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The research interests of Ramandeep S. Takhter, Ph.D., focus on cardiovascular protection and regeneration, including creating a cell-free platform to deliver genes of interest for targeted and temporally restricted genes therapy.
Cardiomyocytes are specialized cardiac muscle cells responsible for maintaining normal beating of the heart and are unable to naturally regenerate, making the heart incapable of natural regeneration. Dr. Takhter envisions this cardioprotective and regenerative approach could revolutionize care for patients with heart attacks, as it could lessen or even stop the progression toward fatal heart disease.
Dr. Takhter is also researching the generation of functional cardiomyocytes from mesenchymal stem cells using a combination of genetic approaches and chemical alterations that may be utilized in cell therapy to regenerate heart tissue caused by lack of blood flow to the heart during a heart attack.
Heart disease is the No. 1 cause of death in the United States, and cardiovascular diseases claim more lives than all forms of cancer combined. Dr. Takhter and his colleagues are dedicated to developing beneficial cell-free or cell-based cardiovascular therapeutics that help patients with heart disease and are also affordable.
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