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Peripheral nerve injury (PNI) results in debilitating loss of limb function and oftentimes disabling pain. In addition to personal hardship, PNI places considerable demands on rehabilitation resources and creates an enormous socioeconomic burden.
Even with modern surgical procedures and advanced instrumentation, nerve regeneration and functional recovery following nerve repair is far from satisfactory. One of the major challenges is the narrow window of opportunity beyond which the capacity of a nerve to regrow declines and the extent of functional recovery marginalizes.
Huan Wang, M.D., Ph.D. and her colleagues focus on developing strategies to expand the time window of opportunity and improve functional outcomes after nerve reconstruction.
Dr. Wang’s research aims to determine the extent of detrimental changes following nerve injury and the prognostic factors that help physicians more accurately predict an individual patient's chances for success with different surgical interventions. This will also shed light on identifying key factors that hinder nerve regeneration and lead to interventions to overcome these obstacles.
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