Overview

The Tendon and Soft Tissue Biology Laboratory of Peter C. Amadio, M.D., researches injuries to tendons and soft tissues, including carpal tunnel syndrome, rotator cuff injuries, and face and hand transplant needs.

Flexor tendon injury and repair poses a surgical challenge because of the high complication rate, including adhesion formation, gapping and rupture, which typically require a second surgery to restore finger function.

Research goals and topics

Our research goals focus on several important topics related to improving the outcomes of flexor tendon repair.

These include:

• Development of a tendon lubricant.
• 3D atlas of the hand.
• Senescence in carpal tunnel syndrome.
• Optimal postoperative rehabilitation.
• Appropriate surgical repair and reconstruction techniques.
• Role of growth factor on tendon healing and adhesion formation.

Research in our lab encompasses a wide range of disciplines and technologies. These include orthopedics, biomechanics, biochemistry, dynamic ultrasound, and molecular and cell biology.

A main goal of Dr. Amadio's lab is to improve the results of tendon repair by applying tissue engineering approaches to two interrelated concerns:

• The effect of loading on wound healing and soft tissue material properties (Wolff's law of soft tissue).
• The effect of tendon repair and lubrication on tendon gliding.
• Read more about our research projects.

About Dr. Amadio

In addition to directing the Tendon and Soft Tissue Biology Lab, Dr. Amadio is a hand and orthopedic surgeon. He also is a professor of orthopedics and a professor of biomedical engineering at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. Dr. Amadio has the distinction of being the Lloyd A. and Barbara A. Amundson Professor of Orthopedics. Dr. Amadio is an active member of the Division of Hand Surgery in the Department of Orthopedic Surgery. His clinical interests include congenital hand diseases, upper extremity tumors and distal upper extremity tendon injuries.