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Melissa E. Murray, Ph.D., and her colleagues in Mayo Clinic's Translational Neuropathology Lab, use a multidisciplinary approach that integrates neuropathology, neuroimaging and genetics to investigate neurocognitive disorders (Alzheimer's disease), parkinsonian disorders (dementia with Lewy bodies) and motor neuron disorders (Lou Gehrig's disease). Dr. Murray is specifically interested in the effect of brain aging overlaid with a neurodegenerative disorder. The lab has revealed striking differences regarding vulnerability or resilience in affected individuals, especially in the setting of Alzheimer's disease (AD).
Dr. Murray's research seeks to improve diagnostic clinical accuracy through work with neurologists and radiologists. By carefully observing changes in the brain related to specific diseases, stereotypical patterns are evident. There are, however, groups of individuals whose disease pattern is far different, which often leads to an inaccurate diagnosis.
Overall, Dr. Murray's goal is to identify predictors of atypical patterns to assist neurologists with clinical interpretation and radiologists with neuroimaging interpretation. Dr. Murray is currently undertaking a genetic study to identify gene changes that lead to heightened susceptibility or resilience within the brains of patients in order to identify biological mechanisms that contribute to atypical disease patterns.
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