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Brian G. Weinshenker, M.D., has several research interests related to inflammatory demyelinating diseases of the central nervous system (CNS).
Fulminant demyelination and neuromyelitis optica (NMO). Dr. Weinshenker investigates the classification and treatment of fulminant demyelinating diseases of the CNS and co-developed diagnostic criteria and characterized the natural history of neuromyelitis optica (Devic's disease), including the recent International Panel for NMO Diagnosis, the recommendations of which were published in 2015 and serve as the standard for diagnosis of this condition.
Dr. Weinshenker was a member of the team whose research led to the discovery of NMO-IgG, a highly specific and moderately sensitive new antibody biomarker for neuromyelitis optica and other restricted types of inflammatory demyelination — including longitudinally extensive transverse myelitis and recurrent optic neuritis. He demonstrated that aquaporin-4 is highly expressed in the optic nerve and spinal cord relative to other regions of the central nervous system that, in part, explains the unique topography of lesions of neuromyelitis optica.
The research conducted by Dr. Weinshenker will lead to improved diagnostics and therapies for patients with demyelinating diseases.
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