Group 220. AAPM Rep. 2014 Sep; 2014:6-23
     View PubMed
200. Ai S, Qu M, Glazebrook KN, Liu Y, Rhee PC, Leng S, McCollough CH. Use of dual-energy CT and virtual non-calcium techniques to evaluate post-traumatic bone bruises in knees in the subacute setting. Skeletal Radiol. 2014 Sep; 43 (9):1289-95 Epub 2014 June 10
     View PubMed
201. Maus T, Schueler BA, Leng S, Magnuson D, Magnuson DJ, Diehn FE. Radiation dose incurred in the exclusion of vascular filling in transforaminal epidural steroid injections: fluoroscopy, digital subtraction angiography, and CT/fluoroscopy. Pain Med. 2014 Aug; 15(8):1328-33. Epub 2014 Jun 24.
     View PubMed
202. Zhang Y, Leng S, Yu L, Carter RE, McCollough CH. Correlation between human and model observer performance for discrimination task in CT. Phys Med Biol. 2014 Jul 7; 59 (13):3389-404 Epub 2014 May 30
     View PubMed
203. Liang JJ, Prasad M, Tweet MS, Hayes SN, Gulati R, Breen JF, Leng S, Vrtiska TJ. A novel application of CT angiography to detect extracoronary vascular abnormalities in patients with spontaneous coronary artery dissection. J Cardiovasc Comput Tomogr. 2014 May-Jun; 8 (3):189-97 Epub 2014 Apr 04
     View PubMed
204. Liu Y, Leng S, Michalak GJ, Vrieze TJ, Duan X, Qu M, Shiung MM, McCollough CH, Fletcher JG. Reducing image noise in computed tomography (CT) colonography: effect of an integrated circuit CT detector. J Comput Assist Tomogr. 2014 May-Jun; 38: (3)398-403.
     View PubMed
205. Howard ME, McCollough CH, Leng S, Yu L, Bruesewitz MR. Use of CT dose notification and alert values in routine clinical practice. J Am Coll Radiol. 2014 May; 11(5):450-5. Epub 2014 Mar 19.
     View PubMed
206. Goto A, Leng S, Sugamoto K, Cooney WP 3rd, Kakar S, Zhao K. In vivo pilot study evaluating the thumb carpometacarpal joint during circumduction. Clin Orthop Relat Res. 2014 Apr; 472 (4):1106-13
     View PubMed
207. Glazebrook KN, Brewerton LJ, Leng S, Carter RE, Rhee PC, Murthy NS, Howe BM, Ringler MD, Dahm DL, Stuart MJ, McCollough CH, Fletcher JG. Case-control study to estimate the performance of dual-energy computed tomography for anterior cruciate ligament tears in patients with history of knee trauma. Skeletal Radiol. 2014 Mar; 43 (3):297-305 Epub 2013 Dec 14
     View PubMed
208. Behrenbeck TR, McCollough CH, Miller WL, Williamson EE, Leng S, Kline TL, Ritman EL. Early changes in myocardial microcirculation in asymptomatic hypercholesterolemic subjects: as detected by perfusion CT. Ann Biomed Eng. 2014 Mar; 42: (3)515-25.
     View PubMed
209. Zhu X, Zhang J, Fan W, Gong Y, Yan J, Yuan Z, Wu L, Cui H, Luo H, Kong Q, Tang L, Leng S, Liao Y, Fu W, Xiao Q, Li D. MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. PLoS One. 2014; 9 (8):e105995 Epub 2014 Aug 25
     View PubMed
210. Jepperson MA, Cernigliaro JG, Sella D, Ibrahim E, Thiel DD, Leng S, Haley WE. Dual-energy CT for the evaluation of urinary calculi: image interpretation, pitfalls and stone mimics. Clin Radiol. 2013 Dec; 68: (12)e707-14.
     View PubMed
211. Liu Y, Qu M, Carter RE, Leng S, Ramirez-Giraldo JC, Jaramillo G, Krambeck AE, Lieske JC, Vrtiska TJ, McCollough CH. Differentiating calcium oxalate and hydroxyapatite stones in vivo using dual-energy CT and urine supersaturation and pH values. Acad Radiol. 2013 Dec; 20 (12):1521-5
     View PubMed
212. Duan X, Wang J, Leng S, Schmidt B, Allmendinger T, Grant K, Flohr T, McCollough CH. Electronic noise in CT detectors: Impact on image noise and artifacts. AJR Am J Roentgenol. 2013 Oct; 201 (4):W626-32
     View PubMed
213. Leng S, Yu L, Zhang Y, Carter R, Toledano AY, McCollough CH. Correlation between model observer and human observer performance in CT imaging when lesion location is uncertain. Med Phys. 2013 Aug; 40 (8):081908
     View PubMed
214. Yu L, Fletcher JG, Grant KL, Carter RE, Hough DM, Barlow JM, Vrtiska TJ, Williamson EE, Young PM, Goss BC, Shiung M, Leng S, Raupach R, Schmidt B, Flohr T, McCollough CH. Automatic selection of tube potential for radiation dose reduction in vascular and contrast-enhanced abdominopelvic CT. AJR Am J Roentgenol. 2013 Aug; 201 (2):W297-306
     View PubMed
215. Del Gaizo AJ, Fletcher JG, Yu L, Paden RG, Spencer GC, Leng S, Silva AM, Fidler JL, Silva AC, Hara AK. Reducing radiation dose in CT enterography. Radiographics. 2013 Jul-Aug; 33 (4):1109-24
     View PubMed
216. Froemming AT, Kawashima A, Takahashi N, Hartman RP, Nathan MA, Carter RE, Yu L, Leng S, Kagoshima H, McCollough CH, Fletcher JG. Individualized kV selection and tube current reduction in excretory phase computed tomography urography: potential for radiation dose reduction and the contribution of iterative reconstruction to image quality. J Comput Assist Tomogr. 2013 Jul-Aug; 37(4):551-9.
     View PubMed
217. Hough DM, Yu L, Shiung MM, Carter RE, Geske JR, Leng S, Fidler JL, Huprich JE, Jondal DY, McCollough CH, Fletcher JG. Individualization of abdominopelvic CT protocols with lower tube voltage to reduce i.v. contrast dose or radiation dose. AJR Am J Roentgenol. 2013 Jul; 201 (1):147-53
     View PubMed
218. McCollough CH, Leng S, Sunnegardh J, Vrieze TJ, Yu L, Lane J, Raupach R, Stierstorfer K, Flohr T. Spatial resolution improvement and dose reduction potential for inner ear CT imaging using a z-axis deconvolution technique. Med Phys. 2013 Jun; 40 (6):061904
     View PubMed
219. Yu L, Leng S, Chen L, Kofler JM, Carter RE, McCollough CH. Prediction of human observer performance in a 2-alternative forced choice low-contrast detection task using channelized Hotelling observer: impact of radiation dose and reconstruction algorithms. Med Phys. 2013 Apr; 40 (4):041908
     View PubMed
220. Wang J, Qu M, Duan X, Takahashi N, Kawashima A, Leng S, McCollough CH. Characterisation of urinary stones in the presence of iodinated contrast medium using dual-energy CT: a phantom study. Eur Radiol. 2012 Dec; 22 (12):2589-96 Epub 2012 Aug 04
     View PubMed
221. Yu L, Leng S, McCollough CH. Dual-energy CT-based monochromatic imaging. AJR Am J Roentgenol. 2012 Nov; 199 (5 Suppl):S9-S15
     View PubMed
222. Wang J, Christner JA, Duan X, Leng S, Yu L, McCollough CH. Attenuation-based estimation of patient size for the purpose of size specific dose estimation in CT. Part II. Implementation on abdomen and thorax phantoms using cross sectional CT images and scanned projection radiograph images. Med Phys. 2012 Nov; 39: (11)6772-8.
     View PubMed
223. Wang J, Duan X, Christner JA, Leng S, Yu L, McCollough CH. Attenuation-based estimation of patient size for the purpose of size specific dose estimation in CT. Part I. Development and validation of methods using the CT image. Med Phys. 2012 Nov; 39 (11):6764-71
     View PubMed
224. Duan X, Wang J, Qu M, Leng S, Liu Y, Krambeck A, McCollough C. Kidney stone volume estimation from computerized tomography images using a model based method of correcting for the point spread function. J Urol. 2012 Sep; 188 (3):989-95 Epub 2012 July 21
     View PubMed
225. McCollough CH, Chen GH, Kalender W, Leng S, Samei E, Taguchi K, Wang G, Yu L, Pettigrew RI. Achieving routine submillisievert CT scanning: report from the summit on management of radiation dose in CT. Radiology. 2012 Aug; 264 (2):567-80 Epub 2012 June 12
     View PubMed
226. Chen L, Sykes A, Jensen E, Eiken P, Yu L, Leng S, McCollough C. SU-D-217BCD-04: How Do We Know How Low Can We Go in Lung Cancer Screening CT? Med Phys. 2012 Jun; 39 (6Part3):3619
     View PubMed
227. Leng S, Chen L, Shu Y, McCollough C. WE-D-213AB-03: Preparing for the ABR Diagnostic Medical Physics Board Exams - Oral Exam. Med Phys. 2012 Jun; 39 (6Part27):3954
     View PubMed
228. Chen GH, Theriault-Lauzier P, Tang J, Nett B, Leng S, Zambelli J. Time-Resolved Interventional Cardiac C-arm Cone-Beam CT: An Application of the PICCS Algorithm. IEEE Transactions on Medical Imaging. 2012 Apr; 31(4).
     
229. Del Gaizo A, Fletcher J, Yu L, Paden R, Spencer G, Leng S, Silva A. Reducing Radiation Dose in Computed Tomography Enterography. Radiographics. 2012 Apr.
     
230. Glazebrook KN, Kakar S, Ida CM, Laurini JA, Moder KG, Leng S. False-negative dual-energy computed tomography in a patient with acute gout. J Clin Rheumatol. 2012 Apr; 18: (3)138-41.
     View PubMed
231. Hartman R, Kawashima A, Takahashi N, Silva A, Vrtiska T, Leng S, Fletcher J, McCollough C. Applications of dual-energy CT in urologic imaging: an update. Radiol Clin North Am. 2012 Mar; 50: (2)191-205, v.
     View PubMed
232. Froemming A, Kawashima A, Takahashi N, Hartman R, Nathan M, Carter R, Yu L, Leng S, etc. Individualized kV selection and tube curent reduction in excretory phase CT urography: Potential for radiation dose reduction and the contribution of iterative reconstruction to image quality. JCAT. 2012.
     
233. Wang J, Duan X, Christner JA, Leng S, Grant KL, McCollough CH. Bismuth shielding, organ-based tube current modulation, and global reduction of tube current for dose reduction to the eye at head CT. Radiology. 2012 Jan; 262(1):191-8.
     View PubMed
234. Yu L, Christner JA, Leng S, Wang J, Fletcher JG, McCollough CH. Virtual monochromatic imaging in dual-source dual-energy CT: radiation dose and image quality. Med Phys. 2011 Dec; 38 (12):6371-9
     View PubMed
235. Wang J, Garg N, Duan X, Liu Y, Leng S, Yu L, Ritman EL, Kantor B, McCollough CH. Quantification of iron in the presence of calcium with dual-energy computed tomography (DECT) in an ex vivo porcine plaque model. Phys Med Biol. 2011 Nov 21; 56: (22)7305-16.
     View PubMed
236. Wang J, Duan X, Christner JA, Leng S, Yu L, McCollough CH. Radiation dose reduction to the breast in thoracic CT: comparison of bismuth shielding, organ-based tube current modulation, and use of a globally decreased tube current. Med Phys. 2011 Nov; 38: (11)6084-92.
     View PubMed
237. Glazebrook KN, Guimaraes LS, Murthy NS, Black DF, Bongartz T, Manek NJ, Leng S, Fletcher JG, McCollough CH. Identification of intraarticular and periarticular uric acid crystals with dual-energy CT: initial evaluation. Radiology. 2011 Nov; 261 (2):516-24 Epub 2011 Sept 16
     View PubMed
238. Leng S, Yu L, Wang J, Fletcher JG, Mistretta CA, McCollough CH. Noise reduction in spectral CT: reducing dose and breaking the trade-off between image noise and energy bin selection. Med Phys. 2011 Sep; 38: (9)4946-57.
     View PubMed
239. Duan X, Wang J, Christner JA, Leng S, Grant KL, McCollough CH. Dose reduction to anterior surfaces with organ-based tube-current modulation: evaluation of performance in a phantom study. AJR Am J Roentgenol. 2011 Sep; 197 (3):689-95
     View PubMed
240. Leng S, Zhao K, Qu M, An KN, Berger R, McCollough CH. Dynamic CT technique for assessment of wrist joint instabilities. Med Phys. 2011 Jul; 38 Suppl 1:S50
     View PubMed
241. Leng S, Christner JA, Carlson SK, Jacobsen M, Vrieze TJ, Atwell TD, McCollough CH. Radiation dose levels for interventional CT procedures. AJR Am J Roentgenol. 2011 Jul; 197 (1):W97-103
     View PubMed
242. Qu M, Ramirez-Giraldo JC, Leng S, Williams JC, Vrtiska TJ, Lieske JC, McCollough CH. Dual-energy dual-source CT with additional spectral filtration can improve the differentiation of non-uric acid renal stones: an ex vivo phantom study. AJR Am J Roentgenol. 2011 Jun; 196 (6):1279-87
     View PubMed
243. McCollough CH, Leng S, Yu L, Cody DD, Boone JM, McNitt-Gray MF. CT dose index and patient dose: they are not the same thing. Radiology 2011 May; 259 (2):311-6
     View PubMed
244. Leng S, Atwell TD, Yu L, Mandrekar J, Lewis BD, Woodrum DA, McCollough CH. Radiation dose reduction for CT-guided renal tumor cryoablation. AJR Am J Roentgenol. 2011 May; 196: (5)W586-91.
     View PubMed
245. Ramirez-Giraldo JC, Trzasko J, Leng S, Yu L, Manduca A, McCollough CH. Nonconvex prior image constrained compressed sensing (NCPICCS): theory and simulations on perfusion CT. Med Phys. 2011 Apr; 38 (4):2157-67
     View PubMed
246. Duan X, Wang J, Yu L, Leng S, McCollough CH. CT scanner x-ray spectrum estimation from transmission measurements. Med Phys. 2011 Feb; 38 (2):993-7
     View PubMed
247. Vrtiska TJ, Krambeck AE, McCollough CH, Leng S, Qu M, Yu L, Lieske JC. Imaging evaluation and treatment of nephrolithiasis: an update. Minn Med. 2010 Aug; 93 (8):48-51
     View PubMed
248. Chen Gh, Tang J, Nett B, Qi Z, Leng S, Szczykutowicz T. Prior Image Contrained Compressed Sensing (PICCS) and Applications in X-ray Computed Tomography. Current Medical Imaging Reveiws. 2010; 6:119-134.
     
249. Flohr TG, Leng S, Yu L, Aiimendinger T, Bruder H, Petersilka M, Eusemann CD, Stierstorfer K, Schmidt B, McCollough CH. Dual-source spiral CT with pitch up to 3.2 and 75 ms temporal resolution: image reconstruction and assessment of image quality. Med Phys. 2009 Dec; 36 (12):5641-53
     View PubMed
250. Yu L, Liu X, Leng S, Kofler JM, Ramirez-Giraldo JC, Qu M, Christner J, Fletcher JG, McCollough CH. Radiation dose reduction in computed tomography: techniques and future perspective. Imaging Med. 2009 Oct; 1 (1):65-84
     View PubMed
251. Leng S, Tang J, Zambelli J, Nett B, Tolakanahalli R, Chen GH. High temporal resolution and streak-free four-dimensional cone-beam computed tomography. Phys Med Biol. 2008 Oct 21; 53(20):5653-73. Epub 2008 Sep 24.
     View PubMed
252. Leng S, Zambelli J, Tolakanahalli R, Nett B, Munro P, Star-Lack J, Paliwal B, Chen GH. Streaking artifacts reduction in four-dimensional cone-beam computed tomography. Med Phys. 2008 Oct; 35(10):4649-59.
     View PubMed
253. Nett BE, Leng S, Zambelli JN, Reeder SB, Speidel MA, Chen GH. Temporally targeted imaging method applied to ECG-gated computed tomography: preliminary phantom and in vivo experience. Acad Radiol. 2008 Jan; 15(1):93-106.
     View PubMed
254. Chen GH, Zhuang T, Leng S, Nett BE. Cone-beam filtered backprojection image reconstruction using a factorized weighting function. Opt Eng. 2007 Aug; 46(8):87006.
     
255. Leng S, Zhuang T, Nett BE, Chen GH. Helical cone-beam computed tomography image reconstruction algorithm for a tilted gantry with N-PI data acquisition. Opt Eng. 2007 Jan; 46(1):15004.
     
256. Nett BE, Zhuang TL, Leng S, Chen GH. Arc based cone-beam reconstruction algorithm using an equal weighting scheme. J Xray Sci Technol. 2007; 15(1):19-48.
     
257. Zhuang T, Nett BE, Leng S, Chen GH. A shift-invariant filtered backprojection (FBP) cone-beam reconstruction algorithm for the source trajectory of two concentric circles using an equal weighting scheme. Phys Med Biol. 2006 Jun 21; 51(12):3189-210. Epub 2006 Jun 06.
     View PubMed
258. Leng S, Zhuang T, Nett BE, Chen GH. Exact fan-beam image reconstruction algorithm for truncated projection data acquired from an asymmetric half-size detector. Phys Med Biol. 2005 Apr 21; 50(8):1805-20. Epub 2005 Apr 06.
     View PubMed
259. Chen GH, Leng S. A new data consistency condition for fan-beam projection data. Med Phys. 2005 Apr; 32(4):961-7.
     View PubMed
260. Chen GH, Leng S, Mistretta CA. A novel extension of the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections. Med Phys. 2005 Mar; 32(3):654-65.
     View PubMed
261. Zhuang T, Leng S, Nett BE, Chen GH. Fan-beam and cone-beam image reconstruction via filtering the backprojection image of differentiated projection data. Phys Med Biol. 2004 Dec 21; 49(24):5489-503.
     View PubMed
262. Leng S, Zhang L, Chen A, Zhao A. Iterative algorithms applied in research of tomography image reconstruction with incomplete projection data. Nuclear Electronics and Detection Technology [in Chinese] 2003.
     
263. Leng S, Zhang L, Chen Z, Sun S. Fast defect localization in CT Images. Chinese Journal of Stereology and Image Analysis [in Chinese] 2003; 8.