Publications

  1. Duch P, Diaz-Valdivia N, Gabasa M, Ikemori R, Arshakyan M, Fernandez-Nogueira P, Llorente A, Teixido C, Ramirez J, Pereda J, Chulia-Peris L, Galbis JM, Hilberg F, Reguart N, Radisky DC, Alcaraz J. Aberrant TIMP-1 production in tumor-associated fibroblasts drives the selective benefits of nintedanib in lung adenocarcinoma. Cancer Sci. 2024 May; 115 (5):1505-1519 Epub 2024 Mar 12
    View PubMed
  2. Rossi M, Radisky DC. Multiplex Digital Spatial Profiling in Breast Cancer Research: State-of-the-Art Technologies and Applications across the Translational Science Spectrum. Cancers (Basel). 2024 Apr 23; 16 (9)
    View PubMed
  3. Sherman ME, Vierkant RA, Winham SJ, Vachon CM, Carter JM, Pacheco-Spann L, Jensen MR, McCauley BM, Hoskin TL, Seymour L, Gehling D, Fischer J, Ghosh K, Radisky DC, Degnim AC. Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era. JAMA Surg 2024 Feb 1; 159 (2):193-201
    View PubMed
  4. Cruz-Reyes N, Radisky DC. Inflammation, Infiltration, and Evasion-Tumor Promotion in the Aging Breast. Cancers (Basel). 2023 Mar 18; 15 (6)
    View PubMed
  5. Sherman ME, Vierkant RA, Masters M, Radisky DC, Winham SJ, Degnim AC, Vachon CM, Patel AV, Teras LR. Benign Breast Disease, NSAIDs, and Postmenopausal Breast Cancer Risk in the CPS-II Cohort. Cancer Prev Res (Phila). 2023 Mar 1; 16 (3):175-184
    View PubMed
  6. Dance YW, Obenreder MC, Seibel AJ, Meshulam T, Ogony JW, Lahiri N, Pacheco-Spann L, Radisky DC, Layne MD, Farmer SR, Nelson CM, Tien J. Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status. Cell Mol Bioeng. 2023 Feb; 16 (1):23-39 Epub 2022 Dec 09
    View PubMed
  7. Ogony J, Hoskin TL, Stallings-Mann M, Winham S, Brahmbhatt R, Arshad MA, Kannan N, Pena A, Allers T, Brown A, Sherman ME, Visscher DW, Knutson KL, Radisky DC, Degnim AC. Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers. Breast Cancer Res Treat. 2023 Jan; 197 (2):277-285 Epub 2022 Nov 16
    View PubMed
  8. Yoseph, Mackenzie, Alex, Tova, Joshua, Nikhil, Laura, Derek, Matthew, Stephen, Celeste. Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status Cellular and Molecular Bioengineering. 2022.
  9. Wickland DP, Sherman ME, Radisky DC, Mansfield AS, Asmann YW. Response to Mitr and Pollack. J Natl Cancer Inst 2022 Dec 8; 114 (12):1729-1730
    View PubMed
  10. Ruddy KJ, Vierkant RA, Jahan N, Higgins A, Partridge A, Larson N, Radisky DC, Couch F, Olson J, Sherman ME. Reproductive risk factors associated with breast cancer in young women by molecular subtype. Breast. 2022 Dec; 66:272-277 Epub 2022 Nov 09
    View PubMed
  11. Liu Y, Bhagwate A, Winham SJ, Stephens MT, Harker BW, McDonough SJ, Stallings-Mann ML, Heinzen EP, Vierkant RA, Hoskin TL, Frost MH, Carter JM, Pfrender ME, Littlepage L, Radisky DC, Cunningham JM, Degnim AC, Wang C. Quality control recommendations for RNASeq using FFPE samples based on pre-sequencing lab metrics and post-sequencing bioinformatics metrics. BMC Med Genomics. 2022 Sep 16; 15 (1):195 Epub 2022 Sept 16
    View PubMed
  12. Wickland DP, Sherman ME, Radisky DC, Mansfield AS, Asmann YW. Lower Exome Sequencing Coverage of Ancestrally African Patients in The Cancer Genome Atlas. J Natl Cancer Inst. 2022 Aug 8; 114 (8):1192-1199
    View PubMed
  13. Duch P, Diaz-Valdivia N, Ikemori R, Gabasa M, Radisky ES, Arshakyan M, Gea-Sorli S, Mateu-Bosch A, Bragado P, Carrasco JL, Mori H, Ramirez J, Teixido C, Reguart N, Fillat C, Radisky DC, Alcaraz J. Aberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma. Matrix Biol. 2022 Aug; 111:207-225 Epub 2022 July 02
    View PubMed
  14. Mehner C, Hockla A, Coban M, Madden B, Estrada R, Radisky DC, Radisky ES. Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. J Biol Chem. 2022 Aug; 298 (8):102146 Epub 2022 June 16
    View PubMed
  15. Ogony J, de Bel T, Radisky DC, Kachergus J, Thompson EA, Degnim AC, Ruddy KJ, Hilton T, Stallings-Mann M, Vachon C, Hoskin TL, Heckman MG, Vierkant RA, White LJ, Moore RM, Carter J, Jensen M, Pacheco-Spann L, Henry JE, Storniolo AM, Winham SJ, van der Laak J, Sherman ME. Towards defining morphologic parameters of normal parous and nulliparous breast tissues by artificial intelligence. Breast Cancer Res. 2022 Jul 11; 24 (1):45 Epub 2022 July 11
    View PubMed
  16. Sherman ME, de Bel T, Heckman MG, White LJ, Ogony J, Stallings-Mann M, Hilton T, Degnim AC, Vierkant RA, Hoskin T, Jensen MR, Pacheco-Spann L, Henry JE, Storniolo AM, Carter JM, Winham SJ, Radisky DC, van der Laak J. Serum hormone levels and normal breast histology among premenopausal women. Breast Cancer Res Treat. 2022 Jul; 194 (1):149-158 Epub 2022 May 03
    View PubMed
  17. Raeeszadeh-Sarmazdeh M, Coban M, Mahajan S, Hockla A, Sankaran B, Downey GP, Radisky DC, Radisky ES. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J Biol Chem. 2022 Mar; 298 (3):101654 Epub 2022 Jan 29
    View PubMed
  18. de Bel T, Litjens G, Ogony J, Stallings-Mann M, Carter JM, Hilton T, Radisky DC, Vierkant RA, Broderick B, Hoskin TL, Winham SJ, Frost MH, Visscher DW, Allers T, Degnim AC, Sherman ME, van der Laak JAWM. Automated quantification of levels of breast terminal duct lobular (TDLU) involution using deep learning. NPJ Breast Cancer. 2022 Jan 19; 8 (1):13
    View PubMed
  19. Winham SJ, Wang C, Heinzen EP, Bhagwate A, Liu Y, McDonough SJ, Stallings-Mann ML, Frost MH, Vierkant RA, Denison LA, Carter JM, Sherman ME, Radisky DC, Degnim AC, Cunningham JM. Somatic mutations in benign breast disease tissues and association with breast cancer risk. BMC Med Genomics. 2021 Jul 14; 14 (1):185 Epub 2021 July 14
    View PubMed
  20. Gabasa M, Radisky ES, Ikemori R, Bertolini G, Arshakyan M, Hockla A, Duch P, Rondinone O, Llorente A, Maqueda M, Davalos A, Gavilan E, Perera A, Ramirez J, Gascon P, Reguart N, Roz L, Radisky DC, Alcaraz J. MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. Cancer Lett. 2021 Jun 1; 507:1-12 Epub 2021 Mar 06
    View PubMed
  21. Jalalirad M, Haddad TC, Salisbury JL, Radisky D, Zhang M, Schroeder M, Tuma A, Leof E, Carter JM, Degnim AC, Boughey JC, Sarkaria J, Yu J, Wang L, Liu MC, Zammataro L, Malatino L, Galanis E, Ingle JN, Goetz MP, D'Assoro AB. Aurora-A kinase oncogenic signaling mediates TGF-beta-induced triple-negative breast cancer plasticity and chemoresistance. Oncogene. 2021 Apr; 40 (14):2509-2523 Epub 2021 Mar 05
    View PubMed
  22. Sequeira GR, Sahores A, Dalotto-Moreno T, Perrotta RM, Pataccini G, Vanzulli SI, Polo ML, Radisky DC, Sartorius CA, Novaro V, Lamb CA, Rabinovich GA, Salatino M, Lanari C. Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity. Cancer Res. 2021 Mar 1; 81 (5):1375-1387 Epub 2020 Dec 02
    View PubMed
  23. Rabie EM, Zhang SX, Kourouklis AP, Kilinc AN, Simi AK, Radisky DC, Tien J, Nelson CM. Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr Biol (Camb). 2021 Feb 3; 13 (1):17-29
    View PubMed
  24. Sherman ME, Vierkant RA, Kaggal S, Hoskin TL, Frost MH, Denison L, Visscher DW, Carter JM, Winham SJ, Jensen MR, Radisky DC, Vachon CM, Degnim AC. Breast Cancer Risk and Use of Nonsteroidal Anti-inflammatory Agents After a Benign Breast Biopsy. Cancer Prev Res (Phila). 2020 Nov; 13 (11):967-976 Epub 2020 July 27
    View PubMed
  25. Ogony JW, Radisky DC, Ruddy KJ, Goodison S, Wickland DP, Egan KM, Knutson KL, Asmann YW, Sherman ME. Immune Responses and Risk of Triple-negative Breast Cancer: Implications for Higher Rates among African American Women. Cancer Prev Res (Phila). 2020 Nov; 13 (11):901-910 Epub 2020 Aug 04
    View PubMed
  26. Mehner C, Miller E, Hockla A, Coban M, Weroha SJ, Radisky DC, Radisky ES. Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma. Oncogene. 2020 Oct; 39(42):6606-6618. Epub 2020 Sep 14.
    View PubMed
  27. Wu X, An Z, Zhao K, Yang S, Lin X, Dai X, Radisky D, Hu J. Integrated strategy combining endobronchial ultrasound with positron emission tomography to diagnose peripheral pulmonary lesions. Thorac Cancer. 2020 Aug; 11 (8):2094-2100 Epub 2020 June 16
    View PubMed
  28. Adhikary S, Hoskin TL, Stallings-Mann ML, Arshad M, Frost MH, Winham SJ, Pena A, Lee DJ, Murphy LM, Rakoff M, Denison LA, Knutson KL, Radisky DC, Visscher DW, Degnim AC. Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease. Breast Cancer Res Treat. 2020 Feb; 180 (1):55-61 Epub 2020 Jan 13
    View PubMed
  29. Goodwin K, Mao S, Guyomar T, Miller E, Radisky DC, Kosmrlj A, Nelson CM. Smooth muscle differentiation shapes domain branches during mouse lung development. Development. 2019 Nov 25; 146 (22)
    View PubMed
  30. Bhagwate AV, Liu Y, Winham SJ, McDonough SJ, Stallings-Mann ML, Heinzen EP, Davila JI, Vierkant RA, Hoskin TL, Frost M, Carter JM, Radisky DC, Cunningham JM, Degnim AC, Wang C. Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples. BMC Genomics. 2019 Sep 2; 20 (1):689 Epub 2019 Sept 02
    View PubMed
  31. Lee HE, Arshad M, Brahmbhatt RD, Hoskin TL, Winham SJ, Frost MH, Radisky DC, Denison LA, Degnim AC, Visscher DW. Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation. Mod Pathol. 2019 Sep; 32 (9):1263-1270 Epub 2019 Apr 17
    View PubMed
  32. Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Warnberg F, Ostman A. Impact of epithelial-stromal interactions on peritumoral fibroblasts in ductal carcinoma in situ JNCI-Journal Of The National Cancer Institute. 2019 Sep; 111 (9):983-95
  33. Raeeszadeh-Sarmazdeh M, Greene KA, Sankaran B, Downey GP, Radisky DC, Radisky ES. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J Biol Chem. 2019 Jun 14; 294 (24):9476-9488 Epub 2019 Apr 30
    View PubMed
  34. Ma H, Hockla A, Mehner C, Coban M, Papo N, Radisky DC, Radisky ES. PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma. Sci Rep. 2019 Feb 12; 9(1):1844.
    View PubMed
  35. Wang Y, Wang E, Zhang Y, Madamsetty VS, Ji B, Radisky DC, Grande JP, Misra S, Mukhopadhyay D. Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension. FASEB J. 2019 Jan; 33 (1):494-500 Epub 2018 Aug 17
    View PubMed
  36. Frank RD, Winham SJ, Vierkant RA, Frost MH, Radisky DC, Ghosh K, Brandt KR, Sherman ME, Visscher DW, Hartmann LC, Degnim AC, Vachon CM. Evaluation of 2 breast cancer risk models in a benign breast disease cohort. Cancer. 2018 Aug; 124 (16):3319-3328 Epub 2018 June 22
    View PubMed
  37. Degnim AC, Winham SJ, Frank RD, Pankratz VS, Dupont WD, Vierkant RA, Frost MH, Hoskin TL, Vachon CM, Ghosh K, Hieken TJ, Carter JM, Denison LA, Broderick B, Hartmann LC, Visscher DW, Radisky DC. Model for Predicting Breast Cancer Risk in Women With Atypical Hyperplasia. J Clin Oncol. 2018 Jun 20; 36 (18):1840-1846 Epub 2018 Apr 20
    View PubMed
  38. Simi AK, Anlas AA, Stallings-Mann M, Zhang S, Hsia T, Cichon M, Radisky DC, Nelson CM. A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail. Cancer Res. 2018 May 1; 78 (9):2277-2289 Epub 2018 Feb 26
    View PubMed
  39. Carter JM, Hoskin TL, Pena MA, Brahmbhatt R, Winham SJ, Frost MH, Stallings-Mann M, Radisky DC, Knutson KL, Visscher DW, Degnim AC. Macrophagic "Crown-like Structures" Are Associated with an Increased Risk of Breast Cancer in Benign Breast Disease. Cancer Prev Res (Phila). 2018 Feb; 11 (2):113-119 Epub 2017 Nov 22
    View PubMed
  40. Kerekes D, Visscher DW, Hoskin TL, Radisky DC, Brahmbhatt RD, Pena A, Frost MH, Arshad M, Stallings-Mann M, Winham SJ, Murphy L, Denison L, Carter JM, Knutson KL, Degnim AC. CD56+ immune cell infiltration and MICA are decreased in breast lobules with fibrocystic changes. Breast Cancer Res Treat. 2018 Feb; 167 (3):649-658 Epub 2017 Nov 01
    View PubMed
  41. von Roemeling CA, Caulfield TR, Marlow L, Bok I, Wen J, Miller JL, Hughes R, Hazlehurst L, Pinkerton AB, Radisky DC, Tun HW, Kim YSB, Lane AL, Copland JA. Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. Oncotarget. 2018 Jan 2; 9 (1):3-20 Epub 2017 Oct 06
    View PubMed
  42. Ghosh K, Vierkant RA, Frank RD, Winham S, Visscher DW, Pankratz VS, Scott CG, Brandt K, Sherman ME, Radisky DC, Frost MH, Hartmann LC, Degnim AC, Vachon CM. Association between mammographic breast density and histologic features of benign breast disease. Breast Cancer Res. 2017 Dec 19; 19 (1):134
    View PubMed
  43. Nelson CM, Gleghorn JP, Pang MF, Jaslove JM, Goodwin K, Varner VD, Miller E, Radisky DC, Stone HA. Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development. Development. 2017 Dec 1; 144 (23):4328-4335 Epub 2017 Oct 30
    View PubMed
  44. Itoh M, Radisky DC, Hashiguchi M, Sugimoto H. The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells. Oncotarget. 2017 Nov 3; 8 (54):92157-92170 Epub 2017 Sept 18
    View PubMed
  45. Winham SJ, Mehner C, Heinzen EP, Broderick BT, Stallings-Mann M, Nassar A, Vierkant RA, Hoskin TL, Frank RD, Wang C, Denison LA, Vachon CM, Frost MH, Hartmann LC, Aubrey Thompson E, Sherman ME, Visscher DW, Degnim AC, Radisky DC. NanoString-based breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Res Treat. 2017 Nov; 166 (2):641-650 Epub 2017 Aug 10
    View PubMed
  46. Radisky ES, Raeeszadeh-Sarmazdeh M, Radisky DC. Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer. J Cell Biochem. 2017 Nov; 118 (11):3531-3548 Epub 2017 July 17
    View PubMed
  47. Stallings-Mann ML, Heinzen EP, Vierkant RA, Winham SJ, Hoskin TL, Denison LA, Nassar A, Hartmann LC, Visscher DW, Frost MH, Sherman ME, Degnim AC, Radisky DC. Postlactational involution biomarkers plasminogen and phospho-STAT3 are linked with active age-related lobular involution. Breast Cancer Res Treat. 2017 Nov; 166 (1):133-143 Epub 2017 July 27
    View PubMed
  48. Visscher DW, Frank RD, Carter JM, Vierkant RA, Winham SJ, Heinzen EP, Broderick BT, Denison LA, Allers TM, Johnson JL, Frost MH, Hartmann LC, Degnim AC, Radisky DC. Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies. J Natl Cancer Inst. 2017 Oct 01; 109(10).
    View PubMed
  49. Degnim AC, Hoskin TL, Arshad M, Frost MH, Winham SJ, Brahmbhatt RA, Pena A, Carter JM, Stallings-Mann ML, Murphy LM, Miller EE, Denison LA, Vachon CM, Knutson KL, Radisky DC, Visscher DW. Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development. Clin Cancer Res. 2017 Jul 15; 23 (14):3945-3952 Epub 2017 Jan 26
    View PubMed
  50. Santen RJ, Radisky DC, Degnim A, Frost MH, Vachon CM, Ghosh K, Guestini F, McNamara KM, Sasano H. Aromatase expression in atypical ductal hyperplasia in women. Breast Cancer Res Treat. 2017 Jun; 163 (3):623-629 Epub 2017 Mar 23
    View PubMed
  51. Mehner C, Oberg AL, Goergen KM, Kalli KR, Maurer MJ, Nassar A, Goode EL, Keeney GL, Jatoi A, Radisky DC, Radisky ES. EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review. Genes Cancer. 2017 May; 8 (5-6):589-599
    View PubMed
  52. Vierkant RA, Degnim AC, Radisky DC, Visscher DW, Heinzen EP, Frank RD, Winham SJ, Frost MH, Scott CG, Jensen MR, Ghosh K, Manduca A, Brandt KR, Whaley DH, Hartmann LC, Vachon CM. Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort. BMC Cancer. 2017 Jan 31; 17 (1):84
    View PubMed
  53. Mullooly M, Yang HP, Falk RT, Nyante SJ, Cora R, Pfeiffer RM, Radisky DC, Visscher DW, Hartmann LC, Carter JM, Degnim AC, Stanczyk FZ, Figueroa JD, Garcia-Closas M, Lissowska J, Troester MA, Hewitt SM, Brinton LA, Sherman ME, Gierach GL. Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients. Breast Cancer Res. 2017 Jan 19; 19 (1):8
    View PubMed
  54. Degnim AC, Dupont WD, Radisky DC, Vierkant RA, Frank RD, Frost MH, Winham SJ, Sanders ME, Smith JR, Page DL, Hoskin TL, Vachon CM, Ghosh K, Hieken TJ, Denison LA, Carter JM, Hartmann LC, Visscher DW. Extent of atypical hyperplasia stratifies breast cancer risk in 2 independent cohorts of women. Cancer. 2016 Oct; 122 (19):2971-8 Epub 2016 June 28
    View PubMed
  55. Pang MF, Siedlik MJ, Han S, Stallings-Mann M, Radisky DC, Nelson CM. Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells. Cancer Res. 2016 Sep 15; 76 (18):5277-87 Epub 2016 Aug 08
    View PubMed
  56. Hieken TJ, Chen J, Hoskin TL, Walther-Antonio M, Johnson S, Ramaker S, Xiao J, Radisky DC, Knutson KL, Kalari KR, Yao JZ, Baddour LM, Chia N, Degnim AC. The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease. Sci Rep. 2016 Aug 3; 6:30751 Epub 2016 Aug 03
    View PubMed
  57. Figueroa JD, Pfeiffer RM, Brinton LA, Palakal MM, Degnim AC, Radisky D, Hartmann LC, Frost MH, Stallings Mann ML, Papathomas D, Gierach GL, Hewitt SM, Duggan MA, Visscher D, Sherman ME. Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study. Breast Cancer Res Treat. 2016 Aug; 159 (1):163-72 Epub 2016 Aug 03
    View PubMed
  58. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cancer Res. 2016 Jun 15; 76 (12):3520-30 Epub 2016 Apr 13
    View PubMed
  59. Yushi Q, Li Z, Von Roemeling CA, Doeppler H, Marlow LA, Kim BY, Radisky DC, Storz P, Copland JA, Tun HW. Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma. Oncotarget. 2016 May 31; 7 (22):32156-71
    View PubMed
  60. Cohen I, Kayode O, Hockla A, Sankaran B, Radisky DC, Radisky ES, Papo N. Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy. Biochem J. 2016 May 15; 473 (10):1329-41 Epub 2016 Mar 08
    View PubMed
  61. Liu Y, Zhao Y, Skerry B, Wang X, Colin-Cassin C, Radisky DC, Kaestner KH, Li Z. Foxa1 is essential for mammary duct formation. Genesis. 2016 May; 54 (5):277-85 Epub 2016 Mar 29
    View PubMed
  62. Radisky DC, Visscher DW, Frank RD, Vierkant RA, Winham S, Stallings-Mann M, Hoskin TL, Nassar A, Vachon CM, Denison LA, Hartmann LC, Frost MH, Degnim AC. Natural history of age-related lobular involution and impact on breast cancer risk. Breast Cancer Res Treat. 2016 Feb; 155 (3):423-30 Epub 2016 Feb 04
    View PubMed
  63. Visscher DW, Frost MH, Hartmann LC, Frank RD, Vierkant RA, McCullough AE, Winham SJ, Vachon CM, Ghosh K, Brandt KR, Farrell AM, Tarabishy Y, Hieken TJ, Haddad TC, Kraft RA, Radisky DC, Degnim AC. Clinicopathologic features of breast cancers that develop in women with previous benign breast disease. Cancer. 2016 Feb 1; 122 (3):378-85 Epub 2015 Oct 29
    View PubMed
  64. Mehner C, Oberg AL, Kalli KR, Nassar A, Hockla A, Pendlebury D, Cichon MA, Goergen KM, Maurer MJ, Goode EL, Keeney GL, Jatoi A, Sahin-Toth M, Copland JA, Radisky DC, Radisky ES. Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers. Oncotarget. 2015 Nov 3; 6 (34):35737-54
    View PubMed
  65. Mehner C, Miller E, Nassar A, Bamlet WR, Radisky ES, Radisky DC. Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma. Genes Cancer. 2015 Nov; 6 (11-12):480-9
    View PubMed
  66. Hieken TJ, Carter JM, Hawse JR, Hoskin TL, Bois M, Frost M, Hartmann LC, Radisky DC, Visscher DW, Degnim AC. ERbeta expression and breast cancer risk prediction for women with atypias. Cancer Prev Res (Phila). 2015 Nov; 8 (11):1084-92 Epub 2015 Aug 14
    View PubMed
  67. Kim HY, Pang MF, Varner VD, Kojima L, Miller E, Radisky DC, Nelson CM. Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung. Dev Cell. 2015 Sep 28; 34 (6):719-26 Epub 2015 Sept 18
    View PubMed
  68. Polo ML, Riggio M, May M, Rodriguez MJ, Perrone MC, Stallings-Mann M, Kaen D, Frost M, Goetz M, Boughey J, Lanari C, Radisky D, Novaro V. Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression. Oncotarget. 2015 Sep 8; 6 (26):22081-97
    View PubMed
  69. Nassar A, Visscher DW, Degnim AC, Frank RD, Vierkant RA, Frost M, Radisky DC, Vachon CM, Kraft RA, Hartmann LC, Ghosh K. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study. Breast Cancer Res Treat. 2015 Sep; 153 (2):397-405 Epub 2015 Aug 12
    View PubMed
  70. Degnim AC, Nassar A, Stallings-Mann M, Keith Anderson S, Oberg AL, Vierkant RA, Frank RD, Wang C, Winham SJ, Frost MH, Hartmann LC, Visscher DW, Radisky DC. Gene signature model for breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Res Treat. 2015 Aug; 152 (3):687-94 Epub 2015 July 23
    View PubMed
  71. Varner VD, Gleghorn JP, Miller E, Radisky DC, Nelson CM. Mechanically patterning the embryonic airway epithelium. Proc Natl Acad Sci U S A. 2015 Jul 28; 112 (30):9230-5 Epub 2015 July 13
    View PubMed
  72. Borges S, Perez EA, Thompson EA, Radisky DC, Geiger XJ, Storz P. Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101. Mol Cancer Ther. 2015 Jun; 14 (6):1306-16 Epub 2015 Apr 07
    View PubMed
  73. Radisky ES, Radisky DC. Matrix metalloproteinases as breast cancer drivers and therapeutic targets. Front Biosci (Landmark Ed). 2015 Jun 1; 20 (7):1144-63 Epub 2015 June 01
    View PubMed
  74. Said SM, Visscher DW, Nassar A, Frank RD, Vierkant RA, Frost MH, Ghosh K, Radisky DC, Hartmann LC, Degnim AC. Flat epithelial atypia and risk of breast cancer: A Mayo cohort study. Cancer. 2015 May 15; 121 (10):1548-55 Epub 2015 Jan 13
    View PubMed
  75. Nassar A, Hoskin TL, Stallings-Mann ML, Degnim AC, Radisky DC, Frost MH, Vierkant RA, Hartmann LC, Visscher DW. Ki-67 expression in sclerosing adenosis and adjacent normal breast terminal ductal lobular units: a nested case-control study from the Mayo Benign Breast Disease Cohort. Breast Cancer Res Treat. 2015 May; 151 (1):89-97 Epub 2015 Apr 12
    View PubMed
  76. Pankratz VS, Degnim AC, Frank RD, Frost MH, Visscher DW, Vierkant RA, Hieken TJ, Ghosh K, Tarabishy Y, Vachon CM, Radisky DC, Hartmann LC. Model for individualized prediction of breast cancer risk after a benign breast biopsy. J Clin Oncol. 2015 Mar 10; 33 (8):923-9 Epub 2015 Jan 26
    View PubMed
  77. Liou GY, Doppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015 Feb 20; 6:6200
    View PubMed
  78. Cichon MA, Nelson CM, Radisky DC. Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion. Cancer Inform. 2015; 14 (Suppl 3):1-13 Epub 2015 Feb 09
    View PubMed
  79. Boghaert E, Radisky DC, Nelson CM. Lattice-based model of ductal carcinoma in situ suggests rules for breast cancer progression to an invasive state. PLoS Comput Biol. 2014 Dec; 10 (12):e1003997 Epub 2014 Dec 04
    View PubMed
  80. Bria E, Di Modugno F, Sperduti I, Iapicca P, Visca P, Alessandrini G, Antoniani B, Pilotto S, Ludovini V, Vannucci J, Bellezza G, Sidoni A, Tortora G, Radisky DC, Crino L, Cognetti F, Facciolo F, Mottolese M, Milella M, Nistico P. Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer. Oncotarget. 2014 Nov 30; 5 (22):11054-63
    View PubMed
  81. Mitro SD, Ali-Fehmi R, Bandyopadhyay S, Alosh B, Albashiti B, Radisky DC, Frost MH, Degnim AC, Ruterbusch JJ, Cote ML. Clinical characteristics of breast cancers in African-American women with benign breast disease: a comparison to the surveillance, epidemiology, and end results program. Breast J. 2014 Nov; 20(6):571-7.
    View PubMed
  82. Mehner C, Miller E, Khauv D, Nassar A, Oberg AL, Bamlet WR, Zhang L, Waldmann J, Radisky ES, Crawford HC, Radisky DC. Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Mol Cancer Res. 2014 Oct; 12 (10):1430-9 Epub 2014 May 21
    View PubMed
  83. Miura Y, Hagiwara N, Radisky DC, Hirai Y. CCAAT/enhancer binding protein beta (C/EBPbeta) isoform balance as a regulator of epithelial-mesenchymal transition in mouse mammary epithelial cells. Exp Cell Res. 2014 Sep 10; 327(1):146-55. Epub 2014 May 29.
    View PubMed
  84. Cichon MA, Radisky DC. Cutting the brakes and flooring the gas: how TMEPAI turns TGF-beta into a tumor promoter. Genes Cancer. 2014 Sep; 5 (9-10):303-5
    View PubMed
  85. von Roemeling CA, Radisky DC, Marlow LA, Cooper SJ, Grebe SK, Anastasiadis PZ, Tun HW, Copland JA. Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. Cancer Res. 2014 Sep 1; 74 (17):4796-810 Epub 2014 June 24
    View PubMed
  86. Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, Sasinowska H, Zhu H, Drake R, Sasinowski M, Tun HW, Copland JA. Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Oncotarget. 2014 Jul 30; 5 (14):5320-34
    View PubMed
  87. Mehner C, Hockla A, Miller E, Ran S, Radisky DC, Radisky ES. Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget. 2014 May 15; 5 (9):2736-49
    View PubMed
  88. Cichon MA, Radisky DC. ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail. Oncotarget. 2014 May 15; 5 (9):2827-38
    View PubMed
  89. Degnim AC, Brahmbhatt RD, Radisky DC, Hoskin TL, Stallings-Mann M, Laudenschlager M, Mansfield A, Frost MH, Murphy L, Knutson K, Visscher DW. Immune cell quantitation in normal breast tissue lobules with and without lobulitis. Breast Cancer Res Treat. 2014 Apr; 144 (3):539-49 Epub 2014 Mar 05
    View PubMed
  90. Asiedu MK, Beauchamp-Perez FD, Ingle JN, Behrens MD, Radisky DC, Knutson KL. AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells. Oncogene. 2014 Mar 6; 33 (10):1316-24 Epub 2013 Mar 11
    View PubMed
  91. Hartmann LC, Radisky DC, Frost MH, Santen RJ, Vierkant RA, Benetti LL, Tarabishy Y, Ghosh K, Visscher DW, Degnim AC. Understanding the premalignant potential of atypical hyperplasia through its natural history: a longitudinal cohort study. Cancer Prev Res (Phila). 2014 Feb; 7 (2):211-7 Epub 2014 Jan 30
    View PubMed
  92. Visscher DW, Nassar A, Degnim AC, Frost MH, Vierkant RA, Frank RD, Tarabishy Y, Radisky DC, Hartmann LC. Sclerosing adenosis and risk of breast cancer. Breast Cancer Res Treat. 2014 Feb; 144 (1):205-12 Epub 2014 Feb 08
    View PubMed
  93. Cichon MA, Radisky DC. Extracellular matrix as a contextual determinant of transforming growth factor-beta signaling in epithelial-mesenchymal transition and in cancer. Cell Adh Migr. 2014; 8 (6):588-94
    View PubMed
  94. Yamashita CM, Radisky DC, Aschner Y, Downey GP. The importance of matrix metalloproteinase-3 in respiratory disorders. Expert Rev Respir Med. 2014; 8:411-21.
    View PubMed
  95. Chen QK, Lee K, Radisky DC, Nelson CM. Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation. 2013 Oct; 86(3):126-32. Epub 2013 May 06.
    View PubMed
  96. Bascom JL, Radisky DC, Koh E, Fata JE, Lo A, Mori H, Roosta N, Hirai Y, Bissell MJ. Epimorphin is a novel regulator of the progesterone receptor isoform-a. Cancer Res. 2013 Sep 15; 73 (18):5719-29 Epub 2013 July 18
    View PubMed
  97. Mehner C, Radisky DC. Triggering the landslide: The tumor-promotional effects of myofibroblasts. Exp Cell Res. 2013 Jul 1; 319 (11):1657-62 Epub 2013 Mar 22
    View PubMed
  98. Kalari KR, Necela BM, Tang X, Thompson KJ, Lau M, Eckel-Passow JE, Kachergus JM, Anderson SK, Sun Z, Baheti S, Carr JM, Baker TR, Barman P, Radisky DC, Joseph RW, McLaughlin SA, Chai HS, Camille S, Rossell D, Asmann YW, Thompson EA, Perez EA. An integrated model of the transcriptome of HER2-positive breast cancer. PLoS One. 2013; 8 (11):e79298 Epub 2013 Nov 01
    View PubMed
  99. Cote ML, Ruterbusch JJ, Alosh B, Bandyopadhyay S, Kim E, Albashiti B, Sharaf Aldeen B, Radisky DC, Frost MH, Visscher DW, Hartmann LC, Nassar WH, Ali-Femhi R. Benign breast disease and the risk of subsequent breast cancer in African American women. Cancer Prev Res (Phila). 2012 Dec; 5(12):1375-80. Epub 2012 Oct 19
    View PubMed
  100. Hockla A, Miller E, Salameh MA, Copland JA, Radisky DC, Radisky ES. PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer. Mol Cancer Res. 2012 Dec; 10 (12):1555-66
    View PubMed
  101. Boghaert E, Gleghorn JP, Lee K, Gjorevski N, Radisky DC, Nelson CM. Host epithelial geometry regulates breast cancer cell invasiveness. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19632-7. Epub 2012 Nov 12.
    View PubMed
  102. Lee K, Chen QK, Lui C, Cichon MA, Radisky DC, Nelson CM. Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol Biol Cell. 2012 Oct; 23(20):4097-108. Epub 2012 Aug 23.
    View PubMed
  103. Radisky D. On the role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol. 2012 Sep 1; 4 (9):a013458 Epub 2012 Sept 01
    View PubMed
  104. Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med. 2012 Jul 11; 4 (142):142ra95
    View PubMed
  105. Pelisch F, Khauv D, Risso G, Stallings-Mann M, Blaustein M, Quadrana L, Radisky DC, Srebrow A. Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. J Cell Biochem. 2012 Jul; 113(7):2319-29.
    View PubMed
  106. Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell MJ, Bishop JM. MYC suppresses cancer metastasis by direct transcriptional silencing of alphav and beta3 integrin subunits. Nat Cell Biol. 2012 Jun; 14(6):567-74. Epub 2012 May 13.
    View PubMed
  107. Batra J, Robinson J, Soares AS, Fields AP, Radisky DC, Radisky ES. Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. J Biol Chem. 2012 May 4; 287 (19):15935-46 Epub 2012 Mar 16
    View PubMed
  108. Degnim AC, Visscher DW, Hoskin TL, Frost MH, Vierkant RA, Vachon CM, Shane Pankratz V, Radisky DC, Hartmann LC. Histologic findings in normal breast tissues: comparison to reduction mammaplasty and benign breast disease tissues. Breast Cancer Res Treat. 2012 May; 133 (1):169-77 Epub 2011 Sept 01
    View PubMed
  109. Asmann YW, Necela BM, Kalari KR, Hossain A, Baker TR, Carr JM, Davis C, Getz JE, Hostetter G, Li X, McLaughlin SA, Radisky DC, Schroth GP, Cunliffe HE, Perez EA, Thompson EA. Detection of redundant fusion transcripts as biomarkers or disease-specific therapeutic targets in breast cancer. Cancer Res. 2012 Apr 15; 72(8):1921-8. Epub 2012 Apr 10.
    View PubMed
  110. Cichon MA, Gainullin VG, Zhang Y, Radisky DC. Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy. Integr Biol (Camb). 2012 Apr; 4 (4):440-8 Epub 2011 Nov 17
    View PubMed
  111. Nistico P, Bissell MJ, Radisky DC. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol. 2012 Feb; 4(2). Epub 2012 Feb 01.
    View PubMed
  112. Batra J, Robinson J, Mehner C, Hockla A, Miller E, Radisky DC, Radisky ES. PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1). PLoS One. 2012; 7 (11):e50028 Epub 2012 Nov 20
    View PubMed
  113. Ghosh K, Brandt KR, Reynolds C, Scott CG, Pankratz VS, Riehle DL, Lingle WL, Odogwu T, Radisky DC, Visscher DW, Ingle JN, Hartmann LC, Vachon CM. Tissue composition of mammographically dense and non-dense breast tissue. Breast Cancer Res Treat. 2012 Jan; 131 (1):267-75 Epub 2011 Aug 30
    View PubMed
  114. Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC. p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila). 2011 Dec; 4 (12):1953-60 Epub 2011 Sept 15
    View PubMed
  115. Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem J. 2011 Nov 15; 440 (1):95-105
    View PubMed
  116. Yamashita CM, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, Downey GP. Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol. 2011 Oct; 179(4):1733-45. Epub 2011 Aug 24.
    View PubMed
  117. Asmann YW, Hossain A, Necela BM, Middha S, Kalari KR, Sun Z, Chai HS, Williamson DW, Radisky D, Schroth GP, Kocher JP, Perez EA, Thompson EA. A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines. Nucleic Acids Res. 2011 Aug; 39 (15):e100 Epub 2011 May 27
    View PubMed
  118. Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM. Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. EMBO J. 2011 Jul 6; 30(13):2662-74. Epub 2011 May 24.
    View PubMed
  119. Asiedu MK, Ingle JN, Behrens MD, Radisky DC, Knutson KL. TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res. 2011 Jul 1; 71 (13):4707-19 Epub 2011 May 09
    View PubMed
  120. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22.
    View PubMed
  121. Cichon MA, Radisky ES, Radisky DC. Identifying the stroma as a critical player in radiation-induced mammary tumor development. Cancer Cell. 2011 May 17; 19(5):571-2.
    View PubMed
  122. Barr FE, Degnim AC, Hartmann LC, Radisky DC, Boughey JC, Anderson SS, Vierkant RA, Frost MH, Visscher DW, Reynolds C. Estrogen receptor expression in atypical hyperplasia: lack of association with breast cancer. Cancer Prev Res (Phila). 2011 Mar; 4(3):435-44. Epub 2011 Jan 05.
    View PubMed
  123. Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW. Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol. 2010 Dec; 17 (12):3269-77 Epub 2010 June 22
    View PubMed
  124. Cichon MA, Degnim AC, Visscher DW, Radisky DC. Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer. J Mammary Gland Biol Neoplasia. 2010 Dec; 15 (4):389-97 Epub 2010 Dec 16
    View PubMed
  125. Hockla A, Radisky DC, Radisky ES. Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109. Breast Cancer Res Treat. 2010 Nov; 124 (1):27-38 Epub 2009 Dec 25
    View PubMed
  126. Orlichenko L, Geyer R, Yanagisawa M, Khauv D, Radisky ES, Anastasiadis PZ, Radisky DC. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. J Biol Chem. 2010 Jun 18; 285 (25):19153-61 Epub 2010 Apr 15
    View PubMed
  127. Cichon MA, Radisky DC. Separation anxiety: detachment from the extracellular matrix induces metabolic changes that can stimulate tumorigenesis. J Mol Cell Biol. 2010 Jun; 2(3):113-5. Epub 2009 Dec 18.
    View PubMed
  128. Radisky ES, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15 (2):201-12 Epub 2010 May 05
    View PubMed
  129. Cooper SJ, Zou H, Legrand SN, Marlow LA, von Roemeling CA, Radisky DC, Wu KJ, Hempel N, Margulis V, Tun HW, Blobe GC, Wood CG, Copland JA. Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. Oncogene. 2010 May 20; 29 (20):2905-15 Epub 2010 Mar 08
    View PubMed
  130. Ghosh K, Hartmann LC, Reynolds C, Visscher DW, Brandt KR, Vierkant RA, Scott CG, Radisky DC, Sellers TA, Pankratz VS, Vachon CM. Association between mammographic density and age-related lobular involution of the breast. J Clin Oncol. 2010 May 1; 28 (13):2207-12 Epub 2010 Mar 29
    View PubMed
  131. Reiman JM, Knutson KL, Radisky DC. Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells. Cancer Res. 2010 Apr 15; 70 (8):3005-8
    View PubMed
  132. McKian KP, Reynolds CA, Visscher DW, Nassar A, Radisky DC, Vierkant RA, Degnim AC, Boughey JC, Ghosh K, Anderson SS, Minot D, Caudill JL, Vachon CM, Frost MH, Pankratz VS, Hartmann LC. Novel breast tissue feature strongly associated with risk of breast cancer. J Clin Oncol. 2009 Dec 10; 27 (35):5893-8 Epub 2009 Oct 05
    View PubMed
  133. Vierkant RA, Hartmann LC, Pankratz VS, Anderson SS, Radisky D, Frost MH, Vachon CM, Ghosh K, Distad TJ, Degnim AC, Reynolds CA. Lobular involution: localized phenomenon or field effect? Breast Cancer Res Treat. 2009 Sep; 117 (1):193-6 Epub 2008 July 01
    View PubMed
  134. Radisky DC, Hartmann LC. Mammary involution and breast cancer risk: transgenic models and clinical studies. J Mammary Gland Biol Neoplasia. 2009 Jun; 14 (2):181-91 Epub 2009 Apr 30
    View PubMed
  135. Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, Haluska P, Ingle JN, Hartmann LC, Manjili MH, Radisky DC, Ferrone S, Knutson KL. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 2009 Apr 1; 69 (7):2887-95 Epub 2009 Mar 10
    View PubMed
  136. Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem. 2009 Mar 13; 284(11):6877-84. Epub 2009 Jan 07.
    View PubMed
  137. Radisky DC, Stallings-Mann M, Hirai Y, Bissell MJ. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol. 2009 Mar; 10 (3):228-34 Epub 2009 Feb 04
    View PubMed
  138. Marlow LA, Reynolds LA, Cleland AS, Cooper SJ, Gumz ML, Kurakata S, Fujiwara K, Zhang Y, Sebo T, Grant C, McIver B, Wadsworth JT, Radisky DC, Smallridge RC, Copland JA. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15; 69 (4):1536-44 Epub 2009 Feb 10
    View PubMed
  139. Alcaraz J, Xu R, Mori H, Nelson CM, Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C, Bissell MJ. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J. 2008 Nov 5; 27(21):2829-38. Epub 2008 Oct 09.
    View PubMed
  140. Cao Y, Wang L, Nandy D, Zhang Y, Basu A, Radisky D, Mukhopadhyay D. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res. 2008 Nov 1; 68 (21):8667-72
    View PubMed
  141. Nelson CM, Khauv D, Bissell MJ, Radisky DC. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008 Sep 1; 105(1):25-33.
    View PubMed
  142. Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene. 2008 Aug 14; 27 (35):4841-53 Epub 2008 Apr 21
    View PubMed
  143. Turley EA, Veiseh M, Radisky DC, Bissell MJ. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol. 2008 May; 5(5):280-90. Epub 2008 Mar 18.
    View PubMed
  144. Radisky DC, Przybylo JA. Matrix metalloproteinase-induced fibrosis and malignancy in breast and lung. Proc Am Thorac Soc. 2008 Apr 15; 5(3):316-22.
    View PubMed
  145. Orlichenko LS, Radisky DC. Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis. 2008; 25 (6):593-600 Epub 2008 Feb 20
    View PubMed
  146. Radisky ES, Radisky DC. Stromal induction of breast cancer: inflammation and invasion. Rev Endocr Metab Disord. 2007 Sep; 8 (3):279-87
    View PubMed
  147. Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem. 2007 Jul 1; 101 (4):830-9
    View PubMed
  148. Hirai Y, Nelson CM, Yamazaki K, Takebe K, Przybylo J, Madden B, Radisky DC. Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis. J Cell Sci. 2007 Jun 15; 120(Pt 12):2032-43. Epub 2007 May 29.
    View PubMed
  149. Stallings-Mann M, Radisky D. Matrix metalloproteinase-induced malignancy in mammary epithelial cells. Cells Tissues Organs. 2007; 185(1-3):104-10.
    View PubMed
  150. Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace. Int J Biochem Cell Biol. 2007; 39 (6):1082-8 Epub 2007 Mar 12
    View PubMed
  151. Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4134-9. Epub 2006 Mar 07.
    View PubMed
  152. Radisky DC, Bissell MJ. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev. 2006 Feb; 16 (1):45-50 Epub 2005 Dec 27
    View PubMed
  153. Radisky DC. Epithelial-mesenchymal transition. J Cell Sci. 2005 Oct 1; 118(Pt 19):4325-6.
    View PubMed
  154. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005 Jul 7; 436(7047):123-7.
    View PubMed
  155. Liu H, Radisky DC, Bissell MJ. Proliferation and polarity in breast cancer: untying the Gordian knot. Cell Cycle. 2005 May; 4(5):646-9. Epub 2005 May 09.
    View PubMed
  156. Bissell MJ, Kenny PA, Radisky DC. Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol. 2005; 70:343-56.
    View PubMed
  157. Liu H, Radisky DC, Wang F, Bissell MJ. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol. 2004 Feb 16; 164(4):603-12. Epub 2004 Feb 09.
    View PubMed
  158. Novaro V, Radisky DC, Ramos Castro NE, Weisz A, Bissell MJ. Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Clin Cancer Res. 2004 Jan 1; 10(1 Pt 2):402S-9S.
    View PubMed
  159. Takebe K, Oka Y, Radisky D, Tsuda H, Tochigui K, Koshida S, Kogo K, Hirai Y. Epimorphin acts to induce hair follicle anagen in C57BL/6 mice. FASEB J. 2003 Nov; 17(14):2037-47.
    View PubMed
  160. Radisky DC, Hirai Y, Bissell MJ. Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol. 2003 Aug; 13(8):426-34.
    View PubMed
  161. Tuttle MS, Radisky D, Li L, Kaplan J. A dominant allele of PDR1 alters transition metal resistance in yeast. J Biol Chem. 2003 Jan 10; 278(2):1273-80. Epub 2002 Oct 30.
    View PubMed
  162. Bhattacharyya C, Grate LR, Rizki A, Radisky D, Molina FJ, Jordan MI, Bissell MJ, Mian IS. Simultaneous classification and relevant feature identification in high-dimensional spaces: application to molecular profiling data. Signal Processing. 2003; 83:729-43.
  163. Novaro V, Pustovrh C, Colman-Lerner A, Radisky D, Lo Nostro F, Paz D, Jawerbaum A, Gonzalez E. Nitric oxide induces gelatinase A (matrix metalloproteinase 2) during rat embryo implantation. Fertil Steril. 2002 Dec; 78(6):1278-87.
    View PubMed
  164. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation. 2002 Dec; 70(9-10):537-46.
    View PubMed
  165. Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst. 2002 Oct 2; 94(19):1494-503.
    View PubMed
  166. Novaro V, Radisky D. 93rd Annual Meeting of the American Association for Cancer Research, San Francisco, CA, USA, 6-10 April 2002. Breast Cancer Res. 2002; 4(4):165-8. Epub 2002 May 10.
    View PubMed
  167. Radisky D, Muschler J, Bissell MJ. Order and disorder: the role of extracellular matrix in epithelial cancer. Cancer Invest. 2002; 20(1):139-53.
    View PubMed
  168. Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer. 2001 Oct; 1(1):46-54.
    View PubMed
  169. McVey Ward D, Radisky D, Scullion MA, Tuttle MS, Vaughn M, Kaplan J. hVPS41 is expressed in multiple isoforms and can associate with vesicles through a RING-H2 finger motif. Exp Cell Res. 2001 Jul 1; 267(1):126-34.
    View PubMed
  170. Hirai Y, Radisky D, Boudreau R, Simian M, Stevens ME, Oka Y, Takebe K, Niwa S, Bissell MJ. Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta. J Cell Biol. 2001 May 14; 153(4):785-94.
    View PubMed
  171. Radisky D, Hagios C, Bissell MJ. Tumors are unique organs defined by abnormal signaling and context. Semin Cancer Biol. 2001 Apr; 11(2):87-95.
    View PubMed
  172. Pujuguet P, Radisky D, Levy D, Lacza C, Bissell MJ. Trichostatin A inhibits beta-casein expression in mammary epithelial cells. J Cell Biochem. 2001; 83(4):660-70.
    View PubMed
  173. Moler EJ, Radisky DC, Mian IS. Integrating naive Bayes models and external knowledge to examine copper and iron homeostasis in S. cerevisiae. Physiol Genomics. 2000 Dec 18; 4(2):127-35.
    View PubMed
  174. Radisky D, Kaplan J. Regulation of transition metal transport across the yeast plasma membrane. J Biol Chem. 1999 Feb 19; 274(8):4481-4.
    View PubMed
  175. Radisky DC, Babcock MC, Kaplan J. The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle. J Biol Chem. 1999 Feb 19; 274(8):4497-9.
    View PubMed
  176. Radisky DC, Kaplan J. Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem J. 1998 Nov 15; 336(Pt 1):201-5.
    View PubMed
  177. Davis-Kaplan SR, Askwith CC, Bengtzen AC, Radisky D, Kaplan J. Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13641-5.
    View PubMed
  178. Radisky DC, Snyder WB, Emr SD, Kaplan J. Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5662-6.
    View PubMed
  179. Barrows LR, Radisky DC, Copp BR, Swaffar DS, Kramer RA, Warters RL, Ireland CM. Makaluvamines, marine natural products, are active anti-cancer agents and DNA topo II inhibitors. Anticancer Drug Des. 1993 Oct; 8(5):333-47.
    View PubMed
  180. Radisky DC, Radisky ES, Barrows LR, Copp BR, Kramer RA, Ireland CM. Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya. J Am Chem Soc. 1993; 115:1632-8.