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The research of Marissa J. Schafer, Ph.D., focuses on cellular and molecular mechanisms that contribute to age-related brain dysfunction, with the goal of developing strategies to prevent, slow or reverse cognitive decline. Cellular senescence and inflammation are interconnected causes and consequences of tissue aging. Dr. Schafer and her research team synergistically investigate the brain-specific and peripheral impact of senescent cells and inflammation on brain aging and cognitive health.
Researchers in Dr. Schafer's lab implement a multidisciplinary approach that spans the basic-to-translational continuum. They leverage state-of-the-art cellular, molecular and behavioral methods in mouse models of aging, coupled with clinical data and biomarker analyses, to discover mechanisms of dysfunction and develop therapeutics to combat age-related cognitive dysfunction.
Aging is a primary risk factor for multiple chronic conditions, including cognitive decline and dementia. Dr. Schafer's lab seeks to understand fundamental aging mechanisms and their influence on local and systemic tissue health and function. Their goal is to identify therapeutic approaches that may prevent or reduce late-life cognitive dysfunction, which has broad societal impact.
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