Publications

  1. Edwards JN, Whitney MA, Smith BB, Fah MK, Buckner Petty SA, Durra O, Sell-Dottin KA, Portner E, Wittwer ED, Milam AJ. The role of methadone in cardiac surgery for management of postoperative pain. BJA Open. 2024 Jun; 10:100270 Epub 2024 Mar 22
    View PubMed
  2. Abdelrehim AA, Stephens EH, Pochettino A, Wittwer ED, Ashikhmina EA, Todd AL, Daly RC, Crestanello JA, Schaff HV, Dearani JA. Delayed Sternal Closure vs Emergency Sternal Reopening in Adults with Congenital Heart Disease. Ann Thorac Surg. 2024 May 17 [Epub ahead of print]
    View PubMed
  3. Khandekar DA, Seelhammer TG, Mara KC, Stephens EH, Wittwer ED, Wieruszewski PM. Intraoperative Versus Postoperative Hydroxocobalamin for Vasoplegic Shock in Cardiothoracic Surgery. J Cardiothorac Vasc Anesth. 2023 Dec; 37 (12):2538-2545 Epub 2023 Aug 25
    View PubMed
  4. Radosevich MA, Wieruszewski PM, Wittwer ED. Tris-Hydroxymethyl Aminomethane in Critically Ill Adults: A Systematic Review. Anesth Analg. 2023 Nov 1; 137 (5):1007-1018 Epub 2023 Apr 19
    View PubMed
  5. Brokmeier HM, Seelhammer TG, Nei SD, Gerberi DJ, Mara KC, Wittwer ED, Wieruszewski PM. Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue. J Cardiothorac Vasc Anesth. 2023 Sep; 37(9):1757-1772. Epub 2023 Apr 07.
    View PubMed
  6. Eisenbraun A, Schroeder D, Schaff HV, Martin E, Wittwer ED. Single-Center Retrospective Comparison of Opioid-Based and Multimodal Analgesic Regimens in Adult Cardiac Surgery. J Cardiothorac Vasc Anesth. 2023 Jul; 37 (7):1179-1187 Epub 2023 Mar 10
    View PubMed
  7. Wittwer ED, Cerhan JH, Schroeder DR, Schaff HV, Mauermann WJ. Impact of ketamine versus propofol for anesthetic induction on cognitive dysfunction, delirium, and acute kidney injury following cardiac surgery in elderly, high-risk patients. Ann Card Anaesth. 2023 Jul-Sep; 26 (3):274-280
    View PubMed
  8. Jahanian S, Arghami A, Wittwer ED, King KS, Daly RC, Dearani JA, Rowse PG, Crestanello JA, Schaff HV. Does Minimally Invasive Mitral Valve Repair Mean Less Postoperative Pain? Ann Thorac Surg. 2023 May; 115 (5):1172-1178 Epub 2022 Nov 15
    View PubMed
  9. Wieruszewski PM, Seelhammer TG, Barreto EF, Busse LW, Chow JH, Davison DL, Gaglani B, Khanna AK, Ten Lohuis CC, Mara KC, Wittwer ED. Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support. J Intensive Care Med. 2023 May; 38(5):464-471. Epub 2022 Dec 15.
    View PubMed
  10. Vollmer NJ, Wittwer ED, Rosenbaum AN, Wieruszewski PM. Procainamide pharmacokinetics during extracorporeal membrane oxygenation. Perfusion. 2023 Mar; 38 (2):409-413 Epub 2021 Oct 07
    View PubMed
  11. Wieruszewski PM, Macielak SA, Nei SD, Moman RN, Seelhammer TG, Nabzdyk CGS, Gerberi DJ, Mara KC, Hooten WM, Wittwer ED. Heparin Versus Bivalirudin for Anticoagulation in Adult Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis. ASAIO J. 2023 Feb 01; 69(2):137-144. Epub 2022 Nov 09.
    View PubMed
  12. Seelhammer T, Kressin K, Borhart E, Schroeder D, Amsbaugh A, Steege J, DuBois E, Wittwer E. Buffered Lidocaine as an Endotracheal Tube Cuff Media In Immediate Postoperative Cardiac Surgery Patients And Its Effect On Sedation Requirements: A Prospective Feasibility Study. AANA J. 2023 Feb; 91 (1):7-13
    View PubMed
  13. Vollmer N, Wieruszewski PM, Martin N, Seelhammer T, Wittwer E, Nabzdyk C, Mara K, Nei SD. Predicting the Response of Hydroxocobalamin in Postoperative Vasoplegia in Recipients of Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2022 Aug; 36 (8 Pt B):2908-2916 Epub 2022 Jan 20
    View PubMed
  14. Seelhammer TG, Loftsgard TO, Wittwer ED, Ritter MJ. Cardiac tamponade in a patient supported by veno-arterial extracorporeal membrane oxygenation. Ann Card Anaesth. 2022 Apr-Jun; 25 (2):204-205
    View PubMed
  15. Chow JH, Wittwer ED, Wieruszewski PM, Khanna AK. Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients. J Thorac Cardiovasc Surg 2022 Apr; 163 (4):1407-1414 Epub 2021 Mar 19
    View PubMed
  16. Wieruszewski PM, Wittwer ED, Leung SB, Leung JG. Comment on: Treatment strategies for clozapine-induced hypotension: A systematic review. Ther Adv Psychopharmacol. 2022; 12:20451253221111682 Epub 2022 July 19
    View PubMed
  17. Osborne JC 2nd, Brown CS, Peffley ND, Wittwer ED, Yalamuri SM. Phenytoin Pharmacokinetics During Venoarterial Extracorporeal Membrane Oxygenation and Plasma Exchange. Cureus. 2021 Aug; 13 (8):e17120 Epub 2021 Aug 12
    View PubMed
  18. Boswell MR, Moman RN, Burtoft M, Gerdes H, Martinez J, Gerberi DJ, Wittwer E, Murad MH, Hooten WM. Lidocaine for postoperative pain after cardiac surgery: a systematic review. J Cardiothorac Surg. 2021 May 31; 16(1):157.
    View PubMed
  19. Peffley ND, Pepper MB, Wittwer ED, Dearani JA. Aberrant right subclavian artery and arterioesophageal fistula. Can J Anaesth. 2021 Apr; 68 (4):579-580 Epub 2020 Nov 10
    View PubMed
  20. Seelhammer TG, Plack D, Nei S, Wittwer E, Nelson J, Nabzdyk CGS. Extended duration infusion of high-dose hydroxocobalamin for vasoplegic syndrome following cardiac surgery. Heart Lung. 2021 Mar-Apr; 50 (2):173-176 Epub 2020 Nov 24
    View PubMed
  21. Wieruszewski PM, Wittwer ED, Kashani KB, Brown DR, Butler SO, Clark AM, Cooper CJ, Davison DL, Gajic O, Gunnerson KJ, Tendler R, Mara KC, Barreto EF. Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use. Chest. 2021 Feb; 159 (2):596-605 Epub 2020 Aug 31
    View PubMed
  22. Manento MN, Wittwer ED, Gali B. Individualizing Care for a Vulnerable Population: A Look at the AHA Scientific Statement on Older Adults in the Cardiac Intensive Care Unit. J Cardiothorac Vasc Anesth 2021 Feb; 35 (2):363-365 Epub 2020 Aug 20
    View PubMed
  23. Burtoft MA, Gillespie SM, Laporta ML, Wittwer ED, Schroeder DR, Sprung J, Weingarten TN. Postoperative Nausea and Vomiting and Pain After Robotic-Assisted Mitral Valve Repair. J Cardiothorac Vasc Anesth. 2020 Dec; 34(12):3225-3230. Epub 2020 Jul 09.
    View PubMed
  24. Wieruszewski PM, Nelson S, Wittwer ED, Leung JG. Vasopressor-Refractory Shock From Clozapine Overdose Treated With Synthetic Angiotensin II Infusion. Crit Care Explor. 2020 Sep; 2 (9):e0185 Epub 2020 Sept 14
    View PubMed
  25. Skoff MS, Wittwer ED, Fox JF. Predicting the Future--And Then? Estimating the Length of Stay in the Cardiac Surgical ICU. Journal of Cardiothoracic and Vascular Anesthesia. 2020.
  26. Wittwer ED, Radosevich MA, Ritter M, Cha YM. Stellate Ganglion Blockade for Refractory Ventricular Arrhythmias: Implications of Ultrasound-Guided Technique and Review of the Evidence. J Cardiothorac Vasc Anesth. 2020 Aug; 34 (8):2245-2252 Epub 2019 Dec 13
    View PubMed
  27. Nei SD, Wieruszewski PM, Wittwer ED. Aggressive Antithrombin Supplementation Often Not Necessary During Extracorporeal Membrane Oxygenation. Anesth Analg 2020 May; 130 (5):e153-e154
    View PubMed
  28. Wieruszewski PM, Wittwer ED. Is Dexmedetomidine the Key for Reducing Acute Kidney Injury After Cardiac Surgery? J Cardiothorac Vasc Anesth 2020 Mar; 34 (3):614-615 Epub 2019 Nov 08
    View PubMed
  29. Huang Y, Wittwer ED, Dearani JA, Schaff HV. The impact of surgical incision on hospital stay in patients extubated in the operating room after cardiac surgery. JTCVS Tech. 2020 Mar; 1:62-64 Epub 2020 Jan 21
    View PubMed
  30. D'Souza RS, Gurrieri C, Johnson RL, Warner N, Wittwer E. Intraoperative methadone administration and postoperative pain control: a systematic review and meta-analysis. Pain. 2020 Feb; 161 (2):237-243
    View PubMed
  31. Seelhammer TG, Charnin J, Zhao Y, Wittwer E, Bornhorst J. Elevated Serum Cobalt Concentrations Associated With Hydroxocobalamin Administration for Refractory Vasoplegia. J Cardiothorac Vasc Anesth. 2019 Dec; 33 (12):3402-3405 Epub 2019 Aug 17
    View PubMed
  32. Wieruszewski PM, Radosevich MA, Kashani KB, Daly RC, Wittwer ED. Synthetic Human Angiotensin II for Postcardiopulmonary Bypass Vasoplegic Shock. J Cardiothorac Vasc Anesth. 2019 Nov; 33 (11):3080-3084 Epub 2019 Mar 08
    View PubMed
  33. Zhang P, Liang JJ, Cai C, Tian Y, Dai MY, Wong J, Everett TH 4th, Wittwer ED, Barsness GW, Chen PS, Jiang CY, Cha YM. Characterization of skin sympathetic nerve activity in patients with cardiomyopathy and ventricular arrhythmia. Heart Rhythm. 2019 Nov; 16 (11):1669-1675 Epub 2019 June 13
    View PubMed
  34. Cai C, Dai MY, Tian Y, Zhang P, Wittwer ED, Rho RH, Kapa S, McLeod CJ, Mulpuru SK, Lee HC, Ackerman MJ, Asirvatham SJ, Munger TM, Chen ML, Friedman PA, Cha YM. Electrophysiologic effects and outcomes of sympatholysis in patients with recurrent ventricular arrhythmia and structural heart disease. J Cardiovasc Electrophysiol. 2019 Sep; 30 (9):1499-1507 Epub 2019 July 04
    View PubMed
  35. Tian Y, Wittwer ED, Kapa S, McLeod CJ, Xiao P, Noseworthy PA, Mulpuru SK, Deshmukh AJ, Lee HC, Ackerman MJ, Asirvatham SJ, Munger TM, Liu XP, Friedman PA, Cha YM. Effective Use of Percutaneous Stellate Ganglion Blockade in Patients With Electrical Storm. Circ Arrhythm Electrophysiol. 2019 Sep; 12 (9):e007118 Epub 2019 Sept 13
    View PubMed
  36. Wieruszewski PM, Sims CR, Daly RC, Taner T, Wittwer ED. Use of Angiotensin II for Vasoplegic Shock in a Combined Heart and Liver Transplant Recipient with Systolic Anterior Motion Physiology. J Cardiothorac Vasc Anesth 2019 Aug; 33 (8):2366-2367 Epub 2019 Mar 28
    View PubMed
  37. Armour S, Armour TK, Joppa WR, Maltais S, Nelson JA, Wittwer E. Use of Hydroxocobalamin (Vitamin B12a) in Patients With Vasopressor Refractory Hypotension After Cardiopulmonary Bypass: A Case Series. Anesth Analg. 2019 Jul; 129 (1):e1-e4
    View PubMed
  38. Wieruszewski PM, Nei SD, Maltais S, Schaff HV, Wittwer ED. Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series. A A Pract. 2018 Aug 15; 11 (4):96-99
    View PubMed
  39. Seelhammer TG, Wittwer ED, Nei SD, Skiba J. Maintenance of Drug-Eluting Stent Patency Through Use of a Cangrelor Infusion in the Clinical Setting of Massive Pulmonary Hemorrhage and Venoarterial Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. 2017 Dec; 31 (6):2147-2151 Epub 2017 Mar 24
    View PubMed
  40. Warner MA, Welsby IJ, Norris PJ, Silliman CC, Armour S, Wittwer ED, Santrach PJ, Meade LA, Liedl LM, Nieuwenkamp CM, Douthit B, van Buskirk CM, Schulte PJ, Carter RE, Kor DJ. Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ Open. 2017 Aug 18; 7 (8):e016398
    View PubMed
  41. Cheungpasitporn W, Hui J, Kashani KB, Wittwer ED, Albright RC Jr, Dillon JJ. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun; 10 (3):357-362 Epub 2017 Mar 15
    View PubMed
  42. Renew JR, Wittwer ED, Robb TM, Fritock MD. AngioVac Removal of a Saddle Pulmonary Embolus Using TEE Guidance and Venoarterial ECMO Support. J Cardiothorac Vasc Anesth. 2016 Jun; 30 (3):749-52 Epub 2015 Oct 17
    View PubMed
  43. Guru PK, Bohman JK, Fleming CJ, Tan HL, Sanghavi DK, De Moraes AG, Barsness GW, Wittwer ED, King BF, Arteaga GM, Flick R, Schears GJ. Severe Acute Cardiopulmonary Failure Related to Gadobutrol Magnetic Resonance Imaging Contrast Reaction: Successful Resuscitation With Extracorporeal Membrane Oxygenation. Mayo Clin Proc. 2016 Mar; 91: (3)362-6.
    View PubMed
  44. Wittwer ED, Mauermann WJ, Torres NE, Oderich GS, Pulido JN. Rapid Ventricular Transvenous Pacing via Pulmonary Artery Catheter:Deliberate Hypotension Technique for Precise Proximal Thoracic Aortic Stent Graft Deployment The Open Cardiovascular and Thoracic Surgery Journal. 2015; 8, 2015.
  45. Nei SD, Wittwer ED, Kashani KB, Frazee EN. Levetiracetam Pharmacokinetics in a Patient Receiving Continuous Venovenous Hemofiltration and Venoarterial Extracorporeal Membrane Oxygenation. Pharmacotherapy. 2015 Aug; 35 (8):e127-30 Epub 2015 Aug 03
    View PubMed
  46. Scanlon MM, Gillespie SM, Schaff HV, Cha YM, Wittwer ED. Urgent Ultrasound-Guided Bilateral Stellate Ganglion Blocks in a Patient With Medically Refractory Ventricular Arrhythmias. Crit Care Med. 2015 Aug; 43 (8):e316-8
    View PubMed
  47. Larson KJ, Wittwer ED, Nicholson WT, Weingarten TN, Price DL, Sprung J. Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy. J Clin Anesth. 2015 May; 27: (3)247-51.
    View PubMed
  48. Yeoh TY, Wittwer ED, Weingarten TN, Sprung J. Anesthesia and LEOPARD syndrome: a review of forty-nine anesthetic exposures. J Cardiothorac Vasc Anesth. 2014 Oct; 28: (5)1243-50.
    View PubMed
  49. Wittwer ED, Lynch JJ, Oliver WC Jr, Dearani JA, Burkhart HM, Mauermann WJ. The incidence of vasoplegia in adult patients with right-sided congenital heart defects undergoing cardiac surgery and the correlation with serum vasopressin concentrations. J Thorac Cardiovasc Surg. 2014 Aug; 148 (2):625-30 Epub 2013 Nov 23
    View PubMed
  50. Rehfeldt KH, Wittwer ED, Mauermann WJ. Inferior vena cava obstruction after total artificial heart implantation. Anesth Analg. 2014 Jul; 119 (1):26-29
    View PubMed
  51. Wittwer ED, Pulido JN, Gillespie SM, Cetta F Jr, Dearani JA. Left Main Coronary Artery Compression following Melody Pulmonary Valve Implantation: Use of Impella Support as Rescue Therapy and Perioperative Challenges with ECMO. Case Rep Crit Care. 2014; 2014:959704 Epub 2014 Mar 18
    View PubMed
  52. Wittwer E, Christie A, Fong WK, Gillespie S, Smischney N. Quality initiative to reduce benzodiazepine use in a cardiothoracic intensive care unit. Am J Med. 2014 Jan; 127(1):19-21. Epub 2013 Oct 17
    View PubMed
  53. Beatty NC, Arendt KW, Niesen AD, Wittwer ED, Jacob AK. Analgesia after Cesarean delivery: a retrospective comparison of intrathecal hydromorphone and morphine. J Clin Anesth. 2013 Aug; 25 (5):379-383 Epub 2013 Aug 17
    View PubMed
  54. Wittwer ED, Liu Z, Warner ND, Schroeder DR, Nadeau AM, Allen AR, Murillo CJ, Elvebak RL, Aakre BM, Eisenach JH. beta-1 and beta-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening. Auton Neurosci. 2011 Oct 28; 164 (1-2):89-95 Epub 2011 July 31
    View PubMed
  55. Bohman JK, Wittwer ED, Curry TB, Hartman WR. Kasabach-Merritt syndrome in a patient with Klippel-Trenaunay syndrome undergoing massive transfusion. Internet Journal of Anesthesiology. 2011; 28(1):1. Epub 2011 Mar
  56. Eisenach JH, Wittwer ED. {beta}-Adrenoceptor gene variation and intermediate physiological traits: prediction of distant phenotype. Exp Physiol. 2010 Jul; 95 (7):757-64 Epub 2010 Apr 09
    View PubMed
  57. Wittwer E, Kern SE. Role of morphine's metabolites in analgesia: concepts and controversies. AAPS J. 2006; 8(2):E348-52. Epub 2006 May 26.
    View PubMed
  58. Ratka A, Wittwer ED, Baker L, Kern S. Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Healthy Older Men and Women AJPM. 2004; 14(2):45-53.