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Kathryn (Katie) M. Van Abel, M.D., an otolaryngologist at Mayo Clinic, studies a range of diseases, primarily cancer, that affect the head and neck. Dr. Van Abel's main research focus is the study of cancer of the throat, tonsil and base of tongue (oropharyngeal squamous cell carcinoma), with a specific emphasis on human papillomavirus (HPV)-driven disease.
Dr. Van Abel conducts prospective randomized interventional de-escalation trials and maintains an extensive registry that offers insight into patient and oncologic outcomes by collaborating with teams across Mayo Clinic to investigate DNA methylation profiles. She also studies biomarkers, including circulating tumor DNA and oral microbiome signatures. She investigates the T cell repertoire within primary and nodal tissue using imaging mass cytometry and assesses both patient and partner risk of anogenital HPV disease. Dr. Van Abel also investigates novel aggressive dose de-escalation for patients with lower risk disease and escalation protocols for patients with higher risk disease to individualize treatment strategies, with the goal of maximizing the chance of cure while minimizing the side effects of treatment.
Working with a multidisciplinary team of colleagues also passionate about treating patients who develop head and neck cancer, Dr. Van Abel aims to answer questions that both advance the science and immediately improve the lives of patients. Dr. Van Abel is dedicated to an individualized approach that provides the right amount of treatment to provide a cure with the least amount of side effects.
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