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John B. Kisiel, M.D., focuses his research primarily on the discovery and translation of biomarkers for the early detection of cancer. Collaborating industrywide, Dr. Kisiel's team of multidisciplinary, translational and academic investigators seeks to leverage molecular markers for noninvasive cancer screening and surveillance.
Stool DNA testing has been used to screen for colorectal cancer in over 4 million people. The DNA methylation marker technology used in this test also shows promise for detecting cancers throughout the body when sampled from blood or through other minimally invasive means. Dr. Kisiel and his colleagues are working to develop this technology to noninvasively screen for cancers that are difficult to detect with currently available tools. With this effort, they hope to transform the practice of cancer screening by enabling highly lethal cancers to be found and treated at a curable stage.
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