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The primary research interest of Marin Veldic, M.D., is in molecular epigenetics and development of novel treatment protocols for bipolar disorder.
Epigenetics is the study of changes in gene activity that are not caused by variations in the DNA sequence. Epigenetic changes can be inherited and are susceptible to a wide range of environmental influences.
Dr. Veldic is currently studying epigenetic regulation of the neurotransmitter glutamate and related genes in bipolar disorder. He is also exploring the impact of epigenetic mechanisms on chronic pain conditions in children and adolescents. Dr. Veldic's ultimate goal is to develop more-effective individualized treatment protocols for mood disorders and other conditions that are presumably under strong epigenetic influence.
Identifying clinical phenotypes and advancing the understanding of epigenomic and pharmacogenomic profiles lays a foundation for individualized treatment protocols for patients with bipolar disorder and other major psychiatric disorders.
From a practical perspective, the hope is that future routine psychiatric practices will involve administration of simple blood, saliva or urine tests to confirm the diagnosis and guide treatment selection, just as in other branches of medicine.
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