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The research of Mimi C. Sammarco, Ph.D., focuses on limb regeneration after traumatic injury. Although complete regeneration of a limb isn't possible, regenerative approaches that extend limbs or improve the integration of prosthetics can vastly improve quality of life for people with limb loss or limb differences.
Understanding the mechanisms that drive tissue replacement and patterning and delineating the timeline that drives this regenerative event are key steps in moving toward translational and clinical approaches to replace bone and soft tissue.
While whole limbs don't regenerate, amputation of the digit tip provides an ideal regenerating model for the limb and results in high-fidelity replacement of bone and soft tissue. Limb amputation and digit amputation closer to the palm result in callus formation, fibrotic scarring and failure to regenerate. Dr. Sammarco and her team in the Limb and Musculoskeletal Regenerative Research Laboratory use a mouse model to understand the complex interactions of a multitissue regenerative system and identify the mechanisms that drive cell differentiation and patterning during the regenerative process.
Dr. Sammarco's research uses digit tip amputation as a model to explore how to restore bone and tissue after larger amputation injuries, such as the loss of a leg. Limb regeneration is limited in humans, and injury usually results in thickening and scarring, a process called fibrotic response. Understanding the mechanisms behind regenerative and fibrotic healing in the limb is important to promoting translational studies and better treatments. Dr. Sammarco hopes to identify treatments using genetics and medicine to help regeneration and healing.
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