Publications

  1. Ho MF, Zhang C, Cohan JS, Tuncturk M, Heider RM, Coombes BJ, Biernacka J, Moon I, Skime M, Ho AM, Ngo Q, Skillon C, Croarkin PE, Oesterle TS, Karpyak VM, Li H, Weinshilboum RM. IL17RB genetic variants are associated with acamprosate treatment response in patients with alcohol use disorder: A proteomics-informed genomics study. Brain Behav Immun. 2024 Jun 8; 120:304-314 Epub 2024 June 08
    View PubMed
  2. Bormann NL, Oesterle TS, Arndt S, Karpyak VM, Croarkin PE. Systematic review and meta-analysis: Combining transcranial magnetic stimulation or direct current stimulation with pharmacotherapy for treatment of substance use disorders. Am J Addict. 2024 May; 33 (3):269-282 Epub 2024 Jan 25
    View PubMed
  3. Oesterle TS, Hall-Flavin DK, Bormann NL, Loukianova LL, Fipps DC, Breitinger SA, Gilliam WP, Wu T, Correa da Costa S, Arndt S, Karpyak VM. Therapeutic Content of Mobile Phone Applications for Substance Use Disorders: An Umbrella Review Mayo Clinic Proceedings: Digital Health. 2024; 2(2):192-206.
  4. Ho MF, Zhang C, Moon I, Tuncturk M, Coombes BJ, Biernacka J, Skime M, Oesterle TS, Karpyak VM, Li H, Weinshilboum R. Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study. Transl Psychiatry. 2024 Mar 26; 14 (1):165
    View PubMed
  5. Ozel F, Di Criscio M, Lupu DI, Sarkisyan D, Hlady RA, Robertson KD, Bakalkin G, Liu Y, Biernacka JM, Karpyak VM, Ekstrom TJ, Ruegg J. DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment. Drug Alcohol Depend. 2024 Mar 1; 256:111116 Epub 2024 Feb 03
    View PubMed
  6. Ho MF, Zhang C, Moon I, Biernacka J, Coombes B, Ngo Q, Skillon C, Skime M, Oesterle T, Croarkin PE, Karpyak VM, Li H, Weinshilboum RM. Epigenetic regulation of GABA catabolism in iPSC-derived neurons: The molecular links between FGF21 and histone methylation. Mol Metab. 2023 Nov; 77:101798 Epub 2023 Sept 07
    View PubMed
  7. Karpyak VM, Coombes BJ, Geske JR, Pazdernik VM, Schneekloth T, Kolla BP, Oesterle T, Loukianova LL, Skime MK, Ho AMC, Ngo Q, Skillon C, Ho MF, Weinshilboum R, Biernacka JM. Corrigendum to "genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder" [Drug Alcohol Depend. 243 (2023) 109753]. Drug and Alcohol Dependence. 2023 Sep; 250:110888
  8. Karpyak VM, Coombes BJ, Geske JR, Pazdernik VM, Schneekloth T, Kolla BP, Oesterle T, Loukianova LL, Skime MK, Ho AM, Ngo Q, Skillon C, Ho MF, Weinshilboum R, Biernacka JM. Corrigendum to "Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder" [Drug Alcohol Depend. 243 (2023) 109753]. Drug Alcohol Depend. 2023 Sep 1; 250:110888 Epub 2023 July 11
    View PubMed
  9. Kolla BP, Winham SJ, Ho AM, Mansukhani MP, Loukianova LL, Pazdernik V, Karpyak VM. The Interaction Between Brain-Derived Neurotrophic Factor Levels and Alcohol Consumption, Sleep Disturbance and Sex-Hormones in Alcohol Use Disorders. Alcohol Alcohol. 2023 Mar 10; 58 (2):209-215
    View PubMed
  10. Ho AM, Pozsonyiova S, Waller TC, Song Y, Geske JR, Karpyak VM, Winham SJ. Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study. Drug Alcohol Depend. 2023 Mar 1; 244:109781 Epub 2023 Jan 18
    View PubMed
  11. Karpyak VM, Coombes BJ, Geske JR, Pazdernik VM, Schneekloth T, Kolla BP, Oesterle T, Loukianova LL, Skime MK, Ho AM, Ngo Q, Skillon C, Ho MF, Weinshilboum R, Biernacka JM. Genetic predisposition to major depressive disorder differentially impacts alcohol consumption and high-risk drinking situations in men and women with alcohol use disorder. Drug Alcohol Depend. 2023 Feb 1; 243:109753 Epub 2022 Dec 24
    View PubMed
  12. Oesterle TS, Karpyak VM, Coombes BJ, Athreya AP, Breitinger SA, Correa da Costa S, Dana Gerberi DJ. Systematic review: Wearable remote monitoring to detect nonalcohol/nonnicotine-related substance use disorder symptoms. Am J Addict. 2022 Nov; 31 (6):535-545 Epub 2022 Sept 05
    View PubMed
  13. Ho MF, Zhang C, Moon I, Zhu X, Coombes BJ, Biernacka J, Skime M, Oesterle TS, Karpyak VM, Schmidt K, Gliske K, Ngo Q, Skillon C, Seppala MD, Li H, Weinshilboum RM. Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder. Mol Psychiatry. 2022 Oct 27 [Epub ahead of print]
    View PubMed
  14. Ho MF, Zhang C, Moon I, Wei L, Coombes B, Biernacka J, Skime M, Choi DS, Frye M, Schmidt K, Gliske K, Braughton J, Ngo Q, Skillon C, Seppala M, Oesterle T, Karpyak V, Li H, Weinshilboum R. Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: Molecular links between the SNHG16 locus and catecholamine metabolism. Mol Metab. 2022 Sep; 63:101534 Epub 2022 June 22
    View PubMed
  15. Ho MF, Zhang C, Wei L, Zhang L, Moon I, Geske JR, Skime MK, Choi DS, Biernacka JM, Oesterle TS, Frye MA, Seppala MD, Karpyak VM, Li H, Weinshilboum RM. Genetic variants associated with acamprosate treatment response in alcohol use disorder patients: A multiple omics study. Br J Pharmacol. 2022 Jul; 179 (13):3330-3345 Epub 2022 Feb 08
    View PubMed
  16. Ho MF, Zhang C, Moon I, Coombes BJ, Biernacka J, Skime M, Choi DS, Croarkin PE, Frye MA, Ngo Q, Skillon C, Oesterle TS, Karpyak VM, Li H, Weinshilboum RM. Plasma TNFSF10 levels associated with acamprosate treatment response in patients with alcohol use disorder. Front Pharmacol. 2022; 13:986238 Epub 2022 Sept 01
    View PubMed
  17. Schneekloth TD, Arab JP, Simonetto DA, Petterson TM, Niazi SK, Hall-Flavin DK, Karpyak VM, Kolla BP, Roth JE, Kremers WK, Rosen CB. Factors Having an Impact on Relapse and Survival in Transplant Recipients With Alcohol-Induced Liver Disease. Mayo Clin Proc Innov Qual Outcomes. 2021 Dec; 5 (6):1153-1164 Epub 2021 Dec 08
    View PubMed
  18. Biernacka JM, Coombes BJ, Batzler A, Ho AM, Geske JR, Frank J, Hodgkinson C, Skime M, Colby C, Zillich L, Pozsonyiova S, Ho MF, Kiefer F, Rietschel M, Weinshilboum R, O'Malley SS, Mann K, Anton R, Goldman D, Karpyak VM. Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study. Neuropsychopharmacology. 2021 Nov; 46(12):2132-2139. Epub 2021 Jul 23.
    View PubMed
  19. Meng W, Sjoholm LK, Kononenko O, Tay N, Zhang D, Sarkisyan D, Geske JR, Ing A, Qiu W, Watanabe H, Almamoun R, Frieling H, Bleich S, Cui D, Biernacka JM, Mayfield RD, Dang Y, Karpyak VM, Schumann G, Bakalkin G, Ekstrom TJ, Ruegg J, Liu Y, IMAGEN Consortium. Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Mol Psychiatry. 2021 Aug; 26 (8):4367-4382 Epub 2019 Nov 19
    View PubMed
  20. Ho MF, Zhang C, Zhang L, Wei L, Zhou Y, Moon I, Geske JR, Choi DS, Biernacka J, Frye M, Wen Z, Karpyak VM, Li H, Weinshilboum R. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Mol Psychiatry. 2021 Jul; 26 (7):3122-3133 Epub 2020 Aug 04
    View PubMed
  21. Nosova O, Bazov I, Karpyak V, Hallberg M, Bakalkin G. Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain. Molecules. 2021 Jun 7; 26 (11) Epub 2021 June 07
    View PubMed
  22. Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hubel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppa VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodriguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramis G, Esko T, Estivill X, Farmer A, Favaro A, Fernandez-Aranda F, Fichter MM, Fischer K, Focker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jimenez-Murcia S, Julia A, Kalsi G, Kaminska D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Swiatkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegard A, Lichtenstein P, Norring C, Landen M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, et al, Choi DS, Frye MA, Brown SA, Karpyak VM, Zhao H. Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addict Biol. 2021 Jan; 26 (1):e12880 Epub 2020 Feb 16
    View PubMed
  23. Fairbanks J, Umbreit A, Prakash Kolla B, Kolla BP, Karpyak VM, Schneekloth TD, Loukianova LL, Sinha S. Evidence-Based Pharmacotherapies for Alcohol Use Disorder: Clinical Pearls. Mayo Clin Proc. 2020 Sep; 95 (9):1964-1977 Epub 2020 May 20
    View PubMed
  24. Starski P, Hong SI, Peyton L, Oliveros A, Wininger K, Hutchison C, Kang S, Karpyak V, Choi DS. Ethanol induces maladaptive impulse control and decreased seeking behaviors in mice. Addict Biol. 2020 May; 25 (3):e12754 Epub 2019 Apr 22
    View PubMed
  25. Gandhi KD, Mansukhani MP, Karpyak VM, Schneekloth TD, Wang Z, Kolla BP. The Impact of Varenicline on Alcohol Consumption in Subjects With Alcohol Use Disorders: Systematic Review and Meta-Analyses. J Clin Psychiatry. 2020 Feb 25; 81 (2)
    View PubMed
  26. Peeraphatdit TB, Kamath PS, Karpyak VM, Davis B, Desai V, Liangpunsakul S, Sanyal A, Chalasani N, Shah VH, Simonetto DA. Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2020 Feb; 18 (2):477-485.e5 Epub 2019 Apr 28
    View PubMed
  27. Kolla BP, Mansukhani MP, Biernacka J, Chakravorty S, Karpyak VM. Sleep disturbances in early alcohol recovery: Prevalence and associations with clinical characteristics and severity of alcohol consumption. Drug Alcohol Depend. 2020 Jan 1; 206:107655 Epub 2019 Nov 05
    View PubMed
  28. Reyes MM, Schneekloth TD, Hitschfeld MJ, Karpyak VM. Impact of Sex and ADHD Status on Psychiatric Comorbidity in Treatment-Seeking Alcoholics. J Atten Disord. 2019 Oct; 23 (12):1505-1513 Epub 2018 Nov 04
    View PubMed
  29. Reyes MM, Schneekloth TD, Hitschfeld MJ, Geske JR, Atkinson DL, Karpyak VM. The Clinical Utility of ASRS-v1.1 for Identifying ADHD in Alcoholics Using PRISM as the Reference Standard. J Atten Disord. 2019 Aug; 23 (10):1119-1125 Epub 2016 May 02
    View PubMed
  30. Stark AL, Hickson LJ, Larrabee BR, Thusius NJ, Karpyak VM, Hall-Flavin DK, Schneekloth TD. Cannabis abuse and dependence in kidney transplant candidates. J Psychosom Res. 2019 Jun; 121:68-73 Epub 2019 Apr 12
    View PubMed
  31. Ho AM, Geske JR, Bakalkin G, Winham SJ, Karpyak VM. Correlations between sex-related hormones, alcohol dependence and alcohol craving. Drug Alcohol Depend. 2019 Apr 1; 197:183-190 Epub 2019 Feb 27
    View PubMed
  32. Stohs ME, Schneekloth TD, Geske JR, Biernacka JM, Karpyak VM. Alcohol Craving Predicts Relapse After Residential Addiction Treatment. Alcohol Alcohol. 2019 Mar 1; 54 (2):167-172
    View PubMed
  33. Karpyak VM, Geske JR, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Seppala M, Dawson G, Frye MA, Choi DS, Biernacka JM. Sex-specific association of depressive disorder and transient emotional states with alcohol consumption in male and female alcoholics. Drug Alcohol Depend. 2019 Mar 1; 196:31-39 Epub 2019 Jan 11
    View PubMed
  34. Erol A, Ho AM, Winham SJ, Karpyak VM. Sex hormones in alcohol consumption: a systematic review of evidence. Addict Biol. 2019 Mar; 24 (2):157-169 Epub 2017 Dec 27
    View PubMed
  35. Romanowicz M, Vande Voort JL, Shekunov J, Oesterle TS, Thusius NJ, Rummans TA, Croarkin PE, Karpyak VM, Lynch BA, Schak KM. The effects of parental opioid use on the parent-child relationship and children's developmental and behavioral outcomes: a systematic review of published reports. Child Adolesc Psychiatry Ment Health. 2019; 13:5 Epub 2019 Jan 12
    View PubMed
  36. Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gabel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Mannisto S, Muller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Raikkonen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nothen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A, 23andMe Research Team. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 Dec; 21 (12):1656-1669 Epub 2018 Nov 26
    View PubMed
  37. Kolla BP, Schneekloth TD, Biernacka J, Shah V, Lazaridis KN, Geske J, Karpyak V. PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers. Alcohol Alcohol. 2018 Jul 1; 53 (4):357-360
    View PubMed
  38. Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Karpyak VM, Yakovleva T, Bakalkin G. Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics. Transl Psychiatry. 2018 Jun 20; 8 (1):122 Epub 2018 June 20
    View PubMed
  39. Hinton DJ, Vazquez MS, Geske JR, Hitschfeld MJ, Ho AMC, Karpyak VM, Biernacka JM, Choi DS. Metabolomics biomarkers to predict acamprosate treatment response in alcohol-dependent subjects. Sci Rep. 2017 May 31; 7 (1):2496
    View PubMed
  40. Frye MA, Hinton DJ, Karpyak VM, Biernacka JM, Gunderson LJ, Feeder SE, Choi DS, Port JD. Anterior Cingulate Glutamate Is Reduced by Acamprosate Treatment in Patients With Alcohol Dependence. J Clin Psychopharmacol. 2016 Dec; 36 (6):669-674
    View PubMed
  41. Frye MA, Hinton DJ, Karpyak VM, Biernacka JM, Gunderson LJ, Geske J, Feeder SE, Choi DS, Port JD. Elevated Glutamate Levels in the Left Dorsolateral Prefrontal Cortex Are Associated with Higher Cravings for Alcohol. Alcohol Clin Exp Res. 2016 Aug; 40 (8):1609-16 Epub 2016 July 20
    View PubMed
  42. Karpyak VM, Biernacka JM, Geske JR, Abulseoud OA, Brunner MD, Chauhan M, Hall-Flavin DK, Lewis KA, Loukianova LL, Melnyk GJ, Onsrud DA, Proctor BD, Schneekloth TD, Skime MK, Wittkopp JE, Frye MA, Mrazek DA. Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states. Addiction. 2016 Aug; 111 (8):1366-75 Epub 2016 May 05
    View PubMed
  43. Ho AM, Qiu Y, Jia YF, Aguiar FS, Hinton DJ, Karpyak VM, Weinshilboum RM, Choi DS. Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice. Alcohol Clin Exp Res. 2016 Jul; 40 (7):1531-9 Epub 2016 May 17
    View PubMed
  44. Erol A, Karpyak VM. Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations. Drug Alcohol Depend. 2015 Nov 1; 156:1-13 Epub 2015 Sept 05
    View PubMed
  45. Winham SJ, Preuss UW, Geske JR, Zill P, Heit JA, Bakalkin G, Biernacka JM, Karpyak VM. Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent. Sci Rep. 2015 Oct 27; 5:15670
    View PubMed
  46. Nam HW, Karpyak VM, Hinton DJ, Geske JR, Ho AM, Prieto ML, Biernacka JM, Frye MA, Weinshilboum RM, Choi DS. Elevated baseline serum glutamate as a pharmacometabolomic biomarker for acamprosate treatment outcome in alcohol-dependent subjects. Transl Psychiatry. 2015 Aug 18; 5:e621
    View PubMed
  47. Kolla BP, Schneekloth T, Mansukhani MP, Biernacka JM, Hall-Flavin D, Karpyak V, Geske J, Frye MA. The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study. Am J Addict. 2015 Jun; 24: (4)362-7.
    View PubMed
  48. Hitschfeld MJ, Schneekloth TD, Ebbert JO, Hall-Flavin DK, Karpyak VM, Abulseoud OA, Patten CA, Geske JR, Frye MA. Female smokers have the highest alcohol craving in a residential alcoholism treatment cohort. Drug Alcohol Depend. 2015 May 1; 150:179-82 Epub 2015 Feb 25
    View PubMed
  49. Abulseoud OA, Gawad NA, Mohamed K, Vadnie C, Camsari UM, Karpyak V, Frye MA, Choi DS. Sex differences in mania phenotype and ethanol consumption in the lateral hypothalamic kindled rat model. Transl Psychiatry. 2015 Mar 24; 5 (3):e534
    View PubMed
  50. Cuellar-Barboza AB, Frye MA, Grothe K, Prieto ML, Schneekloth TD, Loukianova LL, Hall-Flavin DK, Clark MM, Karpyak VM, Miller JD, Abulseoud OA. Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery. J Psychosom Res. 2015 Mar; 78 (3):199-204 Epub 2014 Sept 07
    View PubMed
  51. Moyer AM, Walker DL, Avula R, Lapid MI, Kung S, Bryant SC, Edwards KK, Black JL, Karpyak VM, Shinozaki G, Jowsey-Gregoire SG, Ehlers SL, Romanowicz M, Litzow MR, Hogan WJ, Rundell JR, Hooten WM, Baudhuin LM. Relationship of genetic variation in the serotonin transporter gene (SLC6A4) and congenital and acquired cardiovascular diseases. Genet Test Mol Biomarkers. 2015 Mar; 19(3):115-23. Epub 2015 Feb 11.
    View PubMed
  52. Watanabe H, Fitting S, Hussain MZ, Kononenko O, Iatsyshyna A, Yoshitake T, Kehr J, Alkass K, Druid H, Wadensten H, Andren PE, Nylander I, Wedell DH, Krishtal O, Hauser KF, Nyberg F, Karpyak VM, Yakovleva T, Bakalkin G. Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain. Cereb Cortex. 2015 Jan; 25 (1):97-108 Epub 2013 Aug 19
    View PubMed
  53. Sarkisyan D, Hussain MZ, Watanabe H, Kononenko O, Bazov I, Zhou X, Yamskova O, Krishtal O, Karpyak VM, Yakovleva T, Bakalkin G. Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. Front Cell Neurosci. 2015; 9:187 Epub 2015 May 12
    View PubMed
  54. Karpyak VM, Biernacka JM, Geske JR, Jenkins GD, Cunningham JM, Ruegg J, Kononenko O, Leontovich AA, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Frank J, Nothen MM, Rietschel M, Kiefer F, Mann KF, Weinshilboum RM, Frye MA, Choi DS. Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate. Transl Psychiatry. 2014 Oct 7; 4:e462 Epub 2014 Oct 07
    View PubMed
  55. Mrazek DA, Biernacka JM, McAlpine DE, Benitez J, Karpyak VM, Williams MD, Hall-Flavin DK, Netzel PJ, Passov V, Rohland BM, Shinozaki G, Hoberg AA, Snyder KA, Drews MS, Skime MK, Sagen JA, Schaid DJ, Weinshilboum R, Katzelnick DJ. Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study. J Clin Psychopharmacol. 2014 Jun; 34 (3):313-7
    View PubMed
  56. Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 2014 Mar; 19 (2):312-5 Epub 2012 Aug 02
    View PubMed
  57. Karpyak VM, Romanowicz M, Schmidt JE, Lewis KA, Bostwick JM. Characteristics of heart rate variability in alcohol-dependent subjects and nondependent chronic alcohol users. Alcohol Clin Exp Res. 2014 Jan; 38 (1):9-26 Epub 2013 Oct 11
    View PubMed
  58. Kolla BP, Schneekloth T, Biernacka J, Mansukhani M, Geske J, Karpyak V, Hall-Flavin D, Louikianova L, Frye MA. The course of sleep disturbances in early alcohol recovery: an observational cohort study. Am J Addict. 2014 Jan-Feb; 23: (1)21-6.
    View PubMed
  59. Abulseoud OA, Karpyak VM, Schneekloth T, Hall-Flavin DK, Loukianova LL, Geske JR, Biernacka JM, Mrazek DA, Frye MA. A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence. Am J Addict. 2013 Sep-Oct; 22 (5):437-42 Epub 2013 May 30
    View PubMed
  60. Karpyak VM, Winham SJ, Preuss UW, Zill P, Cunningham JM, Walker DL, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Bazov I, Heit JA, Bakalkin G, Mrazek DA, Biernacka JM. Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. Int J Neuropsychopharmacol. 2013 Jun; 16 (5):975-85 Epub 2012 Oct 29
    View PubMed
  61. Biernacka JM, Geske J, Jenkins GD, Colby C, Rider DN, Karpyak VM, Choi DS, Fridley BL. Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence. Int J Neuropsychopharmacol. 2013 Mar; 16 (2):271-8 Epub 2012 May 02
    View PubMed
  62. Preuss UW, Winham SJ, Biernacka JM, Geske JR, Bakalkin G, Koller G, Zill P, Soyka M, Karpyak VM. PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort. PLoS One. 2013; 8(11):e78688. Epub 2013 Nov 06.
    View PubMed
  63. Biernacka JM, Geske JR, Schneekloth TD, Frye MA, Cunningham JM, Choi DS, Tapp CL, Lewis BR, Drews MS, L Pietrzak T, Colby CL, Hall-Flavin DK, Loukianova LL, Heit JA, Mrazek DA, Karpyak VM. Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. PLoS One. 2013; 8 (3):e58798 Epub 2013 Mar 13
    View PubMed
  64. Schneekloth TD, Biernacka JM, Hall-Flavin DK, Karpyak VM, Frye MA, Loukianova LL, Stevens SR, Drews MS, Geske JR, Mrazek DA. Alcohol craving as a predictor of relapse. Am J Addict. 2012 Nov; 21 Suppl 1:S20-6.
    View PubMed
  65. Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM. Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addict Biol. 2012 Jul; 17 (4):798-806 Epub 2011 July 18
    View PubMed
  66. Klee EW, Schneider H, Clark KJ, Cousin MA, Ebbert JO, Hooten WM, Karpyak VM, Warner DO, Ekker SC. Zebrafish: a model for the study of addiction genetics. Hum Genet. 2012 Jun; 131 (6):977-1008 Epub 2011 Dec 30
    View PubMed
  67. Kolla BP, Schneekloth TD, Biernacka JM, Frye MA, Mansukhani MP, Hall-Flavin DK, Karpyak VM, Loukianova LL, Lesnick TG, Mrazek D. Trazodone and alcohol relapse: a retrospective study following residential treatment. Am J Addict. 2011 Nov-Dec; 20 (6):525-9 Epub 2011 Sept 29
    View PubMed
  68. Romanowicz M, Schmidt JE, Bostwick JM, Mrazek DA, Karpyak VM. Changes in heart rate variability associated with acute alcohol consumption: current knowledge and implications for practice and research. Alcohol Clin Exp Res. 2011 Jun; 35(6):1092-105. Epub 2011 Feb 17.
    View PubMed
  69. Kim JH, Karpyak VM, Biernacka JM, Nam HW, Lee MR, Preuss UW, Zill P, Yoon G, Colby C, Mrazek DA, Choi DS. Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS One. 2011 Jan 24; 6 (1):e16331
    View PubMed
  70. Hall-Flavin DK, Schneekloth TD, Loukianova LL, Karpyak VM, Lesnick TG, Biernacka JM, Mrazek DA, Frye MA. Utilization of residential alcoholism treatment in bipolar disorder. Am J Addict. 2011 Jan-Feb; 20 (1):40-4 Epub 2010 Nov 12
    View PubMed
  71. Schneekloth TD, Biernacka JM, Hall-Flavin DK, Karpyak VM, Frye MA, Loukianova LL, Stevens SR, Drews MS, Geske JR, Mrazek DA. Alcohol Craving as a Predictor of Relapse. Am J Addict. 2011(in Press).
  72. Boykoff N, Schneekloth TD, Hall-Flavin D, Loukianova L, Karpyak VM, Stevens SR, Biernacka JM, Mrazek DA, Frye MA. Gender differences in the relationship between depressive symptoms and cravings in alcoholism. Am J Addict. 2010 Jul-Aug; 19 (4):352-6
    View PubMed
  73. Karpyak VM, Biernacka JM, Weg MW, Stevens SR, Cunningham JM, Mrazek DA, Black JL. Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens. Addict Biol. 2010 Jan; 15(1):23-34.
    View PubMed
  74. Karpyak VM, Kim JH, Biernacka JM, Wieben ED, Mrazek DA, Black JL, Choi DS. Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry. Alcohol Clin Exp Res. 2009 Apr; 33 (4):712-21 Epub 2009 Jan 21
    View PubMed
  75. Dodd ML, Dolenc TJ, Karpyak VM, Rasmussen KG. QTc dispersion in patients referred for electroconvulsive therapy. J ECT. 2008 Jun; 24(2):131-3.
    View PubMed
  76. Karpyak VM, Hall-Flavin DK, Mrazek DA. Can genetics predict risk for alcohol dependence? Current Psychiatry. 2008; 7(3):57-73.
  77. Karpyak VM, Rasmussen KG, Hammill SC, Mrazek DA. Changes in heart rate variability in response to treatment with electroconvulsive therapy. J ECT. 2004 Jun; 20 (2):81-8
    View PubMed
  78. Rasmussen KG, Karpyak VM, Hammill SC. Lack of effect of ECT on Holter monitor recordings before and after treatment. J ECT. 2004 Mar; 20 (1):45-7
    View PubMed
  79. Karpyak VM. Paroxysmal disorders during the clinical course of alcoholism (review of the literature). (In Russian). Zhurnal Nevropatologii i Psykhiatrii Imeni. 1989; 89:132-40.