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Yifei K. Yang, Ph.D., is a laboratory medicine researcher at Mayo Clinic whose research aim is to translate biomarker discoveries into clinically validated in vitro diagnostic tests. To achieve this goal, Dr. Yang's work focuses on identifying diagnostic biomarkers using new-generation mass spectrometers by exploring their post-translational modification profiles in autoimmune and neoplastic conditions. Dr. Yang also studies ways to improve the efficiency and throughput of mass spectrometry-based clinical assays by implementing and evaluating process automations in both preanalytical and data analysis phases.
Diagnostic assays play a pivotal role in medical evaluation and management of patients. Dr. Yang's research aspires to improve the diagnostic capacity of existing cancer and autoimmune biomarkers by profiling their post-translational modifications and correlating those with diseases and pathological conditions. Such information beyond genomic and proteomic profiles can offer diagnostic tests to patients with higher precision in an individualized manner.
Dr. Yang also aims to improve patient access to routine drug monitoring assays by increasing the efficiency and throughput of mass spectrometry-based toxicology assays. By combining instrumentation automation and algorithm-based result interpretation, Dr. Yang aims to reduce the economic burden of toxicology testing associated with long-term medication-assisted treatment for substance use disorders.
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